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    Golga1 golgin A1 [ Mus musculus (house mouse) ]

    Gene ID: 76899, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Golga1provided by MGI
    Official Full Name
    golgin A1provided by MGI
    Primary source
    MGI:MGI:1924149
    See related
    Ensembl:ENSMUSG00000026754 AllianceGenome:MGI:1924149
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    awag; Golgi97; golgin-97; 0710001G09Rik; 2210418B03Rik
    Summary
    Located in perinuclear region of cytoplasm and trans-Golgi network. Is expressed in embryo. Orthologous to human GOLGA1 (golgin A1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 8.2), whole brain E14.5 (RPKM 7.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Golga1 in Genome Data Viewer
    Location:
    2 B; 2 24.42 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (38906167..38955568, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (39016155..39065551, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5911 Neighboring gene STARR-positive B cell enhancer ABC_E4447 Neighboring gene STARR-positive B cell enhancer mm9_chr2:38866813-38867114 Neighboring gene WD repeat domain 38 Neighboring gene ribosomal protein L35 Neighboring gene actin related protein 2/3 complex, subunit 5-like Neighboring gene predicted gene, 26127 Neighboring gene STARR-positive B cell enhancer ABC_E9512 Neighboring gene suppressor of cancer cell invasion Neighboring gene predicted gene, 30067 Neighboring gene STARR-seq mESC enhancer starr_04343 Neighboring gene developmental pluripotency associated 4 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Membrane trafficking machinery components associated with the mammalian acrosome during spermiogenesis. Ramalho-Santos J, et al. Exp Cell Res, 2001 Jul 1. PMID 11412037
    2. Widespread but tissue-specific patterns of interferon-induced transmembrane protein 3 (IFITM3, FRAGILIS, MIL-1) in the mouse gastrula. Mikedis MM, et al. Gene Expr Patterns, 2013 Oct. PMID 23639725, Free PMC Article
    3. Murine CENPF interacts with syntaxin 4 in the regulation of vesicular transport. Pooley RD, et al. J Cell Sci, 2008 Oct 15. PMID 18827011, Free PMC Article
    4. A Golgi Lipid Signaling Pathway Controls Apical Golgi Distribution and Cell Polarity during Neurogenesis. Xie Z, et al. Dev Cell, 2018 Mar 26. PMID 29587143, Free PMC Article
    5. Characterization of three paralogous members of the Mammalian vaccinia related kinase family. Nichols RJ, et al. J Biol Chem, 2004 Feb 27. PMID 14645249

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Spontaneous (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC91089

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    golgin subfamily A member 1
    Names
    golgi autoantigen, golgin subfamily a, 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290649.1 → NP_001277578.1  golgin subfamily A member 1 isoform b

      See identical proteins and their annotated locations for NP_001277578.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AK163007, AL844588, BC053068
      Consensus CDS
      CCDS71049.1
      UniProtKB/TrEMBL
      Q66JW2
      Related
      ENSMUSP00000108471.3, ENSMUST00000112850.9
      Conserved Domains (2) summary
      smart00755
      Location:658 → 703
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      cl23717
      Location:230 → 293
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    2. NM_029793.2 → NP_084069.1  golgin subfamily A member 1 isoform a

      See identical proteins and their annotated locations for NP_084069.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK163007, AL844588, BC043090, BY084848
      Consensus CDS
      CCDS16016.1
      UniProtKB/Swiss-Prot
      A3KGQ9, Q80YB0, Q9CW79
      UniProtKB/TrEMBL
      Q66JW2
      Related
      ENSMUSP00000037735.9, ENSMUST00000039165.15
      Conserved Domains (2) summary
      smart00755
      Location:683 → 728
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      TIGR02168
      Location:151 → 504
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RNA

    1. NR_110968.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate segment in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK028516, AK163007, AL844588, BY084848

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      38906167..38955568 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162691.1 → XP_036018584.1  golgin subfamily A member 1 isoform X1

      UniProtKB/TrEMBL
      Q66JW2
      Conserved Domains (3) summary
      smart00755
      Location:683 → 728
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      TIGR02168
      Location:151 → 504
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      NF033930
      Location:441 → 671
      pneumo_PspA; pneumococcal surface protein A

    2. XM_030252197.2 → XP_030108057.1  golgin subfamily A member 1 isoform X2

      UniProtKB/Swiss-Prot
      A3KGQ9, Q80YB0, Q9CW79
      UniProtKB/TrEMBL
      Q66JW2
      Conserved Domains (2) summary
      smart00755
      Location:683 → 728
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      TIGR02168
      Location:151 → 504
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. XM_036162693.1 → XP_036018586.1  golgin subfamily A member 1 isoform X1

      UniProtKB/TrEMBL
      Q66JW2
      Conserved Domains (3) summary
      smart00755
      Location:683 → 728
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      TIGR02168
      Location:151 → 504
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      NF033930
      Location:441 → 671
      pneumo_PspA; pneumococcal surface protein A

    RNA

    1. XR_866026.4 RNA Sequence

    2. XR_001783203.3 RNA Sequence

    3. XR_004940769.1 RNA Sequence

    4. XR_004940768.1 RNA Sequence

    5. XR_866025.4 RNA Sequence

    6. XR_004940767.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CW79.2 GenPept UniProtKB/Swiss-Prot:Q9CW79

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