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    mir-10404-2 mir-10404-2 stem loop [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36786394, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mir-10404-2provided by FlyBase
    Official Full Name
    mir-10404-2 stem loopprovided by FlyBase
    Primary source
    FLYBASE:FBgn0285976
    Locus tag
    Dmel_CR46347
    See related
    miRBase:MI0033427; AllianceGenome:FB:FBgn0285976
    Gene type
    ncRNA
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CR46347; dme-mir-10404; Dmel\CR46347; mir-10404; miR-10404; mir-ITS1
    Summary
    Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in miRNA-mediated post-transcriptional gene silencing and positive regulation of G1/S transition of mitotic cell cycle. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mir-10404-2 in Genome Data Viewer
    Location:
    chromosome: X; Y
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X; Y NW_007931121.1 (70290..70358)

    NW_007931121.1Genomic Context describing neighboring genes Neighboring gene ribosomal RNA primary transcript:CR45846 Neighboring gene 2S ribosomal RNA:CR45840 Neighboring gene ribosomal RNA primary transcript:CR45847 Neighboring gene 18S ribosomal RNA:CR45841 Neighboring gene 5.8S ribosomal RNA:CR45842 Neighboring gene 2S ribosomal RNA:CR45843

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_007931121.1 Chromosome X; Y Reference Release 6 plus ISO1 MT Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Repression of G1/S Transition by Transient Inhibition of miR-10404 Expression in Drosophila Primordial Germ Cells. Morita S, et al. iScience, 2020 Mar 27. PMID 32179474, Free PMC Article
    2. Deep experimental profiling of microRNA diversity, deployment, and evolution across the Drosophila genus. Mohammed J, et al. Genome Res, 2018 Jan. PMID 29233922, Free PMC Article
    3. A deeply conserved, noncanonical miRNA hosted by ribosomal DNA. Chak LL, et al. RNA, 2015 Mar. PMID 25605965, Free PMC Article
    4. Dissection of the microRNA Network Regulating Hedgehog Signaling in Drosophila. He T, et al. Front Cell Dev Biol, 2022. PMID 35573695, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    • mir-10404-2-RA; Dmel\mir-10404-2-RA; CR46347-RA; Dmel\CR46347-RA
    • mir-10404-2-RB; Dmel\mir-10404-2-RB; CR46347-RB; Dmel\CR46347-RB
    • mir-10404-2-RM; Dmel\mir-10404-2-RM; CR46347-RM; Dmel\CR46347-RM

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA base-pairing translational repressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in miRNA-mediated post-transcriptional gene silencing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NW_007931121.1 Reference assembly

      Range
      70290..70358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. NR_156799.1 RNA Sequence

      Status: REVIEWED

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