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    Slc22a17 solute carrier family 22 (organic cation transporter), member 17 [ Mus musculus (house mouse) ]

    Gene ID: 59049, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc22a17provided by MGI
    Official Full Name
    solute carrier family 22 (organic cation transporter), member 17provided by MGI
    Primary source
    MGI:MGI:1926225
    See related
    Ensembl:ENSMUSG00000022199 AllianceGenome:MGI:1926225
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BOIT; Boct; 24p3R; 1700094C23Rik
    Summary
    Enables transmembrane signaling receptor activity. Involved in siderophore transport. Predicted to be located in organelle membrane and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human SLC22A17 (solute carrier family 22 member 17). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 137.6), frontal lobe adult (RPKM 136.9) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc22a17 in Genome Data Viewer
    Location:
    14 C3; 14 27.99 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55144184..55154527, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54906727..54913132, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene BCL2-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E754 Neighboring gene poly(A) binding protein, nuclear 1 Neighboring gene embryonal Fyn-associated substrate Neighboring gene STARR-seq mESC enhancer starr_36750 Neighboring gene interleukin 25 Neighboring gene CKLF-like MARVEL transmembrane domain containing 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SLC22A17 as a Cell Death-Linked Regulator of Tight Junctions in Cerebral Ischemia. Li W, et al. Stroke, 2024 Jun. PMID 38738428
    2. Lipocalin-2 (24p3/neutrophil gelatinase-associated lipocalin (NGAL)) receptor is expressed in distal nephron and mediates protein endocytosis. Langelueddecke C, et al. J Biol Chem, 2012 Jan 2. PMID 22084236, Free PMC Article
    3. Tonicity inversely modulates lipocalin-2 (Lcn2/24p3/NGAL) receptor (SLC22A17) and Lcn2 expression via Wnt/β-catenin signaling in renal inner medullary collecting duct cells: implications for cell fate and bacterial infection. Betten R, et al. Cell Commun Signal, 2018 Nov 7. PMID 30404645, Free PMC Article
    4. A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. Devireddy LR, et al. Cell, 2005 Dec 29. PMID 16377569
    5. Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Gurdziel K, et al. Dev Dyn, 2016 May. PMID 26930384, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SLC22A17 as a Cell Death-Linked Regulator of Tight Junctions in Cerebral Ischemia.
      Title: SLC22A17 as a Cell Death-Linked Regulator of Tight Junctions in Cerebral Ischemia.
    2. Lcn2-R upregulation and Lcn2 downregulation via Wnt/beta-catenin may promote adaptive osmotolerant survival of IMCD cells
      Title: Tonicity inversely modulates lipocalin-2 (Lcn2/24p3/NGAL) receptor (SLC22A17) and Lcn2 expression via Wnt/β-catenin signaling in renal inner medullary collecting duct cells: implications for cell fate and bacterial infection.
    3. 24p3R binds proteins filtered by the kidney with high affinity and may contribute to receptor-mediated endocy of proteins
      Title: Lipocalin-2 (24p3/neutrophil gelatinase-associated lipocalin (NGAL)) receptor is expressed in distal nephron and mediates protein endocytosis.
    4. cloning of the lipocalin 24p3 receptor (24p3R). Ectopic 24p3R expression confers on cells the ability to undergo either iron uptake or apoptosis, dependent upon the iron content of the ligand.
      Title: A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in siderophore transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in organelle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in organelle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 22 member 17
    Names
    24p3 receptor
    brain-type organic cation transporter
    lipocalin-2 receptor
    organic cation transporter BOCT

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360406.1 → NP_001347335.1  solute carrier family 22 member 17 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AA271560, AK007059, BY291454, CX206695
      UniProtKB/TrEMBL
      A0A2I3BQL1
      Related
      ENSMUSP00000154165.3, ENSMUST00000228495.3
      Conserved Domains (1) summary
      cd17445
      Location:63 → 476
      MFS_SLC22A17; Solute carrier family 22, member 17 of the Major Facilitator Superfamily

    2. NM_021551.4 → NP_067526.2  solute carrier family 22 member 17 isoform 2

      See identical proteins and their annotated locations for NP_067526.2

      Status: VALIDATED

      Source sequence(s)
      AK007059, BB809257, BY291454
      Consensus CDS
      CCDS36924.1
      UniProtKB/Swiss-Prot
      Q9D9E0, Q9WTM1
      Related
      ENSMUSP00000049676.8, ENSMUST00000050772.10
      Conserved Domains (1) summary
      cl28910
      Location:2 → 357
      MFS; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      55144184..55154527 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247904.2 → XP_030103764.1  solute carrier family 22 member 17 isoform X2

      UniProtKB/Swiss-Prot
      Q9D9E0, Q9WTM1
      Conserved Domains (1) summary
      cl28910
      Location:2 → 357
      MFS; Major Facilitator Superfamily

    2. XM_006519338.5 → XP_006519401.1  solute carrier family 22 member 17 isoform X1

      See identical proteins and their annotated locations for XP_006519401.1

      UniProtKB/TrEMBL
      A0A2I3BQL1
      Related
      ENSMUSP00000154217.3, ENSMUST00000228119.3
      Conserved Domains (1) summary
      cd17445
      Location:63 → 476
      MFS_SLC22A17; Solute carrier family 22, member 17 of the Major Facilitator Superfamily

    RNA

    1. XR_004938424.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D9E0.2 GenPept UniProtKB/Swiss-Prot:Q9D9E0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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