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    N4bp1 NEDD4 binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 80750, updated on 27-Nov-2024

    Summary

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    Official Symbol
    N4bp1provided by MGI
    Official Full Name
    NEDD4 binding protein 1provided by MGI
    Primary source
    MGI:MGI:2136825
    See related
    Ensembl:ENSMUSG00000031652 AllianceGenome:MGI:2136825
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable RNA nuclease activity; mRNA binding activity; and ubiquitin binding activity. Involved in cellular response to UV; negative regulation of macromolecule metabolic process; and regulation of innate immune response. Located in PML body; cytosol; and nucleolus. Orthologous to human N4BP1 (NEDD4 binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in stomach adult (RPKM 8.2), duodenum adult (RPKM 8.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See N4bp1 in Genome Data Viewer
    Location:
    8 C3; 8 42.1 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (87567764..87612489, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (86841136..86885296, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene siah E3 ubiquitin protein ligase 1A Neighboring gene STARR-seq mESC enhancer starr_22187 Neighboring gene predicted gene 10638 Neighboring gene STARR-seq mESC enhancer starr_22189 Neighboring gene predicted gene, 39215 Neighboring gene predicted gene, 33877 Neighboring gene STARR-positive B cell enhancer ABC_E11393 Neighboring gene STARR-seq mESC enhancer starr_22192 Neighboring gene STARR-seq mESC enhancer starr_22193 Neighboring gene ferritin heavy chain, pseudogene 3 Neighboring gene predicted gene, 33391

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. N4BP1 mediates RAM domain-dependent notch signaling turnover during neocortical development. Ma Z, et al. EMBO J, 2023 Nov 15. PMID 37807845, Free PMC Article
    2. The endoribonuclease N4BP1 prevents psoriasis by controlling both keratinocytes proliferation and neutrophil infiltration. Gou C, et al. Cell Death Dis, 2021 May 14. PMID 33990547, Free PMC Article
    3. Global analysis of the mammalian RNA degradome reveals widespread miRNA-dependent and miRNA-independent endonucleolytic cleavage. Bracken CP, et al. Nucleic Acids Res, 2011 Jul. PMID 21427086, Free PMC Article
    4. N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization. Shi H, et al. Nat Commun, 2021 Mar 2. PMID 33654074, Free PMC Article
    5. N4BP1 is a newly identified nucleolar protein that undergoes SUMO-regulated polyubiquitylation and proteasomal turnover at promyelocytic leukemia nuclear bodies. Sharma P, et al. J Cell Sci, 2010 Apr 15. PMID 20233849, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N4BP1 coordinates ubiquitin-dependent crosstalk within the IkappaB kinase family to limit Toll-like receptor signaling and inflammation.
      Title: N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation.
    2. N4BP1 mediates RAM domain-dependent notch signaling turnover during neocortical development.
      Title: N4BP1 mediates RAM domain-dependent notch signaling turnover during neocortical development.
    3. The endoribonuclease N4BP1 prevents psoriasis by controlling both keratinocytes proliferation and neutrophil infiltration.
      Title: The endoribonuclease N4BP1 prevents psoriasis by controlling both keratinocytes proliferation and neutrophil infiltration.
    4. N4BP1 negatively regulates NF-kappaB by binding and inhibiting NEMO oligomerization.
      Title: N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization.
    5. Integration of innate immune signalling by caspase-8 cleavage of N4BP1.
      Title: Integration of innate immune signalling by caspase-8 cleavage of N4BP1.
    6. N4BP1 can be conjugated with SUMO1 and that this abrogates N4BP1 ubiquitylation.
      Title: N4BP1 is a newly identified nucleolar protein that undergoes SUMO-regulated polyubiquitylation and proteasomal turnover at promyelocytic leukemia nuclear bodies.
    7. May have a role in regulating tumor progression and the response of cancer cells to chemotherapy.
      Title: The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC7607

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA nuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA nuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to UV IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral genome replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in PML body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in PML body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NEDD4-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030563.2 → NP_085040.2  NEDD4-binding protein 1

      See identical proteins and their annotated locations for NP_085040.2

      Status: VALIDATED

      Source sequence(s)
      AA444325, AK147522, BC089324, BM951093, CJ134294, CX122841, CX240926
      Consensus CDS
      CCDS52625.1
      UniProtKB/Swiss-Prot
      Q3TCI4, Q3UH87, Q3UY69, Q6A037
      Related
      ENSMUSP00000034074.8, ENSMUST00000034074.8
      Conserved Domains (1) summary
      pfam11977
      Location:614 → 767
      RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      87567764..87612489 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531517.4 → XP_006531580.1  NEDD4-binding protein 1 isoform X3

    2. XM_006531516.4 → XP_006531579.1  NEDD4-binding protein 1 isoform X1

      Conserved Domains (1) summary
      cl20439
      Location:628 → 691
      RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

    3. XM_036154392.1 → XP_036010285.1  NEDD4-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      Q5EBQ4
      Conserved Domains (2) summary
      cd18728
      Location:532 → 658
      PIN_N4BP1-like; PRORP-like PIN domain of NEDD4 binding protein 1 and related proteins
      cl00098
      Location:1 → 56
      KH-I; K homology (KH) RNA-binding domain, type I

    4. XM_036154391.1 → XP_036010284.1  NEDD4-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      Q5EBQ4
      Conserved Domains (2) summary
      cd18728
      Location:532 → 658
      PIN_N4BP1-like; PRORP-like PIN domain of NEDD4 binding protein 1 and related proteins
      cl00098
      Location:1 → 56
      KH-I; K homology (KH) RNA-binding domain, type I

    5. XM_036154393.1 → XP_036010286.1  NEDD4-binding protein 1 isoform X4

      Conserved Domains (1) summary
      cl00098
      Location:1 → 56
      KH-I; K homology (KH) RNA-binding domain, type I

    RNA

    1. XR_004934903.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6A037.2 GenPept UniProtKB/Swiss-Prot:Q6A037

    Gene LinkOut

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