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    Plaat1 phospholipase A and acyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 27281, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plaat1provided by MGI
    Official Full Name
    phospholipase A and acyltransferase 1provided by MGI
    Primary source
    MGI:MGI:1351473
    See related
    Ensembl:ENSMUSG00000022525 AllianceGenome:MGI:1351473
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A-C1; HRSL1; Hrasls; Hrasrs; 2810012B06Rik
    Summary
    Enables phospholipase activity. Acts upstream of or within ether lipid metabolic process and peroxisome organization. Located in nuclear envelope lumen and peroxisome. Orthologous to human PLAAT1 (phospholipase A and acyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 44.5), heart adult (RPKM 3.7) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plaat1 in Genome Data Viewer
    Location:
    16 B2; 16 20.01 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (29027883..29049283)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (29209133..29230531)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene Mab-21 domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_40518 Neighboring gene STARR-seq mESC enhancer starr_40520 Neighboring gene predicted gene 8253 Neighboring gene STARR-seq mESC enhancer starr_40521 Neighboring gene ATPase type 13A5 Neighboring gene STARR-seq mESC enhancer starr_40522 Neighboring gene STARR-seq mESC enhancer starr_40523 Neighboring gene ATPase type 13A4 Neighboring gene zinc finger protein 788 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:29579308-29579525 Neighboring gene STARR-seq mESC enhancer starr_40527 Neighboring gene OPA1, mitochondrial dynamin like GTPase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PLAAT1 Exhibits Phosphatidylcholine:Monolysocardiolipin Transacylase Activity. Bradley RM, et al. Int J Mol Sci, 2022 Jun 16. PMID 35743156, Free PMC Article
    2. PLAAT1 deficiency alleviates high-fat diet-induced hepatic lipid accumulation in mice. Rahman SMK, et al. FASEB J, 2023 Jul. PMID 37330992
    3. Comparative analyses of isoforms of the calcium-independent phosphatidylethanolamine N-acyltransferase PLAAT-1 in humans and mice. Hussain Z, et al. J Lipid Res, 2016 Nov. PMID 27623847, Free PMC Article
    4. Involvement of phospholipase A/acyltransferase-1 in N-acylphosphatidylethanolamine generation. Uyama T, et al. Biochim Biophys Acta, 2013 Dec. PMID 23994608
    5. Enzymological analysis of the tumor suppressor A-C1 reveals a novel group of phospholipid-metabolizing enzymes. Shinohara N, et al. J Lipid Res, 2011 Nov. PMID 21880860, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PLAAT1 deficiency alleviates high-fat diet-induced hepatic lipid accumulation in mice.
      Title: PLAAT1 deficiency alleviates high-fat diet-induced hepatic lipid accumulation in mice.
    2. PLAAT1 Exhibits Phosphatidylcholine:Monolysocardiolipin Transacylase Activity.
      Title: PLAAT1 Exhibits Phosphatidylcholine:Monolysocardiolipin Transacylase Activity.
    3. a possible enzyme activity of A-C1
      Title: Enzymological analysis of the tumor suppressor A-C1 reveals a novel group of phospholipid-metabolizing enzymes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables O-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables calcium-dependent phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-independent phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylserine 1-acylhydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase A1 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase A1 activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipase A1 activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipase A2 activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phospholipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acylphosphatidylethanolamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-acylphosphatidylethanolamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within Ras protein signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within ether lipid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lens fiber cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organelle disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within peroxisome organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylcholine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylcholine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of cell growth TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear envelope lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phospholipase A and acyltransferase 1
    Names
    HRAS-like suppressor 1
    Harvey rat sarcoma virus oncogene related suppressor
    phospholipid-metabolizing enzyme A-C1
    NP_001344021.1
    NP_001348218.1
    NP_038779.2
    XP_017172511.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357092.2 → NP_001344021.1  phospholipase A and acyltransferase 1

      Status: VALIDATED

      Source sequence(s)
      AC154421
      Consensus CDS
      CCDS28094.1
      UniProtKB/Swiss-Prot
      Q5D099, Q9D0S3, Q9QZU4
      UniProtKB/TrEMBL
      A0A0R4J130
      Related
      ENSMUSP00000123809.2, ENSMUST00000162747.8
      Conserved Domains (1) summary
      pfam04970
      Location:27 → 130
      LRAT; Lecithin retinol acyltransferase

    2. NM_001361289.2 → NP_001348218.1  phospholipase A and acyltransferase 1

      Status: VALIDATED

      Source sequence(s)
      AC154421
      Consensus CDS
      CCDS28094.1
      UniProtKB/Swiss-Prot
      Q5D099, Q9D0S3, Q9QZU4
      UniProtKB/TrEMBL
      A0A0R4J130
      Conserved Domains (1) summary
      pfam04970
      Location:27 → 130
      LRAT; Lecithin retinol acyltransferase

    3. NM_013751.7 → NP_038779.2  phospholipase A and acyltransferase 1

      See identical proteins and their annotated locations for NP_038779.2

      Status: VALIDATED

      Source sequence(s)
      AC154421
      Consensus CDS
      CCDS28094.1
      UniProtKB/Swiss-Prot
      Q5D099, Q9D0S3, Q9QZU4
      UniProtKB/TrEMBL
      A0A0R4J130
      Related
      ENSMUSP00000087257.5, ENSMUST00000089824.11
      Conserved Domains (1) summary
      pfam04970
      Location:27 → 130
      LRAT; Lecithin retinol acyltransferase

    RNA

    1. NR_154594.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154421

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      29027883..29049283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317022.3 → XP_017172511.1  phospholipase A and acyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5D099, Q9D0S3, Q9QZU4
      UniProtKB/TrEMBL
      A0A0R4J130
      Conserved Domains (1) summary
      pfam04970
      Location:27 → 130
      LRAT; Lecithin retinol acyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZU4.1 GenPept UniProtKB/Swiss-Prot:Q9QZU4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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