Panx3 pannexin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Panx3provided by MGI
Official Full Name: pannexin 3provided by MGI
Primary source: MGI:MGI:1918881
See related: Ensembl:ENSMUSG00000011118 AllianceGenome:MGI:1918881
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 3230401P04; 4833413G11Rik
Summary: Enables calcium channel activity and gap junction hemi-channel activity. Involved in osteoblast differentiation. Located in endoplasmic reticulum membrane; gap junction; and plasma membrane. Is expressed in several structures, including alimentary system; connective tissue; limb; sensory organ; and skeleton. Orthologous to human PANX3 (pannexin 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in limb E14.5 (RPKM 14.6) and CNS E14 (RPKM 1.6) See more
Orthologs: human all
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Genomic context

Location:: 9 A4; 9 20.79 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (37571198..37580518, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (37659902..37669222, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Contribution of inwardly rectifying potassium channel 4.1 in orofacial neuropathic pain: Regulation of pannexin 3 via the reactive oxygen species-activated P38 MAPK signal pathway.
Title: Contribution of inwardly rectifying potassium channel 4.1 in orofacial neuropathic pain: Regulation of pannexin 3 via the reactive oxygen species-activated P38 MAPK signal pathway.
Pannexin-3 stabilizes the transcription factor Bcl6 in a channel-independent manner to protect against vascular oxidative stress.
Title: Pannexin-3 stabilizes the transcription factor Bcl6 in a channel-independent manner to protect against vascular oxidative stress.
PANX3 Channels Regulate Architecture, Adhesion, Barrier Function, and Inflammation in the Skin.
Title: PANX3 Channels Regulate Architecture, Adhesion, Barrier Function, and Inflammation in the Skin.
Pannexin 3 regulates skin development via Epiprofin.
Title: Pannexin 3 regulates skin development via Epiprofin.
Global Deletion of Pannexin 3 Resulting in Accelerated Development of Aging-Induced Osteoarthritis in Mice.
Title: Global Deletion of Pannexin 3 Resulting in Accelerated Development of Aging-Induced Osteoarthritis in Mice.
The Role of Panx3 in Age-Associated and Injury-Induced Intervertebral Disc Degeneration.
Title: The Role of Panx3 in Age-Associated and Injury-Induced Intervertebral Disc Degeneration.
Pannexin 3 ER Ca(2+) channel gating is regulated by phosphorylation at the Serine 68 residue in osteoblast differentiation.
Title: Pannexin 3 ER Ca(2+) channel gating is regulated by phosphorylation at the Serine 68 residue in osteoblast differentiation.
Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling.
Title: Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling.
These findings suggest that Panx1 and Panx3 are important at early stages of development in the skin and bone but may be redundant in the auditory system.
Title: Double deletion of Panx1 and Panx3 affects skin and bone but not hearing.
Panx3 plays a key role in the skin wound healing process by controlling keratinocytes and keratinocyte-mesenchyme cross-talk via hemichannel and endoplasmic reticulum Ca(2+) channel functions, which differs from another gap junction, connexin 43 (Cx43), during skin wound healing.
Title: Pannexin-3 Deficiency Delays Skin Wound Healing in Mice due to Defects in Channel Functionality.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (5) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables gap junction hemi-channel activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables gap junction hemi-channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables structural molecule activity	ISS Inferred from Sequence or Structural Similarity more info
enables wide pore channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell signaling	IEA Inferred from Electronic Annotation more info
involved_in cell-cell signaling	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-1 production	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in gap junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: pannexin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.