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    Oxr1 oxidation resistance 1 [ Mus musculus (house mouse) ]

    Gene ID: 170719, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Oxr1provided by MGI
    Official Full Name
    oxidation resistance 1provided by MGI
    Primary source
    MGI:MGI:2179326
    See related
    Ensembl:ENSMUSG00000022307 AllianceGenome:MGI:2179326
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C7; C7B; 2210416C20Rik
    Summary
    Enables oxidoreductase activity. Acts upstream of or within several processes, including adult walking behavior; negative regulation of cellular response to oxidative stress; and negative regulation of peptidyl-cysteine S-nitrosylation. Located in nucleolus. Is expressed in several structures, including central nervous system; genitourinary system; liver; lung; and spleen. Human ortholog(s) of this gene implicated in cerebellar hyplasia/atrophy, epilepsy, and global developmental delay. Orthologous to human OXR1 (oxidation resistance 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 11.8), cerebellum adult (RPKM 10.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Oxr1 in Genome Data Viewer
    Location:
    15 B3.1; 15 16.06 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (41310745..41724447)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (41447482..41861051)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38518 Neighboring gene STARR-seq mESC enhancer starr_38519 Neighboring gene predicted gene, 33557 Neighboring gene STARR-seq mESC enhancer starr_38520 Neighboring gene predicted gene, 41312 Neighboring gene STARR-seq mESC enhancer starr_38522 Neighboring gene STARR-seq mESC enhancer starr_38523 Neighboring gene STARR-seq mESC enhancer starr_38524 Neighboring gene STARR-seq mESC enhancer starr_38525 Neighboring gene STARR-seq mESC enhancer starr_38527 Neighboring gene STARR-seq mESC enhancer starr_38528 Neighboring gene STARR-positive B cell enhancer ABC_E10851 Neighboring gene STARR-seq mESC enhancer starr_38530 Neighboring gene STARR-seq mESC enhancer starr_38531 Neighboring gene STARR-seq mESC enhancer starr_38533 Neighboring gene predicted gene, 26854 Neighboring gene STARR-positive B cell enhancer mm9_chr15:41650297-41650598 Neighboring gene STARR-positive B cell enhancer ABC_E7365 Neighboring gene STARR-seq mESC enhancer starr_38536 Neighboring gene STARR-seq mESC enhancer starr_38537 Neighboring gene actin-binding Rho activating protein Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Oxidation Resistance 1 Modulates Glycolytic Pathways in the Cerebellum via an Interaction with Glucose-6-Phosphate Isomerase. Finelli MJ, et al. Mol Neurobiol, 2019 Mar. PMID 29905912, Free PMC Article
    2. Oxidation resistance 1 regulates post-translational modifications of peroxiredoxin 2 in the cerebellum. Svistunova DM, et al. Free Radic Biol Med, 2019 Jan. PMID 30389497, Free PMC Article
    3. Expression and role of the early-response gene Oxr1 in the hyperoxia-challenged mouse retina. Natoli R, et al. Invest Ophthalmol Vis Sci, 2008 Oct. PMID 18539939
    4. Oxr1 is essential for protection against oxidative stress-induced neurodegeneration. Oliver PL, et al. PLoS Genet, 2011 Oct. PMID 22028674, Free PMC Article
    5. The antioxidant protein Oxr1 influences aspects of mitochondrial morphology. Wu Y, et al. Free Radic Biol Med, 2016 Jun. PMID 27036366, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Oxidative Stress Resistance 1 Gene Therapy Retards Neurodegeneration in the rd1 Mutant Mouse Model of Retinopathy.
      Title: Oxidative Stress Resistance 1 Gene Therapy Retards Neurodegeneration in the rd1 Mutant Mouse Model of Retinopathy.
    2. Serum secreted miR-137-containing exosomes affects oxidative stress of neurons by regulating OXR1 in Parkinson's disease.
      Title: Serum secreted miR-137-containing exosomes affects oxidative stress of neurons by regulating OXR1 in Parkinson's disease.
    3. this study shows that Oxr1 regulates post-translational modifications of peroxiredoxin 2 in the cerebellum
      Title: Oxidation resistance 1 regulates post-translational modifications of peroxiredoxin 2 in the cerebellum.
    4. we present a dysregulation of metabolites of glucose metabolism at the pre-symptomatic stage in the Oxr1 knockout cerebellum. We then demonstrate that Oxr1 and Gpi1 physically and functionally interact and that the level of Gpi1 oligomerisation is disrupted when Oxr1 is deleted in vivo. Furthermore, we show that Oxr1 modulates the additional and less well-understood roles of Gpi1 as a cytokine and neuroprotective factor.
      Title: Oxidation Resistance 1 Modulates Glycolytic Pathways in the Cerebellum via an Interaction with Glucose-6-Phosphate Isomerase.
    5. screening a panel of proteins that regulate mitochondrial morphology in bella GCs revealed de-regulation of phospho-Drp1(Ser616), a key mitochondrial fission regulatory factor. Our data provide new insights into the function of Oxr1, revealing that specific isoforms of this novel antioxidant protein are associated with mitochondria.
      Title: The antioxidant protein Oxr1 influences aspects of mitochondrial morphology.
    6. identify OXR1 as the first neuron-specific antioxidant modulator of pathogenesis and disease progression in SOD1-mediated amyotrophic lateral sclerosis
      Title: Neuron-specific antioxidant OXR1 extends survival of a mouse model of amyotrophic lateral sclerosis.
    7. up-regulation of Oxr1 in both human and pre-symptomatic mouse models of amyotrophic lateral sclerosis, indicating that Oxr1 is potentially a novel neuroprotective factor in neurodegenerative disease
      Title: Oxr1 is essential for protection against oxidative stress-induced neurodegeneration.
    8. The patterns of Oxr1 expression observed suggest that the gene is associated with resistance to hyperoxic challenge and that it acts at the level of the outer segment.
      Title: Expression and role of the early-response gene Oxr1 in the hyperoxia-challenged mouse retina.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (2) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC103081, MGC107466

