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    Lgals9 lectin, galactose binding, soluble 9 [ Mus musculus (house mouse) ]

    Gene ID: 16859, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lgals9provided by MGI
    Official Full Name
    lectin, galactose binding, soluble 9provided by MGI
    Primary source
    MGI:MGI:109496
    See related
    Ensembl:ENSMUSG00000001123 AllianceGenome:MGI:109496
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    gal-9; Lgals5; LGALS35; galectin-9
    Summary
    Enables several functions, including carbohydrate binding activity; galactoside binding activity; and protein serine/threonine kinase activator activity. Involved in several processes, including regulation of cytokine production; regulation of defense response; and regulation of leukocyte activation. Located in cytoplasm and nucleus. Is expressed in several structures, including cardiovascular system; hemolymphoid system; intestine; liver; and metanephros. Orthologous to several human genes including LGALS9 (galectin 9) and LGALS9B (galectin 9B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver adult (RPKM 359.2), large intestine adult (RPKM 344.6) and 18 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lgals9 in Genome Data Viewer
    Location:
    11 B5; 11 46.74 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78853805..78875750, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78962979..78984924, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19741 Neighboring gene STARR-seq mESC enhancer starr_30104 Neighboring gene Nos2 promoter region Neighboring gene nitric oxide synthase 2, inducible Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:78787018-78787219 Neighboring gene STARR-seq mESC enhancer starr_30105 Neighboring gene STARR-seq mESC enhancer starr_30106 Neighboring gene STARR-positive B cell enhancer ABC_E5251 Neighboring gene predicted gene 11201 Neighboring gene kinase suppressor of ras 1 Neighboring gene STARR-seq mESC enhancer starr_30109 Neighboring gene STARR-positive B cell enhancer ABC_E5252 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:78955902-78956103 Neighboring gene STARR-positive B cell enhancer ABC_E10696 Neighboring gene predicted gene, 30413

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables carbohydrate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables carbohydrate binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables carbohydrate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables disaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables galactoside binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables galactoside binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables galactoside binding ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine/threonine kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in female pregnancy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    involved_in immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in maintenance of protein location IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of natural killer cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of natural killer cell degranulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of type II interferon production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of type II interferon production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of type II interferon production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of SMAD protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of T cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of chemokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-1 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-10 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of macrophage activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of regulatory T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in receptor clustering IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT involved_in regulation of T cell chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT involved_in regulation of T cell differentiation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in regulation of T-helper 17 type immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of natural killer cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    galectin-9
    Names
    lectin, galactose binding, soluble 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159301.1NP_001152773.1  galectin-9 isoform 2

      See identical proteins and their annotated locations for NP_001152773.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. This difference results in a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AK146044, CA546274
      Consensus CDS
      CCDS48858.1
      UniProtKB/TrEMBL
      B1AQR8
      Related
      ENSMUSP00000103903.4, ENSMUST00000108268.10
      Conserved Domains (2) summary
      smart00908
      Location:199321
      Gal-bind_lectin; Galactoside-binding lectin
      cd00070
      Location:16145
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
    2. NM_010708.2NP_034838.2  galectin-9 isoform 1

      See identical proteins and their annotated locations for NP_034838.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK146044, CA458877, CA546274
      Consensus CDS
      CCDS25116.1
      UniProtKB/Swiss-Prot
      O08572, O08573, Q3UKE5, Q99L83
      UniProtKB/TrEMBL
      B1AQR8, G3X9T7
      Related
      ENSMUSP00000103904.4, ENSMUST00000108269.10
      Conserved Domains (2) summary
      smart00908
      Location:230352
      Gal-bind_lectin; Galactoside-binding lectin
      cd00070
      Location:16145
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      78853805..78875750 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)