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    Golim4 golgi integral membrane protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 73124, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Golim4provided by MGI
    Official Full Name
    golgi integral membrane protein 4provided by MGI
    Primary source
    MGI:MGI:1920374
    See related
    Ensembl:ENSMUSG00000034109 AllianceGenome:MGI:1920374
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P138; GIMPC; GPP130; Golph4; 3110027H23Rik
    Summary
    Predicted to be located in Golgi cisterna membrane; Golgi membrane; and endosome membrane. Predicted to be active in Golgi apparatus and membrane. Is expressed in cerebral cortex; coronary artery; lymphatic system; and skin. Orthologous to human GOLIM4 (golgi integral membrane protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 25.8), limb E14.5 (RPKM 15.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Golim4 in Genome Data Viewer
    Location:
    3 E3; 3 33.76 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (75783490..75864256, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (75876183..75956956, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07971 Neighboring gene pluripotency associated transcript 10 Neighboring gene STARR-positive B cell enhancer ABC_E9553 Neighboring gene STARR-positive B cell enhancer mm9_chr3:75547372-75547672 Neighboring gene predicted gene, 25846 Neighboring gene STARR-seq mESC enhancer starr_07973 Neighboring gene STARR-positive B cell enhancer ABC_E11194 Neighboring gene STARR-positive B cell enhancer ABC_E1260 Neighboring gene STARR-positive B cell enhancer mm9_chr3:75805184-75805484 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene follistatin-like 5 Neighboring gene VISTA enhancer mm1370 Neighboring gene STARR-seq mESC enhancer starr_07975

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Segregation of NF-kappaB activation through NEMO/IKKgamma by Tax and TNFalpha: implications for stimulus-specific interruption of oncogenic signaling. Iha H, et al. Oncogene, 2003 Dec 4. PMID 14654787
    2. Pkd1 and Wnt5a genetically interact to control lymphatic vascular morphogenesis in mice. Chau TCY, et al. Dev Dyn, 2022 Feb. PMID 34174014
    3. Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow. Betterman KL, et al. J Clin Invest, 2020 Jun 1. PMID 32182215, Free PMC Article
    4. DACH1 stimulates shear stress-guided endothelial cell migration and coronary artery growth through the CXCL12-CXCR4 signaling axis. Chang AH, et al. Genes Dev, 2017 Jul 1. PMID 28779009, Free PMC Article
    5. Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation. Lutter S, et al. J Cell Biol, 2012 Jun 11. PMID 22665518, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102202

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Golgi integral membrane protein 4
    Names
    decapacitation factor 10
    golgi phosphoprotein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291069.1 → NP_001277998.1  Golgi integral membrane protein 4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC161369, AK078928
      Consensus CDS
      CCDS71251.1
      UniProtKB/TrEMBL
      D3YVW2
      Related
      ENSMUSP00000114006.2, ENSMUST00000117242.8
      Conserved Domains (1) summary
      cl23765
      Location:67 → 213
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    2. NM_175193.6 → NP_780402.1  Golgi integral membrane protein 4 isoform 2

      See identical proteins and their annotated locations for NP_780402.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC161369, AC167173, BC086642
      Consensus CDS
      CCDS17416.1
      UniProtKB/Swiss-Prot
      Q8BWP9, Q8BXA1
      Related
      ENSMUSP00000048997.8, ENSMUST00000038563.14
      Conserved Domains (1) summary
      cl23720
      Location:113 → 214
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      75783490..75864256 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BXA1.1 GenPept UniProtKB/Swiss-Prot:Q8BXA1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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