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    Pibf1 progesterone immunomodulatory binding factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 52023, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pibf1provided by MGI
    Official Full Name
    progesterone immunomodulatory binding factor 1provided by MGI
    Primary source
    MGI:MGI:1261910
    See related
    Ensembl:ENSMUSG00000022064 AllianceGenome:MGI:1261910
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable interleukin-4 receptor binding activity. Predicted to be involved in several processes, including mitotic sister chromatid segregation; regulation of cytokine production; and regulation of protein phosphorylation. Predicted to be located in centriolar satellite; extracellular space; and nucleus. Predicted to be active in microtubule organizing center. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Human ortholog(s) of this gene implicated in Joubert syndrome 33. Orthologous to human PIBF1 (progesterone immunomodulatory binding factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 4.5), ovary adult (RPKM 3.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pibf1 in Genome Data Viewer
    Location:
    14 E2.2; 14 49.27 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (99336892..99492335)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (99099424..99254899)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36A, pseudogene 1 Neighboring gene VISTA enhancer mm829 Neighboring gene STARR-seq mESC enhancer starr_37425 Neighboring gene STARR-positive B cell enhancer ABC_E1902 Neighboring gene mitotic spindle organizing protein 1 Neighboring gene bora, aurora kinase A activator Neighboring gene STARR-positive B cell enhancer ABC_E5462 Neighboring gene STARR-seq mESC enhancer starr_37426 Neighboring gene DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease Neighboring gene STARR-seq mESC enhancer starr_37427 Neighboring gene STARR-seq mESC enhancer starr_37430 Neighboring gene STARR-seq mESC enhancer starr_37436 Neighboring gene Kruppel-like transcription factor 5 Neighboring gene STARR-seq mESC enhancer starr_37437 Neighboring gene predicted gene, 22984

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PIBF+ extracellular vesicles from mouse embryos affect IL-10 production by CD8+ cells. Pallinger E, et al. Sci Rep, 2018 Mar 16. PMID 29549351, Free PMC Article
    2. Knockout mice created by TALEN-mediated gene targeting. Sung YH, et al. Nat Biotechnol, 2013 Jan. PMID 23302927
    3. Interleukin-33-induced expression of PIBF1 by decidual B cells protects against preterm labor. Huang B, et al. Nat Med, 2017 Jan. PMID 27918564, Free PMC Article
    4. Tissue gene expression analysis using arrayed normalized cDNA libraries. Eickhoff H, et al. Genome Res, 2000 Aug. PMID 10958641, Free PMC Article
    5. A ciliopathy complex builds distal appendages to initiate ciliogenesis. Kumar D, et al. J Cell Biol, 2021 Sep 6. PMID 34241634, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development.
      Title: PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development.
    2. Data suggest, that PIBF transported by the extracellular vesicles( EVs) from the embryo to maternal lymphocytes might induce increased IL-10 production by the latter, this way contributing to the Th2 dominant immune responses described during pregnancy.
      Title: PIBF+ extracellular vesicles from mouse embryos affect IL-10 production by CD8+ cells.
    3. B cell deficiency in mice resulted in a lower uterine level of active progesterone-induced blocking factor 1 (PIBF1), and susceptibility to preterm labor after inflammation. B cells are a significant producer of PIBF1 in mouse uterus in late gestation.
      Title: Interleukin-33-induced expression of PIBF1 by decidual B cells protects against preterm labor.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • 1700017E21Rik, 4930513H15Rik, 4933438D16Rik, 4933439E17Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables interleukin-4 receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of Janus kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-12 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of natural killer cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of prostaglandin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in non-motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    progesterone-induced-blocking factor 1
    Names
    progesterone-induced blocking factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029320.4 → NP_083596.2  progesterone-induced-blocking factor 1

      Status: VALIDATED

      Source sequence(s)
      AC154843, AC165154
      Consensus CDS
      CCDS36997.1
      UniProtKB/TrEMBL
      E9Q6K3
      Related
      ENSMUSP00000022650.8, ENSMUST00000022650.9
      Conserved Domains (1) summary
      pfam01496
      Location:475 → 558
      V_ATPase_I; V-type ATPase 116kDa subunit family

    RNA

    1. NR_188872.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154843, AC165154

    2. NR_188873.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154843, AC165154

    3. NR_188874.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154843, AC165154

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      99336892..99492335
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519256.5 → XP_006519319.1  progesterone-induced-blocking factor 1 isoform X5

      UniProtKB/TrEMBL
      Q8BIR5
      Conserved Domains (1) summary
      TIGR02168
      Location:125 → 406
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_006519253.5 → XP_006519316.1  progesterone-induced-blocking factor 1 isoform X3

      Conserved Domains (2) summary
      TIGR02168
      Location:234 → 572
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:44 → 355
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    3. XM_036158751.1 → XP_036014644.1  progesterone-induced-blocking factor 1 isoform X1

      Conserved Domains (2) summary
      COG1196
      Location:21 → 684
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:234 → 538
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RNA

    1. XR_003950865.2 RNA Sequence

    2. XR_383193.5 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_029454.4: Suppressed sequence

      Description
      NM_029454.4: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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