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    Garin5a golgi associated RAB2 interactor 5A [ Mus musculus (house mouse) ]

    Gene ID: 75538, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Garin5aprovided by MGI
    Official Full Name
    golgi associated RAB2 interactor 5Aprovided by MGI
    Primary source
    MGI:MGI:1922788
    See related
    Ensembl:ENSMUSG00000051113 AllianceGenome:MGI:1922788
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GARIL5; Fam71e1; GARI-L5; 0610007G24Rik; 1700021N13Rik; 1700021P22Rik
    Summary
    Involved in defense response to virus; innate immune response; and positive regulation of type I interferon production. Acts upstream of or within cell morphogenesis; single fertilization; and vacuole organization. Located in Golgi apparatus. Is active in sperm head. Orthologous to human GARIN5A (golgi associated RAB2 interactor 5A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 95.9) and mammary gland adult (RPKM 4.1) See more
    Orthologs
    human all
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    Genomic context

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    See Garin5a in Genome Data Viewer
    Location:
    7 B3; 7 28.83 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44145923..44153690)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44496499..44504266)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Josephin domain containing 2 Neighboring gene microRNA 7052 Neighboring gene RIKEN cDNA 5430431A17 gene Neighboring gene STARR-seq mESC enhancer starr_18800 Neighboring gene ER membrane protein complex subunit 10 Neighboring gene myosin binding protein C, fast-type Neighboring gene STARR-positive B cell enhancer ABC_E10437 Neighboring gene Spi-B transcription factor (Spi-1/PU.1 related) Neighboring gene polymerase (DNA directed), delta 1, catalytic subunit Neighboring gene microRNA 7053

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses. Takahama M, et al. Cell Rep, 2017 Sep 19. PMID 28930687, Free PMC Article
    2. Golgi associated RAB2 interactor protein family contributes to murine male fertility to various extents by assuring correct morphogenesis of sperm heads. Wang H, et al. PLoS Genet, 2024 Jun. PMID 38935810, Free PMC Article
    3. Large scale screening for novel rab effectors reveals unexpected broad Rab binding specificity. Fukuda M, et al. Mol Cell Proteomics, 2008 Jun. PMID 18256213
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the RAB2B-GARIL5 complex promotes IFN responses against DNA viruses by regulating the cGAS-STING signaling axis.
      Title: The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC161173

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of type I interferon production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vacuole organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in sperm head IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Golgi-associated RAB2 interactor protein 5A
    Names
    Golgi associated RAB2 interactor protein 5A
    Golgi-associated Rab2B interactor-like 5
    Protein FAM71E1
    family with sequence similarity 71, member E1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357650.2 → NP_001344579.1  Golgi-associated RAB2 interactor protein 5A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC149607
      Conserved Domains (1) summary
      pfam12480
      Location:28 → 92
      DUF3699; Protein of unknown function (DUF3699)

    2. NM_001357651.2 → NP_001344580.1  Golgi-associated RAB2 interactor protein 5A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC149607
      UniProtKB/TrEMBL
      B7XG50
      Conserved Domains (1) summary
      pfam12480
      Location:113 → 177
      DUF3699; Protein of unknown function (DUF3699)

    3. NM_001368290.1 → NP_001355219.1  Golgi-associated RAB2 interactor protein 5A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC149607
      UniProtKB/TrEMBL
      B7XG50

    4. NM_001368291.1 → NP_001355220.1  Golgi-associated RAB2 interactor protein 5A isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC149607
      UniProtKB/TrEMBL
      B7XG50

    5. NM_001368292.1 → NP_001355221.1  Golgi-associated RAB2 interactor protein 5A isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC149607
      Conserved Domains (1) summary
      pfam12480
      Location:2 → 61
      DUF3699; Protein of unknown function (DUF3699)

    6. NM_028169.2 → NP_082445.1  Golgi-associated RAB2 interactor protein 5A isoform 1

      See identical proteins and their annotated locations for NP_082445.1

      Status: VALIDATED

      Source sequence(s)
      AC149607
      Consensus CDS
      CCDS52232.1
      UniProtKB/Swiss-Prot
      A1L3C1, E9QKI6, Q0P5X9
      UniProtKB/TrEMBL
      B7XG50
      Related
      ENSMUSP00000103560.4, ENSMUST00000107927.5
      Conserved Domains (1) summary
      pfam12480
      Location:93 → 158
      DUF3699; Protein of unknown function (DUF3699)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44145923..44153690
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243055.2 → XP_030098915.1  Golgi-associated RAB2 interactor protein 5A isoform X10

