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    Afmid arylformamidase [ Mus musculus (house mouse) ]

    Gene ID: 71562, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Afmidprovided by MGI
    Official Full Name
    arylformamidaseprovided by MGI
    Primary source
    MGI:MGI:2448704
    See related
    Ensembl:ENSMUSG00000017718 AllianceGenome:MGI:2448704
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kf; FKF; KFA; Ammd; formylase; 9030621K19Rik
    Summary
    Predicted to enable arylformamidase activity. Acts upstream of or within tryptophan catabolic process to kynurenine. Located in cytoplasm. Is expressed in genitourinary system; gut; nervous system; and respiratory system. Orthologous to human AFMID (arylformamidase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver adult (RPKM 32.0), kidney adult (RPKM 20.6) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Afmid in Genome Data Viewer
    Location:
    11 E2; 11 82.96 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (117716329..117730734)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (117825503..117839908)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6030468B19 gene Neighboring gene STARR-positive B cell enhancer ABC_E5305 Neighboring gene STARR-positive B cell enhancer ABC_E5306 Neighboring gene synaptogyrin 2 Neighboring gene thymidine kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E11501 Neighboring gene STARR-positive B cell enhancer ABC_E4020 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117693509-117693710 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117693767-117693876 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117710178-117710379 Neighboring gene baculoviral IAP repeat-containing 5 Neighboring gene VISTA enhancer mm780 Neighboring gene transmembrane protein 235

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of arylformamidase with reduced thymidine kinase expression leads to impaired glucose tolerance. Hugill AJ, et al. Biol Open, 2015 Oct 2. PMID 26432886, Free PMC Article
    2. Kynurenine formamidase: determination of primary structure and modeling-based prediction of tertiary structure and catalytic triad. Pabarcus MK, et al. Biochim Biophys Acta, 2002 Apr 29. PMID 12007602
    3. Cloning, expression, and catalytic triad of recombinant arylformamidase. Pabarcus MK, et al. Protein Expr Purif, 2005 Nov. PMID 15935693
    4. Comprehensive analysis of the mouse metabolome based on the transcriptome. Bono H, et al. Genome Res, 2003 Jun. PMID 12819132, Free PMC Article
    5. Monitoring type 2 diabetes from volatile faecal metabolome in Cushing's syndrome and single Afmid mouse models via a longitudinal study. Lourenço C, et al. Sci Rep, 2019 Dec 11. PMID 31827172, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Monitoring type 2 diabetes from volatile faecal metabolome in Cushing's syndrome and single Afmid mouse models via a longitudinal study.
      Title: Monitoring type 2 diabetes from volatile faecal metabolome in Cushing's syndrome and single Afmid mouse models via a longitudinal study.
    2. Arylformamidase function is in eliminating toxic metabolites and to a lesser extent in providing intermediates for other processes.
      Title: Effect of arylformamidase (kynurenine formamidase) gene inactivation in mice on enzymatic activity, kynurenine pathway metabolites and phenotype.
    3. activation from a bidirectional promoter is linked to changes in histone modification
      Title: Alternate activation of two divergently transcribed mouse genes from a bidirectional promoter is linked to changes in histone modification.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables arylformamidase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' NAD biosynthetic process from tryptophan IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tryptophan catabolic process to kynurenine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tryptophan catabolic process to kynurenine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tryptophan catabolic process to kynurenine IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kynurenine formamidase
    Names
    KFase
    N-formylkynurenine formamidase
    formylkynureninase
    probable arylformamidase
    NP_001350087.1
    NP_001350088.1
    NP_001350089.1
    NP_082103.1
    XP_006534310.1
    XP_006534311.1
    XP_006534312.1
    XP_006534313.1
    XP_011247570.1
    XP_030102185.1
    XP_030102186.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363158.1 → NP_001350087.1  kynurenine formamidase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591433
      UniProtKB/TrEMBL
      B1AQL0
      Related
      ENSMUST00000148016.8
      Conserved Domains (1) summary
      COG0657
      Location:5 → 285
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

    2. NM_001363159.1 → NP_001350088.1  kynurenine formamidase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL591433
      UniProtKB/TrEMBL
      B1AQL0
      Related
      ENSMUSP00000119310.2, ENSMUST00000149668.2
      Conserved Domains (1) summary
      COG0657
      Location:55 → 279
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

    3. NM_001363160.1 → NP_001350089.1  kynurenine formamidase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL591433
      Conserved Domains (1) summary
      COG0657
      Location:55 → 260
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

    4. NM_027827.3 → NP_082103.1  kynurenine formamidase isoform 3

      See identical proteins and their annotated locations for NP_082103.1

      Status: VALIDATED

      Source sequence(s)
      AL591433, AY099479, BY780917
      Consensus CDS
      CCDS25693.1
      UniProtKB/Swiss-Prot
      B1AQK9, Q80XP3, Q8K4H1, Q8R1K6
      Related
      ENSMUSP00000073102.7, ENSMUST00000073388.13
      Conserved Domains (2) summary
      pfam12697
      Location:89 → 280
      Abhydrolase_6; Alpha/beta hydrolase family
      cl21494
      Location:89 → 279
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      117716329..117730734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246326.1 → XP_030102186.1  kynurenine formamidase isoform X6

      Conserved Domains (1) summary
      COG0657
      Location:70 → 220
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

    2. XM_006534248.2 → XP_006534311.1  kynurenine formamidase isoform X2

      Conserved Domains (1) summary
      COG0657
      Location:55 → 262
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

    3. XM_006534249.2 → XP_006534312.1  kynurenine formamidase isoform X4

      Conserved Domains (1) summary
      COG0657
      Location:70 → 203
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

    4. XM_006534247.4 → XP_006534310.1  kynurenine formamidase isoform X1

      Conserved Domains (1) summary
      COG0657
      Location:5 → 268
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

    5. XM_030246325.2 → XP_030102185.1  kynurenine formamidase isoform X3

      Conserved Domains (1) summary
      COG0657
      Location:5 → 285
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

    6. XM_006534250.4 → XP_006534313.1  kynurenine formamidase isoform X5

      Conserved Domains (1) summary
      COG0657
      Location:66 → 199
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

    7. XM_011249268.3 → XP_011247570.1  kynurenine formamidase isoform X7

      Conserved Domains (1) summary
      COG0657
      Location:5 → 192
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

    RNA

    1. XR_004937035.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K4H1.1 GenPept UniProtKB/Swiss-Prot:Q8K4H1

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