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    Mea1 male enhanced antigen 1 [ Mus musculus (house mouse) ]

    Gene ID: 17256, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mea1provided by MGI
    Official Full Name
    male enhanced antigen 1provided by MGI
    Primary source
    MGI:MGI:96957
    See related
    Ensembl:ENSMUSG00000002768 AllianceGenome:MGI:96957
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mea-1
    Summary
    Predicted to be involved in cell differentiation and spermatogenesis. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human MEA1 (male-enhanced antigen 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 378.2), CNS E18 (RPKM 37.2) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mea1 in Genome Data Viewer
    Location:
    17 C; 17 22.9 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46989699..46994052)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46678801..46683126)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cullin 7 Neighboring gene STARR-seq mESC enhancer starr_42676 Neighboring gene ribosomal RNA processing 36 Neighboring gene STARR-positive B cell enhancer mm9_chr17:46817738-46818039 Neighboring gene kelch domain containing 3 Neighboring gene protein phosphatase 2, regulatory subunit B', delta Neighboring gene STARR-positive B cell enhancer ABC_E7538 Neighboring gene peroxisomal biogenesis factor 6 Neighboring gene glycine N-methyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Male-enhanced antigen gene is phylogenetically conserved and expressed at late stages of spermatogenesis. Lau YF, et al. Proc Natl Acad Sci U S A, 1989 Nov. PMID 2813404, Free PMC Article
    2. Cloning and sequence analysis of cDNA encoding the bovine testis-derived male-enhanced antigen (Mea). Kondo M, et al. Biochim Biophys Acta, 1993 Dec 14. PMID 8268232
    3. Expression of the B56delta subunit of protein phosphatase 2A and Mea1 in mouse spermatogenesis. Identification of a new B56gamma subunit (B56gamma4) specifically expressed in testis. Ortega-Lázaro JC, et al. Cytogenet Genome Res, 2003. PMID 15051958
    4. Male-enhanced antigen-1 gene flanked by two overlapping genes is expressed in late spermatogenesis. Ohinata Y, et al. Biol Reprod, 2002 Dec. PMID 12444059
    5. High-resolution comparative mapping of mouse chromosome 17. Himmelbauer H, et al. Genomics, 1993 Jul. PMID 8406442

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. localization of the male-enhanced antigen-1 suggests that it may function in the very late stages of spermiogenesis
      Title: Male-enhanced antigen-1 gene flanked by two overlapping genes is expressed in late spermatogenesis.
    2. A comparative expression study of Mea1 and the B56delta subunit of protein phosphatase 2A in spermatogenesis.
      Title: Expression of the B56delta subunit of protein phosphatase 2A and Mea1 in mouse spermatogenesis. Identification of a new B56gamma subunit (B56gamma4) specifically expressed in testis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    male-enhanced antigen 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277309.1 → NP_001264238.1  male-enhanced antigen 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AK010904, BY510335, BY707372, CT030702
      UniProtKB/TrEMBL
      A0A3B2WB12, Q9D0Q0, Q9DB93
      Conserved Domains (1) summary
      pfam06910
      Location:42 → 215
      MEA1; Male enhanced antigen 1 (MEA1)

    2. NM_001277310.1 → NP_001264239.1  male-enhanced antigen 1 isoform b

      See identical proteins and their annotated locations for NP_001264239.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate exon in place of the first exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, 4, and 5 all encode the same isoform (b).
      Source sequence(s)
      AK010904, BG085669, BY510335, CT030702
      Consensus CDS
      CCDS28835.1
      UniProtKB/Swiss-Prot
      Q64327, Q793G4
      UniProtKB/TrEMBL
      A0A3B2WB12, Q9D0Q0, Q9DB93
      Related
      ENSMUSP00000156392.2, ENSMUST00000232732.2
      Conserved Domains (1) summary
      pfam06910
      Location:54 → 170
      MEA1; Male enhanced antigen 1 (MEA1)

    3. NM_001277311.1 → NP_001264240.1  male-enhanced antigen 1 isoform b

      See identical proteins and their annotated locations for NP_001264240.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an alternate exon in place of the first exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, 4, and 5 all encode the same isoform (b).
      Source sequence(s)
      AK010904, BY510335, CT030702
      Consensus CDS
      CCDS28835.1
      UniProtKB/Swiss-Prot
      Q64327, Q793G4
      UniProtKB/TrEMBL
      A0A3B2WB12, Q9D0Q0, Q9DB93
      Related
      ENSMUSP00000156895.2, ENSMUST00000232762.2
      Conserved Domains (1) summary
      pfam06910
      Location:54 → 170
      MEA1; Male enhanced antigen 1 (MEA1)

