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    Gins2 GINS complex subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 272551, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gins2provided by MGI
    Official Full Name
    GINS complex subunit 2provided by MGI
    Primary source
    MGI:MGI:1921019
    See related
    Ensembl:ENSMUSG00000031821 AllianceGenome:MGI:1921019
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pfs2; Psf2; 2210013I18Rik; 4833427B12Rik
    Summary
    Predicted to be involved in DNA unwinding involved in DNA replication and double-strand break repair via break-induced replication. Predicted to be located in nucleus. Predicted to be part of CMG complex and GINS complex. Is expressed in cerebral cortex subventricular zone; cortical plate; and heart. Orthologous to human GINS2 (GINS complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 32.6), liver E14.5 (RPKM 25.4) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gins2 in Genome Data Viewer
    Location:
    8 E1; 8 69.86 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (121308005..121315814, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (120581266..120589075, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene genetic suppressor element 1, coiled-coil protein Neighboring gene RIKEN cDNA 1700016A09 gene Neighboring gene STARR-positive B cell enhancer ABC_E9746 Neighboring gene STARR-positive B cell enhancer ABC_E362 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:123063389-123063498 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:123067513-123067836 Neighboring gene microRNA 7687 Neighboring gene STARR-positive B cell enhancer ABC_E246 Neighboring gene RIKEN cDNA 1190005I06 gene Neighboring gene predicted gene 10614 Neighboring gene STARR-seq mESC enhancer starr_22909 Neighboring gene predicted gene, 27021 Neighboring gene predicted gene, 33075

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GINS complex subunit 2 (GINS2) plays a protective role in alcohol-induced brain injury. Liu C, et al. Artif Cells Nanomed Biotechnol, 2019 Dec. PMID 30513217
    2. A key role for the GINS complex at DNA replication forks. Labib K, et al. Trends Cell Biol, 2007 Jun. PMID 17467990
    3. CUL2(LRR1) , TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle. Villa F, et al. EMBO Rep, 2021 Mar 3. PMID 33590678, Free PMC Article
    4. Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis. Kang YH, et al. Proc Natl Acad Sci U S A, 2012 Apr 17. PMID 22474384, Free PMC Article
    5. The E2F6 repressor activates gene expression in myocardium resulting in dilated cardiomyopathy. Westendorp B, et al. FASEB J, 2012 Jun. PMID 22403008

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GINS2 plays a protective role in alcohol-induced brain injury
      Title: GINS complex subunit 2 (GINS2) plays a protective role in alcohol-induced brain injury.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in DNA unwinding involved in DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA unwinding involved in DNA replication NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CMG complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of CMG complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of GINS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GINS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA replication complex GINS protein PSF2
    Names
    GINS complex subunit 2 (Psf2 homolog)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178856.1 → NP_849187.1  DNA replication complex GINS protein PSF2

      See identical proteins and their annotated locations for NP_849187.1

      Status: PROVISIONAL

      Source sequence(s)
      BC082565
      Consensus CDS
      CCDS40496.1
      UniProtKB/Swiss-Prot
      Q8BMT2, Q9D600
      Related
      ENSMUSP00000034278.6, ENSMUST00000034278.6
      Conserved Domains (1) summary
      cd11712
      Location:55 → 174
      GINS_A_psf2; Alpha-helical domain of GINS complex protein Psf2 (partner of Sld5 2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      121308005..121315814 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D600.1 GenPept UniProtKB/Swiss-Prot:Q9D600

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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