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    VGLL1 vestigial like family member 1 [ Homo sapiens (human) ]

    Gene ID: 51442, updated on 10-Dec-2024

    Summary

    Official Symbol
    VGLL1provided by HGNC
    Official Full Name
    vestigial like family member 1provided by HGNC
    Primary source
    HGNC:HGNC:20985
    See related
    Ensembl:ENSG00000102243 MIM:300583; AllianceGenome:HGNC:20985
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TDU; VGL1
    Summary
    The protein encoded by this gene binds proteins of the TEA domain family of transcription factors (TEFs) through the Vg (vestigial) homology region found in its N-terminus. It may thus function as a specific coactivator for the mammalian TEFs. [provided by RefSeq, Sep 2009]
    Expression
    Restricted expression toward placenta (RPKM 103.1) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See VGLL1 in Genome Data Viewer
    Location:
    Xq26.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (136532215..136556799)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (134840972..134865547)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (135614374..135638958)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21027 Neighboring gene bombesin receptor subtype 3 Neighboring gene HIV-1 Tat specific factor 1 Neighboring gene microRNA 934 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29989 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29991 Neighboring gene RNA, U6 small nuclear 320, pseudogene Neighboring gene long intergenic non-protein coding RNA 892

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription cofactor vestigial-like protein 1
    Names
    TONDU
    WUGSC:H_GS188P18.1b
    vestigial like 1
    vgl-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013270.2 RefSeqGene

      Range
      5064..29648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_016267.4NP_057351.1  transcription cofactor vestigial-like protein 1

      See identical proteins and their annotated locations for NP_057351.1

      Status: REVIEWED

      Source sequence(s)
      BC000045
      Consensus CDS
      CCDS14658.1
      UniProtKB/Swiss-Prot
      Q5H915, Q99990
      Related
      ENSP00000359668.3, ENST00000370634.8
      Conserved Domains (1) summary
      pfam07545
      Location:2151
      Vg_Tdu; Vestigial/Tondu family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      136532215..136556799
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      134840972..134865547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)