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    Mob4 MOB family member 4, phocein [ Mus musculus (house mouse) ]

    Gene ID: 19070, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mob4provided by MGI
    Official Full Name
    MOB family member 4, phoceinprovided by MGI
    Primary source
    MGI:MGI:104899
    See related
    Ensembl:ENSMUSG00000025979 AllianceGenome:MGI:104899
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Phocn; Prei3; Mobkl3; 2610109B12Rik
    Summary
    Predicted to enable kinase binding activity and protein-macromolecule adaptor activity. Predicted to be involved in negative regulation of hippo signaling. Is active in glutamatergic synapse and postsynapse. Is expressed in early conceptus; primary oocyte; and secondary oocyte. Orthologous to human MOB4 (MOB family member 4, phocein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 17.4), bladder adult (RPKM 17.1) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mob4 in Genome Data Viewer
    Location:
    1 C1.2; 1 28.03 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (55170404..55194058)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (55131245..55154899)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7A pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:55187824-55188011 Neighboring gene serine/arginine repetitive matrix 2 pseudogene Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g pseudogene Neighboring gene raftlin family member 2 Neighboring gene STARR-seq mESC enhancer starr_00949 Neighboring gene STARR-positive B cell enhancer ABC_E11071 Neighboring gene predicted gene 10561

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Immunogold localization of phocein in dendritic spines. Haeberlé AM, et al. J Comp Neurol, 2006 Mar 20. PMID 16440294
    2. A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes. Moreno CS, et al. J Biol Chem, 2001 Jun 29. PMID 11319234, Free PMC Article
    3. CTTNBP2, but not CTTNBP2NL, regulates dendritic spinogenesis and synaptic distribution of the striatin-PP2A complex. Chen YK, et al. Mol Biol Cell, 2012 Nov. PMID 23015759, Free PMC Article
    4. Expression patterns of novel genes during mouse preimplantation embryogenesis. Temeles GL, et al. Mol Reprod Dev, 1994 Feb. PMID 7545925
    5. 140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry. Berggård T, et al. J Proteome Res, 2006 Mar. PMID 16512683

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of hippo signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of hippo signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of FAR/SIN/STRIPAK complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MOB-like protein phocein
    Names
    MOB1, Mps One Binder kinase activator-like 3
    class II mMOB1
    mob1 homolog 3
    mob3
    mps one binder kinase activator-like 3
    preimplantation protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310585.1 → NP_001297514.1  MOB-like protein phocein isoform 2

      See identical proteins and their annotated locations for NP_001297514.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BC052475, BE333014, BY128391
      Consensus CDS
      CCDS78585.1
      UniProtKB/TrEMBL
      E0CXA9, Q3UGM5
      Related
      ENSMUSP00000124790.2, ENSMUST00000159311.8
      Conserved Domains (1) summary
      pfam03637
      Location:32 → 186
      Mob1_phocein; Mob1/phocein family

    2. NM_025283.3 → NP_079559.2  MOB-like protein phocein isoform 1

      See identical proteins and their annotated locations for NP_079559.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC052475, BY768556
      Consensus CDS
      CCDS14960.1
      UniProtKB/Swiss-Prot
      Q3TS21, Q6PEB6, Q8BSA3, Q9CX28
      UniProtKB/TrEMBL
      Q3UGM5
      Related
      ENSMUSP00000125415.2, ENSMUST00000162364.8
      Conserved Domains (1) summary
      pfam03637
      Location:53 → 207
      Mob1_phocein; Mob1/phocein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      55170404..55194058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PEB6.1 GenPept UniProtKB/Swiss-Prot:Q6PEB6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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