      Conserved Domains (1) summary
      pfam12480
      Location:2 → 61
      DUF3699; Protein of unknown function (DUF3699)

    2. XM_006541242.3 → XP_006541305.1  Golgi-associated RAB2 interactor protein 5A isoform X1

      Conserved Domains (1) summary
      pfam12480
      Location:118 → 177
      DUF3699; Protein of unknown function (DUF3699)

    3. XM_006541243.4 → XP_006541306.1  Golgi-associated RAB2 interactor protein 5A isoform X3

      UniProtKB/TrEMBL
      A0A0U1RNU0
      Related
      ENSMUSP00000145700.2, ENSMUST00000205359.2
      Conserved Domains (1) summary
      pfam12480
      Location:99 → 158
      DUF3699; Protein of unknown function (DUF3699)

    4. XM_036153517.1 → XP_036009410.1  Golgi-associated RAB2 interactor protein 5A isoform X7

      UniProtKB/TrEMBL
      B7XG50
      Conserved Domains (1) summary
      pfam12480
      Location:99 → 158
      DUF3699; Protein of unknown function (DUF3699)

    5. XM_036153516.1 → XP_036009409.1  Golgi-associated RAB2 interactor protein 5A isoform X5

      Conserved Domains (1) summary
      pfam12480
      Location:99 → 158
      DUF3699; Protein of unknown function (DUF3699)

    6. XM_030243057.2 → XP_030098917.1  Golgi-associated RAB2 interactor protein 5A isoform X12

      Conserved Domains (1) summary
      pfam12480
      Location:33 → 92
      DUF3699; Protein of unknown function (DUF3699)

    7. XM_030243059.2 → XP_030098919.1  Golgi-associated RAB2 interactor protein 5A isoform X14

      Conserved Domains (1) summary
      pfam12480
      Location:2 → 61
      DUF3699; Protein of unknown function (DUF3699)

    8. XM_036153519.1 → XP_036009412.1  Golgi-associated RAB2 interactor protein 5A isoform X15

      Conserved Domains (1) summary
      pfam12480
      Location:2 → 61
      DUF3699; Protein of unknown function (DUF3699)

    9. XM_030243058.2 → XP_030098918.1  Golgi-associated RAB2 interactor protein 5A isoform X13

      Conserved Domains (1) summary
      pfam12480
      Location:2 → 61
      DUF3699; Protein of unknown function (DUF3699)

    10. XM_006541248.3 → XP_006541311.1  Golgi-associated RAB2 interactor protein 5A isoform X9

      Conserved Domains (1) summary
      pfam12480
      Location:33 → 92
      DUF3699; Protein of unknown function (DUF3699)

    11. XM_036153518.1 → XP_036009411.1  Golgi-associated RAB2 interactor protein 5A isoform X11

      Conserved Domains (1) summary
      pfam12480
      Location:33 → 92
      DUF3699; Protein of unknown function (DUF3699)

    12. XM_011250907.4 → XP_011249209.1  Golgi-associated RAB2 interactor protein 5A isoform X8

      UniProtKB/TrEMBL
      B7XG50
      Conserved Domains (1) summary
      pfam12480
      Location:118 → 177
      DUF3699; Protein of unknown function (DUF3699)

    13. XM_036153515.1 → XP_036009408.1  Golgi-associated RAB2 interactor protein 5A isoform X2

      Conserved Domains (1) summary
      pfam12480
      Location:118 → 177
      DUF3699; Protein of unknown function (DUF3699)

    14. XM_006541244.5 → XP_006541307.1  Golgi-associated RAB2 interactor protein 5A isoform X4

      Conserved Domains (1) summary
      pfam12480
      Location:118 → 177
      DUF3699; Protein of unknown function (DUF3699)

    15. XM_006541245.5 → XP_006541308.1  Golgi-associated RAB2 interactor protein 5A isoform X6

      Conserved Domains (1) summary
      pfam12480
      Location:118 → 177
      DUF3699; Protein of unknown function (DUF3699)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1L3C1.2 GenPept UniProtKB/Swiss-Prot:A1L3C1

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