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    Itm2c integral membrane protein 2C [ Mus musculus (house mouse) ]

    Gene ID: 64294, updated on 9-Dec-2024

    Summary

    Official Symbol
    Itm2cprovided by MGI
    Official Full Name
    integral membrane protein 2Cprovided by MGI
    Primary source
    MGI:MGI:1927594
    See related
    Ensembl:ENSMUSG00000026223 AllianceGenome:MGI:1927594
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E25; BRI3; E25C; ITM3; Bricd2c; 3110038L02Rik
    Summary
    Enables ATP binding activity. Involved in positive regulation of extrinsic apoptotic signaling pathway. Located in lysosome. Is expressed in several structures, including central nervous system; genitourinary system; and retina. Orthologous to human ITM2C (integral membrane protein 2C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 251.4), cortex adult (RPKM 160.0) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Itm2c in Genome Data Viewer
    Location:
    1 C5; 1 43.94 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (85822231..85836419)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (85894510..85908698)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01553 Neighboring gene microRNA 8096 Neighboring gene RIKEN cDNA 9930111H07 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:87690750-87690933 Neighboring gene calcium binding protein 39 Neighboring gene STARR-positive B cell enhancer ABC_E3285 Neighboring gene STARR-seq mESC enhancer starr_01556 Neighboring gene RIKEN cDNA 4933407L21 gene Neighboring gene predicted gene, 32302 Neighboring gene predicted gene, 51745

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5)  1 citation
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables amyloid-beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables amyloid-beta binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    integral membrane protein 2C
    Names
    integral membrane protein 3
    transmembrane protein BRI3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022417.3NP_071862.2  integral membrane protein 2C

      See identical proteins and their annotated locations for NP_071862.2

      Status: VALIDATED

      Source sequence(s)
      AK036377, BE991371, BY255015
      Consensus CDS
      CCDS35641.1
      UniProtKB/Swiss-Prot
      Q91VK4, Q9JI06, Q9JME8
      UniProtKB/TrEMBL
      Q3U0F3
      Related
      ENSMUSP00000027425.10, ENSMUST00000027425.16
      Conserved Domains (1) summary
      smart01039
      Location:138230
      BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      85822231..85836419
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)