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    Serpini2 serine (or cysteine) peptidase inhibitor, clade I, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 67931, updated on 9-Dec-2024

    Summary

    Official Symbol
    Serpini2provided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade I, member 2provided by MGI
    Primary source
    MGI:MGI:1915181
    See related
    Ensembl:ENSMUSG00000034139 AllianceGenome:MGI:1915181
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spi14
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Located in collagen-containing extracellular matrix. Used to study Shwachman-Diamond syndrome. Orthologous to human SERPINI2 (serpin family I member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See Serpini2 in Genome Data Viewer
    Location:
    3 E3; 3 33.74 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (75149664..75177385, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (75242357..75270078, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene zinc finger, B-box domain containing Neighboring gene predicted gene, 40071 Neighboring gene STARR-seq mESC enhancer starr_07968 Neighboring gene WD repeat domain 49 Neighboring gene predicted gene, 17836 Neighboring gene programmed cell death 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Transgenic (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    serpin I2
    Names
    pancreas-specific serpin
    serine protease inhibitor 14

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026460.3NP_080736.2  serpin I2 precursor

      See identical proteins and their annotated locations for NP_080736.2

      Status: VALIDATED

      Source sequence(s)
      AC147152, AK007510, AK008931
      Consensus CDS
      CCDS17413.1
      UniProtKB/Swiss-Prot
      Q9D8Z3, Q9D955, Q9JK88
      UniProtKB/TrEMBL
      Q4G0D3
      Related
      ENSMUSP00000046943.5, ENSMUST00000039047.5
      Conserved Domains (1) summary
      cd02048
      Location:23405
      neuroserpin; Neuroserpin is a inhibitory member of the SERine Proteinase INhibitor (serpin) family that reacts preferentially with tissue-type plasminogen activator (tPA). It is located in neurons in regions of the brain where tPA is also found, suggesting that ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      75149664..75177385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)