Hdac1l histone deacetylase 1-like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hdac1lprovided by RGD
Official Full Name: histone deacetylase 1-likeprovided by RGD
Primary source: RGD:619975
See related: EnsemblRapid:ENSRNOG00000013695 AllianceGenome:RGD:619975
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable histone deacetylase activity. Predicted to be involved in heterochromatin formation. Predicted to be part of NuRD complex. Predicted to be active in nucleus. Orthologous to human HDAC1 (histone deacetylase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 9q34

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (87901045..87903045, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (80452615..80454615, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (84893145..84894599, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of HDAC1 in mouse embryonic stem cells results in reduced proliferation.
Title: Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hdac1 (e-PCR), detects polymorphism
- UniSTS:495836

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables histone H3K14 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H3K4 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H3K9 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H4K12 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H4K16 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H4K5 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H4K8 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein decrotonylase activity	IEA Inferred from Electronic Annotation more info
enables tubulin deacetylase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of NuRD complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: histone deacetylase 1-like

NP_445898.1

EC 3.5.1.98

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053446.2 → NP_445898.1 histone deacetylase 1-like

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

D3ZVU7

Related

ENSRNOP00000018423.5, ENSRNOT00000018423.7

Conserved Domains (1) summary

cd10010
Location:4 → 376

HDAC1; Histone deacetylase 1 (HDAC1)