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adult walking behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to hydroperoxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cellular response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of peptidyl-cysteine S-nitrosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    oxidation resistance protein 1
    Names
    nucleolar protein C7
    protein C7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130163.1 → NP_001123635.1  oxidation resistance protein 1 isoform B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region and 5' UTR, compared to variant 5, resulting in a protein (isoform B) with a shorter, distinct N-terminus and a missing region in the C-terminus, compared to isoform E.
      Source sequence(s)
      AC129212, AF324899, AF333985, AK158703
      Consensus CDS
      CCDS49600.1
      UniProtKB/Swiss-Prot
      Q4KMM3
      Related
      ENSMUSP00000087553.6, ENSMUST00000090095.13
      Conserved Domains (3) summary
      smart00584
      Location:589 → 751
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:12 → 54
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:12 → 54
      LysM; LysM domain

    2. NM_001130164.1 → NP_001123636.1  oxidation resistance protein 1 isoform C

      See identical proteins and their annotated locations for NP_001123636.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region and 5' UTR, compared to variant 5, resulting in a protein (isoform C) with a shorter, distinct N-terminus and a missing region in the C-terminus, compared to isoform E.
      Source sequence(s)
      AF333985, AK158703, AW106090, BK006239
      Consensus CDS
      CCDS49601.1
      UniProtKB/TrEMBL
      B1H3M0
      Related
      ENSMUSP00000130456.2, ENSMUST00000166917.3
      Conserved Domains (1) summary
      smart00584
      Location:54 → 216
      TLDc; domain in TBC and LysM domain containing proteins

    3. NM_001130165.2 → NP_001123637.1  oxidation resistance protein 1 isoform D

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences in the coding region and 5' UTR, compared to variant 5, resulting in a protein (isoform D) with a shorter, distinct N-terminus and a missing region in the C-terminus, compared to isoform E.
      Source sequence(s)
      AC129212
      Consensus CDS
      CCDS49599.1
      UniProtKB/TrEMBL
      E9Q0A7
      Related
      ENSMUSP00000126266.2, ENSMUST00000170127.9
      Conserved Domains (3) summary
      smart00584
      Location:670 → 832
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:52 → 135
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:93 → 135
      LysM; LysM domain

    4. NM_001130166.1 → NP_001123638.1  oxidation resistance protein 1 isoform E

      See identical proteins and their annotated locations for NP_001123638.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) encodes the longest isoform (E). Variants 5 and 7 encode the same protein.
      Source sequence(s)
      AF333985, AK158703, BE988908
      Consensus CDS
      CCDS49598.1
      UniProtKB/Swiss-Prot
      Q4KMM3, Q5FWW1, Q99L06, Q99MK1, Q99MP4
      Related
      ENSMUSP00000105926.3, ENSMUST00000110297.10
      Conserved Domains (3) summary
      smart00584
      Location:704 → 866
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:100 → 142
      LysM; LysM domain
      cl26761
      Location:265 → 549
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    5. NM_001358976.1 → NP_001345905.1  oxidation resistance protein 1 isoform F

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 5. The encoded isoform (F) has a distinct N-terminus and is shorter than isoform E.
      Source sequence(s)
      AC129212
      Conserved Domains (3) summary
      smart00584
      Location:697 → 859
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:93 → 135
      LysM; LysM domain
      pfam09726
      Location:257 → 540
      Macoilin; Transmembrane protein

