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    Ubac1 ubiquitin associated domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 98766, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ubac1provided by MGI
    Official Full Name
    ubiquitin associated domain containing 1provided by MGI
    Primary source
    MGI:MGI:1920995
    See related
    Ensembl:ENSMUSG00000036352 AllianceGenome:MGI:1920995
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kpc2; GBDR1; Gdbr1; Ubadc1; 1110033G07Rik
    Summary
    Predicted to enable polyubiquitin modification-dependent protein binding activity and proteasome binding activity. Predicted to be involved in protein maturation and protein ubiquitination. Predicted to be located in Golgi apparatus; cytosol; and plasma membrane. Predicted to be part of ubiquitin ligase complex. Is expressed in several structures, including cranial ganglion; dorsal root ganglion; liver lobe; neural tube; and vibrissa. Orthologous to human UBAC1 (UBA domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E14.5 (RPKM 72.0), liver E14 (RPKM 70.3) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ubac1 in Genome Data Viewer
    Location:
    2 A3; 2 18.29 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25886970..25911793, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25996958..26021781, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03968 Neighboring gene potassium channel, subfamily T, member 1 Neighboring gene calmodulin regulated spectrin-associated protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E1002 Neighboring gene STARR-positive B cell enhancer ABC_E3363 Neighboring gene STARR-seq mESC enhancer starr_03972 Neighboring gene STARR-seq mESC enhancer starr_03973 Neighboring gene nucleus accumbens associated 2, BEN and BTB (POZ) domain containing Neighboring gene predicted gene, 54107

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. KPC2 relocalizes HOXA2 to the cytoplasm and decreases its transcriptional activity. Bridoux L, et al. Biochim Biophys Acta, 2015 Oct. PMID 26303204
    2. Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase. Kamura T, et al. Nat Cell Biol, 2004 Dec. PMID 15531880
    3. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. our data support that KPC2 regulates Hoxa2 by promoting its relocation to the cytoplasm.
      Title: KPC2 relocalizes HOXA2 to the cytoplasm and decreases its transcriptional activity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables polyubiquitin modification-dependent protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables proteasome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proteasome binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-associated domain-containing protein 1
    Names
    E3 ubiquitin-protein ligase subunit KPC2
    UBA domain-containing protein 1
    kip1 ubiquitination-promoting complex protein 2
    putative glialblastoma cell differentiation-related

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362681.1 → NP_001349610.1  ubiquitin-associated domain-containing protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL731682, AL845455
      Conserved Domains (2) summary
      cd14303
      Location:195 → 232
      UBA1_KPC2; UBA1 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
      cl21463
      Location:294 → 325
      UBA_like_SF; UBA domain-like superfamily

    2. NM_133835.2 → NP_598596.2  ubiquitin-associated domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_598596.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK157857, AK162577, CX243095
      Consensus CDS
      CCDS15795.1
      UniProtKB/Swiss-Prot
      Q3TZH3, Q8VDI7
      Related
      ENSMUSP00000040220.8, ENSMUST00000036509.14
      Conserved Domains (3) summary
      smart00727
      Location:357 → 396
      STI1; Heat shock chaperonin-binding motif
      cd14303
      Location:195 → 232
      UBA1_KPC2; UBA1 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
      cd14304
      Location:294 → 331
      UBA2_KPC2; UBA2 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      25886970..25911793 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498465.1 → XP_006498528.1  ubiquitin-associated domain-containing protein 1 isoform X1

      Conserved Domains (2) summary
      cd14303
      Location:195 → 232
      UBA1_KPC2; UBA1 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
      cd17066
      Location:9 → 95
      Ubl_KPC2; ubiquitin-like (Ubl) domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins

    2. XM_036162737.1 → XP_036018630.1  ubiquitin-associated domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      F6UMH9
      Conserved Domains (2) summary
      cd14303
      Location:93 → 130
      UBA1_KPC2; UBA1 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
      cl21463
      Location:192 → 223
      UBA_like_SF; UBA domain-like superfamily

    3. XM_030252261.2 → XP_030108121.1  ubiquitin-associated domain-containing protein 1 isoform X3

      Conserved Domains (3) summary
      smart00727
      Location:213 → 252
      STI1; Heat shock chaperonin-binding motif
      cd14303
      Location:51 → 88
      UBA1_KPC2; UBA1 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
      cd14304
      Location:150 → 187
      UBA2_KPC2; UBA2 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins

    4. XM_036162736.1 → XP_036018629.1  ubiquitin-associated domain-containing protein 1 isoform X2

      Conserved Domains (3) summary
      smart00727
      Location:255 → 294
      STI1; Heat shock chaperonin-binding motif
      cd14303
      Location:93 → 130
      UBA1_KPC2; UBA1 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
      cd14304
      Location:192 → 229
      UBA2_KPC2; UBA2 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins

    5. XM_030252260.2 → XP_030108120.1  ubiquitin-associated domain-containing protein 1 isoform X2

      Conserved Domains (3) summary
      smart00727
      Location:255 → 294
      STI1; Heat shock chaperonin-binding motif
      cd14303
      Location:93 → 130
      UBA1_KPC2; UBA1 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
      cd14304
      Location:192 → 229
      UBA2_KPC2; UBA2 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins

    6. XM_030252262.2 → XP_030108122.1  ubiquitin-associated domain-containing protein 1 isoform X3

      Conserved Domains (3) summary
      smart00727
      Location:213 → 252
      STI1; Heat shock chaperonin-binding motif
      cd14303
      Location:51 → 88
      UBA1_KPC2; UBA1 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
      cd14304
      Location:150 → 187
      UBA2_KPC2; UBA2 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins

    RNA

    1. XR_004940785.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VDI7.2 GenPept UniProtKB/Swiss-Prot:Q8VDI7

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