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    Cd70 CD70 antigen [ Mus musculus (house mouse) ]

    Gene ID: 21948, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cd70provided by MGI
    Official Full Name
    CD70 antigenprovided by MGI
    Primary source
    MGI:MGI:1195273
    See related
    Ensembl:ENSMUSG00000019489 AllianceGenome:MGI:1195273
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cd27l; CD27LG; Tnfsf7; Tnlg8a
    Summary
    Enables receptor ligand activity. Involved in T cell proliferation. Is active in plasma membrane. Is expressed in Meckel's cartilage; hip; and skeleton. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome. Orthologous to human CD70 (CD70 molecule). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in thymus adult (RPKM 2.9), cerebellum adult (RPKM 2.7) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cd70 in Genome Data Viewer
    Location:
    17 D; 17 29.69 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57452997..57456777, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (57145997..57149777, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11110 Neighboring gene predicted gene, 46589 Neighboring gene tumor necrosis factor (ligand) superfamily, member 9 Neighboring gene STARR-seq mESC enhancer starr_42920 Neighboring gene predicted gene, 33566 Neighboring gene tumor necrosis factor (ligand) superfamily, member 14 Neighboring gene complement component 3 Neighboring gene microRNA 6978

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor ligand activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in B cell mediated immunity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in B cell mediated immunity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in B cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in CD27 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in CD27 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in T cell mediated immunity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in T cell mediated immunity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adaptive immune memory response involving T cells and B cells ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adaptive immune memory response involving T cells and B cells ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    CD70 antigen
    Names
    CD27 ligand
    CD27-L
    Ki-24 antigen
    tumor necrosis factor ligand 8a
    tumor necrosis factor ligand superfamily member 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011617.2NP_035747.1  CD70 antigen

      See identical proteins and their annotated locations for NP_035747.1

      Status: PROVISIONAL

      Source sequence(s)
      CT025692
      Consensus CDS
      CCDS28927.1
      UniProtKB/Swiss-Prot
      O55237
      UniProtKB/TrEMBL
      Q05A52
      Related
      ENSMUSP00000019633.8, ENSMUST00000019633.8
      Conserved Domains (1) summary
      cd00184
      Location:60191
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      57452997..57456777 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)