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    Rpl10a ribosomal protein L10A [ Mus musculus (house mouse) ]

    Gene ID: 19896, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rpl10aprovided by MGI
    Official Full Name
    ribosomal protein L10Aprovided by MGI
    Primary source
    MGI:MGI:1343877
    See related
    Ensembl:ENSMUSG00000037805 AllianceGenome:MGI:1343877
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nedd6; CsA-19
    Summary
    Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is active in synapse. Is expressed in several structures, including cerebral cortex; heart; immune system; liver; and lung. Orthologous to human RPL10A (ribosomal protein L10a). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 583.9), CNS E11.5 (RPKM 479.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rpl10a in Genome Data Viewer
    Location:
    17 A3.3; 17 14.65 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28547557..28550007)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28328471..28331033)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene peroxisome proliferator activator receptor delta Neighboring gene RIKEN cDNA 1810013A23 gene Neighboring gene STARR-positive B cell enhancer ABC_E10941 Neighboring gene STARR-positive B cell enhancer ABC_E2476 Neighboring gene Fanconi anemia, complementation group E Neighboring gene TEA domain family member 3 Neighboring gene STARR-seq mESC enhancer starr_42209 Neighboring gene TUB like protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of genes downregulated in the thymus by cyclosporin-A: preliminary characterization of clone CSA-19. Fisicaro N, et al. Mol Immunol, 1995 Jun. PMID 7609734
    2. Development of a new macrophage-specific TRAP mouse (Mac(TRAP)) and definition of the renal macrophage translational signature. Hofmeister A, et al. Sci Rep, 2020 May 5. PMID 32372032, Free PMC Article
    3. Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Kumar S, et al. Biochem Biophys Res Commun, 1992 Jun 30. PMID 1378265
    4. A stem cell roadmap of ribosome heterogeneity reveals a function for RPL10A in mesoderm production. Genuth NR, et al. Nat Commun, 2022 Sep 19. PMID 36123354, Free PMC Article
    5. A male germ-cell-specific ribosome controls male fertility. Li H, et al. Nature, 2022 Dec. PMID 36517592

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A stem cell roadmap of ribosome heterogeneity reveals a function for RPL10A in mesoderm production.
      Title: A stem cell roadmap of ribosome heterogeneity reveals a function for RPL10A in mesoderm production.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translation at postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation at presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    large ribosomal subunit protein uL1
    Names
    60S ribosomal protein L10a
    NEDD-6
    neural precursor cell expressed developmentally down-regulated protein 6
    NP_001344557.1
    NP_035417.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357628.2 → NP_001344557.1  large ribosomal subunit protein uL1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT025652
      UniProtKB/TrEMBL
      Q99JL6
      Related
      ENSMUST00000150103.3
      Conserved Domains (1) summary
      cl00322
      Location:23 → 133
      Ribosomal_L1; Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds ...

    2. NM_011287.3 → NP_035417.2  large ribosomal subunit protein uL1 isoform 1

      See identical proteins and their annotated locations for NP_035417.2

      Status: VALIDATED

      Source sequence(s)
      CT025652
      Consensus CDS
      CCDS28576.1
      UniProtKB/Swiss-Prot
      P53026
      UniProtKB/TrEMBL
      Q3U561, Q5XJF6
      Related
      ENSMUSP00000048469.9, ENSMUST00000042334.16
      Conserved Domains (1) summary
      cl00322
      Location:2 → 217
      Ribosomal_L1; Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      28547557..28550007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53026.3 GenPept UniProtKB/Swiss-Prot:P53026

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