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    Mobp myelin-associated oligodendrocytic basic protein [ Mus musculus (house mouse) ]

    Gene ID: 17433, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mobpprovided by MGI
    Official Full Name
    myelin-associated oligodendrocytic basic proteinprovided by MGI
    Primary source
    MGI:MGI:108511
    See related
    Ensembl:ENSMUSG00000032517 AllianceGenome:MGI:108511
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MOBP69; MOBP73; MOBP81; MOBP155; MOBP170
    Summary
    A structural constituent of myelin sheath. Predicted to be involved in central nervous system myelin formation. Located in mitochondrion. Is expressed in central nervous system and eye. Human ortholog(s) of this gene implicated in frontotemporal dementia. Orthologous to human MOBP (myelin associated oligodendrocyte basic protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 138.0), cortex adult (RPKM 97.6) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Mobp in Genome Data Viewer
    Location:
    9 F4; 9 71.41 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (119978740..120010554)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (120149742..120181488)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 62 Neighboring gene ribosomal protein SA Neighboring gene predicted gene 5922 Neighboring gene STARR-seq mESC enhancer starr_25493 Neighboring gene predicted gene, 38642 Neighboring gene predicted gene, 47059

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phenotypic analysis of mice deficient in the major myelin protein MOBP, and evidence for a novel Mobp isoform. Yool D, et al. Glia, 2002 Sep. PMID 12203392
    2. Myelin-associated oligodendrocytic basic protein is essential for normal arrangement of the radial component in central nervous system myelin. Yamamoto Y, et al. Eur J Neurosci, 1999 Mar. PMID 10103078
    3. Splicing pattern, transcript start distribution, and DNA sequence of the mouse gene (Mobp) encoding myelin-associated oligodendrocytic basic protein. McCallion AS, et al. Mol Cell Neurosci, 1999 Apr. PMID 10328883
    4. Characterization of the murine splice variant Mobp155: developmental CNS expression pattern and subcellular localization of epitope-tagged protein. Montague P, et al. Glia, 2005 Apr 1. PMID 15625715
    5. Morphometric analysis of the myelin-associated oligodendrocytic basic protein-deficient mouse reveals a possible role for myelin-associated oligodendrocytic basic protein in regulating axonal diameter. Sadahiro S, et al. Neuroscience, 2000. PMID 10854769

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MOBP synthesis is stimulated by Fyn activity.
      Title: MOBP levels are regulated by Fyn kinase and affect the morphological differentiation of oligodendrocytes.
    2. Mobp is associated with the alcohol-preference genotype in the context of alcohol-preferring, compared to alcohol-avoiding mouse strains.
      Title: Ethanol-responsive genes (Crtam, Zbtb16, and Mobp) located in the alcohol-QTL region of chromosome 9 are associated with alcohol preference in mice.
    3. MOBP-deficient mice develop normally, generate intact compact CNS myelin, and demonstrate no obvious clinical phenotype; absence of MOBP is not simply compensated for by increased expression of the "classic" myelin basic protein (MBP).
      Title: Phenotypic analysis of mice deficient in the major myelin protein MOBP, and evidence for a novel Mobp isoform.
    4. Although the Mobp155 and Mobp170 isoforms encode a common predicted C-terminus they have different expression profiles and their products are targeted to mitochondria and the nucleus, respectively, in transiently transfected Cos7 cells.
      Title: Characterization of the murine splice variant Mobp155: developmental CNS expression pattern and subcellular localization of epitope-tagged protein.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of myelin sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of myelin sheath ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in central nervous system myelin formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in myelin sheath HDA PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myelin-associated oligodendrocyte basic protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039365.3 → NP_001034454.1  myelin-associated oligodendrocyte basic protein isoform b

      See identical proteins and their annotated locations for NP_001034454.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 3' terminal exon compared to variant 1. The resulting protein (isoform b) is longer and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AI839250, AK140055
      Consensus CDS
      CCDS23626.1
      UniProtKB/Swiss-Prot
      O35713, Q792D7, Q792D8, Q9D2P8, Q9JLY4, Q9JLY5, Q9JLY6
      Related
      ENSMUSP00000071084.8, ENSMUST00000068698.15
      Conserved Domains (2) summary
      PTZ00449
      Location:79 → 165
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cl22851
      Location:1 → 68
      PHD_SF; PHD finger superfamily

    2. NM_008614.3 → NP_032640.1  myelin-associated oligodendrocyte basic protein isoform a

      See identical proteins and their annotated locations for NP_032640.1

      Status: VALIDATED

      Source sequence(s)
      AK028057, BX630280
      Consensus CDS
      CCDS40808.1
      UniProtKB/Swiss-Prot
      Q9D2P8
      Related
      ENSMUSP00000091287.2, ENSMUST00000093773.8
      Conserved Domains (1) summary
      cl22851
      Location:1 → 67
      PHD_SF; PHD finger superfamily

    RNA

    1. NR_153958.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK083103, CD776657

    2. NR_153959.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC110091

    3. NR_153960.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC110091

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      119978740..120010554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004935332.1 RNA Sequence

    2. XR_004935333.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001039364.2: Suppressed sequence

      Description
      NM_001039364.2: This RefSeq has been removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D2P8.1 GenPept UniProtKB/Swiss-Prot:Q9D2P8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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