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    Tax1bp1 Tax1 (human T cell leukemia virus type I) binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 52440, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tax1bp1provided by MGI
    Official Full Name
    Tax1 (human T cell leukemia virus type I) binding protein 1provided by MGI
    Primary source
    MGI:MGI:1289308
    See related
    Ensembl:ENSMUSG00000004535 AllianceGenome:MGI:1289308
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    T6bp; TXBP151; D6Ertd404e; D6Ertd772e; 1200003J11Rik; 1700069J21Rik
    Summary
    Enables kinase binding activity. Involved in negative regulation of NF-kappaB transcription factor activity. Predicted to be located in autophagosome; cytoplasmic vesicle; and phagophore assembly site. Predicted to be active in mitochondrion. Is expressed in central nervous system; genital tubercle; limb mesenchyme; and retina nuclear layer. Orthologous to human TAX1BP1 (Tax1 binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 37.5), testis adult (RPKM 35.3) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tax1bp1 in Genome Data Viewer
    Location:
    6 B3; 6 25.7 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (52690677..52743765)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (52713692..52766780)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene 3-hydroxyisobutyrate dehydrogenase Neighboring gene STARR-positive B cell enhancer ABC_E536 Neighboring gene predicted gene, 24355 Neighboring gene STARR-positive B cell enhancer ABC_E8104 Neighboring gene 60S ribosomal protein L24 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:52767269-52767470 Neighboring gene JAZF zinc finger 1 Neighboring gene predicted gene, 52904 Neighboring gene STARR-seq mESC enhancer starr_15910 Neighboring gene STARR-seq mESC enhancer starr_15912 Neighboring gene predicted gene, 52903

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in autophagosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in phagophore assembly site IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tax1-binding protein 1 homolog
    Names
    TRAF6-binding protein homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355595.1NP_001342524.1  tax1-binding protein 1 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC099741, AC117212, BP754065
      Conserved Domains (1) summary
      cl25732
      Location:17398
      SMC_N; RecF/RecN/SMC N terminal domain
    2. NM_001355596.1NP_001342525.1  tax1-binding protein 1 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC099741, AC117212, BP754065
      Consensus CDS
      CCDS39490.1
      UniProtKB/Swiss-Prot
      Q3UKC1, Q91YT6, Q9CVF0, Q9DC45
      Conserved Domains (1) summary
      cl25732
      Location:17460
      SMC_N; RecF/RecN/SMC N terminal domain
    3. NM_025816.3NP_080092.2  tax1-binding protein 1 homolog isoform 1

      See identical proteins and their annotated locations for NP_080092.2

      Status: VALIDATED

      Source sequence(s)
      AC099741, AK146076, BP754065
      Consensus CDS
      CCDS39490.1
      UniProtKB/Swiss-Prot
      Q3UKC1, Q91YT6, Q9CVF0, Q9DC45
      Related
      ENSMUSP00000079548.5, ENSMUST00000080723.11
      Conserved Domains (1) summary
      cl25732
      Location:17460
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      52690677..52743765
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506370.5XP_006506433.1  tax1-binding protein 1 homolog isoform X1

      Conserved Domains (4) summary
      COG4372
      Location:338645
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      pfam07888
      Location:125408
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam17751
      Location:17120
      SKICH; SKICH domain
      pfam18112
      Location:704730
      Zn-C2H2_12; Autophagy receptor zinc finger-C2H2 domain