Denr density-regulated protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Denrprovided by MGI
Official Full Name: density-regulated proteinprovided by MGI
Primary source: MGI:MGI:1915434
See related: Ensembl:ENSMUSG00000023106 AllianceGenome:MGI:1915434
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1500003K04Rik
Summary: Predicted to enable translation initiation factor activity. Predicted to be involved in IRES-dependent viral translational initiation; cytoplasmic translational initiation; and ribosome disassembly. Predicted to be active in cytoplasm. Is expressed in embryo. Orthologous to human DENR (density regulated re-initiation and release factor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E11.5 (RPKM 21.0), liver E14 (RPKM 12.7) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 63.26 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (124045309..124066705)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (123907205..123928832)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Clock is a DENR target in mouse circadian timekeeping
Title: Charting DENR-dependent translation reinitiation uncovers predictive uORF features and links to circadian timekeeping via Clock.
Denr influences the migration of murine cerebral cortical neurons in vivo with its binding partner Mcts1.
Title: De Novo Mutations in DENR Disrupt Neuronal Development and Link Congenital Neurological Disorders to Faulty mRNA Translation Re-initiation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in IRES-dependent viral translational initiation	IEA Inferred from Electronic Annotation more info
involved_in IRES-dependent viral translational initiation	ISO Inferred from Sequence Orthology more info
involved_in formation of translation preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in formation of translation preinitiation complex	IEA Inferred from Electronic Annotation more info
involved_in formation of translation preinitiation complex	ISO Inferred from Sequence Orthology more info
involved_in ribosome disassembly	IEA Inferred from Electronic Annotation more info
involved_in ribosome disassembly	ISO Inferred from Sequence Orthology more info
involved_in translation reinitiation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: density-regulated protein

Names: DRP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417688.1 → NP_001404617.1 density-regulated protein isoform a

Status: VALIDATED

Source sequence(s)

AC122753

UniProtKB/Swiss-Prot

Q3UXY1, Q9CQJ6

UniProtKB/TrEMBL

E9Q0G1

Related

ENSMUSP00000126174.2, ENSMUST00000166233.2
NM_001417689.1 → NP_001404618.1 density-regulated protein isoform b

Status: VALIDATED

Source sequence(s)

AC122753
NM_001417690.1 → NP_001404619.1 density-regulated protein isoform c

Status: VALIDATED

Source sequence(s)

AC122753
NM_001417691.1 → NP_001404620.1 density-regulated protein isoform c

Status: VALIDATED

Source sequence(s)

AC122753
NM_001417692.1 → NP_001404621.1 density-regulated protein isoform d

Status: VALIDATED

Source sequence(s)

AC122753
NM_026603.5 → NP_080879.1 density-regulated protein isoform a

See identical proteins and their annotated locations for NP_080879.1

Status: VALIDATED

Source sequence(s)

AC122753

Consensus CDS

CCDS39275.1

UniProtKB/Swiss-Prot

Q3UXY1, Q9CQJ6

UniProtKB/TrEMBL

E9Q0G1

Related

ENSMUSP00000023869.9, ENSMUST00000023869.15

Conserved Domains (1) summary

TIGR01159
Location:28 → 193

DRP1; density-regulated protein DRP1