    4. NM_001277312.1 → NP_001264241.1  male-enhanced antigen 1 isoform b

      See identical proteins and their annotated locations for NP_001264241.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has an alternate exon in place of the first exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, 4, and 5 all encode the same isoform (b).
      Source sequence(s)
      AK010904, BY510335, CT030702
      Consensus CDS
      CCDS28835.1
      UniProtKB/Swiss-Prot
      Q64327, Q793G4
      UniProtKB/TrEMBL
      A0A3B2WB12, Q9D0Q0, Q9DB93
      Related
      ENSMUSP00000156967.2, ENSMUST00000233612.2
      Conserved Domains (1) summary
      pfam06910
      Location:54 → 170
      MEA1; Male enhanced antigen 1 (MEA1)

    5. NM_001413530.1 → NP_001400459.1  male-enhanced antigen 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      CT030702
      UniProtKB/Swiss-Prot
      Q64327, Q793G4
      UniProtKB/TrEMBL
      A0A3B2WB12, Q9D0Q0, Q9DB93

    6. NM_001413531.1 → NP_001400460.1  male-enhanced antigen 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      CT030702
      UniProtKB/Swiss-Prot
      Q64327, Q793G4
      UniProtKB/TrEMBL
      A0A3B2WB12, Q9D0Q0, Q9DB93

    7. NM_001413532.1 → NP_001400461.1  male-enhanced antigen 1 isoform c

      Status: VALIDATED

      Source sequence(s)
      CT030702
      UniProtKB/TrEMBL
      A0A3B2WB12, Q9D0Q0, Q9DB93

    8. NM_001413533.1 → NP_001400462.1  male-enhanced antigen 1 isoform c

      Status: VALIDATED

      Source sequence(s)
      CT030702
      UniProtKB/TrEMBL
      A0A3B2WB12, Q9D0Q0, Q9DB93

    9. NM_001413534.1 → NP_001400463.1  male-enhanced antigen 1 isoform d

      Status: VALIDATED

      Source sequence(s)
      CT030702
      UniProtKB/TrEMBL
      A0A3B2WD56

    10. NM_001413536.1 → NP_001400465.1  male-enhanced antigen 1 isoform d

      Status: VALIDATED

      Source sequence(s)
      CT030702
      UniProtKB/TrEMBL
      A0A3B2WD56

    11. NM_010787.2 → NP_034917.1  male-enhanced antigen 1 isoform b

      See identical proteins and their annotated locations for NP_034917.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate exon in place of the first exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, 4, and 5 all encode the same isoform (b).
      Source sequence(s)
      AK010904, BY510335, CJ042312
      Consensus CDS
      CCDS28835.1
      UniProtKB/Swiss-Prot
      Q64327, Q793G4
      UniProtKB/TrEMBL
      A0A3B2WB12, Q9D0Q0, Q9DB93
      Related
      ENSMUSP00000002845.7, ENSMUST00000002845.8
      Conserved Domains (1) summary
      pfam06910
      Location:54 → 170
      MEA1; Male enhanced antigen 1 (MEA1)

    RNA

    1. NR_102392.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK008194, BY510335, CJ042312, CT030702

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      46989699..46994052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523748.4 → XP_006523811.1  male-enhanced antigen 1 isoform X1

      See identical proteins and their annotated locations for XP_006523811.1

      UniProtKB/Swiss-Prot
      Q64327, Q793G4
      UniProtKB/TrEMBL
      A0A3B2WB12, Q9D0Q0, Q9DB93
      Conserved Domains (1) summary
      pfam06910
      Location:54 → 170
      MEA1; Male enhanced antigen 1 (MEA1)

    2. XM_006523750.5 → XP_006523813.1  male-enhanced antigen 1 isoform X1

      See identical proteins and their annotated locations for XP_006523813.1

      UniProtKB/Swiss-Prot
      Q64327, Q793G4
      UniProtKB/TrEMBL
      A0A3B2WB12, Q9D0Q0, Q9DB93
      Conserved Domains (1) summary
      pfam06910
      Location:54 → 170
      MEA1; Male enhanced antigen 1 (MEA1)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64327.1 GenPept UniProtKB/Swiss-Prot:Q64327

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