    6. NM_001358977.1 → NP_001345906.1  oxidation resistance protein 1 isoform E

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 5. Variants 5 and 7 encode the same protein.
      Source sequence(s)
      AC118590, AC129212, AC141481, AC164633
      Consensus CDS
      CCDS49598.1
      UniProtKB/Swiss-Prot
      Q4KMM3, Q5FWW1, Q99L06, Q99MK1, Q99MP4
      Conserved Domains (3) summary
      smart00584
      Location:704 → 866
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:100 → 142
      LysM; LysM domain
      cl26761
      Location:265 → 549
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    7. NM_001358978.1 → NP_001345907.1  oxidation resistance protein 1 isoform G

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) lacks an exon in the coding region, compared to variant 1. The encoded isoform (G) is shorter, compared to isoform E.
      Source sequence(s)
      AC118590, AC129212, AC141481, AC164633
      Consensus CDS
      CCDS88760.1
      Related
      ENSMUSP00000155237.2, ENSMUST00000230203.2
      Conserved Domains (3) summary
      smart00584
      Location:677 → 839
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:100 → 142
      LysM; LysM domain
      cl26761
      Location:265 → 549
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    8. NM_130885.2 → NP_570955.1  oxidation resistance protein 1 isoform A

      See identical proteins and their annotated locations for NP_570955.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) has multiple differences in the coding region and 5' UTR, compared to variant 5, resulting in a protein (isoform A) with a shorter and distinct N-terminus, compared to isoform E.
      Source sequence(s)
      AC129212
      Consensus CDS
      CCDS27448.1
      UniProtKB/Swiss-Prot
      Q4KMM3
      Related
      ENSMUSP00000022918.8, ENSMUST00000022918.15
      Conserved Domains (3) summary
      smart00584
      Location:616 → 778
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:12 → 54
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:12 → 54
      LysM; LysM domain

    RNA

    1. NR_152565.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) contains an alternate internal exon, compared to variant 5. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC118590, AC129212, AC141481, AC164633

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      41310745..41724447
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159205.1 → XP_036015098.1  oxidation resistance protein 1 isoform X2

      Conserved Domains (3) summary
      smart00584
      Location:690 → 852
      TLDc; domain in TBC and LysM domain containing proteins
      COG5271
      Location:278 → 562
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam01476
      Location:113 → 155
      LysM; LysM domain

    2. XM_030248362.2 → XP_030104222.1  oxidation resistance protein 1 isoform X4

      Conserved Domains (3) summary
      smart00584
      Location:635 → 797
      TLDc; domain in TBC and LysM domain containing proteins
      COG5271
      Location:196 → 480
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam01476
      Location:31 → 73
      LysM; LysM domain

    3. XM_036159206.1 → XP_036015099.1  oxidation resistance protein 1 isoform X4

      Conserved Domains (3) summary
      smart00584
      Location:635 → 797
      TLDc; domain in TBC and LysM domain containing proteins
      COG5271
      Location:196 → 480
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam01476
      Location:31 → 73
      LysM; LysM domain

    4. XM_036159204.1 → XP_036015097.1  oxidation resistance protein 1 isoform X1

      Conserved Domains (3) summary
      smart00584
      Location:717 → 879
      TLDc; domain in TBC and LysM domain containing proteins
      COG5271
      Location:278 → 562
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam01476
      Location:113 → 155
      LysM; LysM domain

    5. XM_036159207.1 → XP_036015100.1  oxidation resistance protein 1 isoform X5

      Conserved Domains (3) summary
      smart00584
      Location:608 → 770
      TLDc; domain in TBC and LysM domain containing proteins
      COG5271
      Location:196 → 480
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam01476
      Location:31 → 73
      LysM; LysM domain

    6. XM_036159209.1 → XP_036015102.1  oxidation resistance protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A2R8W6N3
      Related
      ENSMUSP00000155161.2, ENSMUST00000230778.2
      Conserved Domains (2) summary
      COG5271
      Location:278 → 562
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam01476
      Location:113 → 155
      LysM; LysM domain

    7. XM_006520526.5 → XP_006520589.1  oxidation resistance protein 1 isoform X3

      Conserved Domains (3) summary
      smart00584
      Location:637 → 799
      TLDc; domain in TBC and LysM domain containing proteins
      COG5271
      Location:198 → 482
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam01476
      Location:33 → 75
      LysM; LysM domain

    8. XM_006520531.3 → XP_006520594.1  oxidation resistance protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A2R8VHT3
      Related
      ENSMUSP00000155424.2, ENSMUST00000230131.2
      Conserved Domains (1) summary
      smart00584
      Location:81 → 243
      TLDc; domain in TBC and LysM domain containing proteins

    RNA

    1. XR_004938803.1 RNA Sequence

    2. XR_004938802.1 RNA Sequence

    3. XR_001781499.2 RNA Sequence

    4. XR_004938804.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4KMM3.3 GenPept UniProtKB/Swiss-Prot:Q4KMM3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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