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    SENP2 SUMO specific peptidase 2 [ Homo sapiens (human) ]

    Gene ID: 59343, updated on 9-Dec-2024

    Summary

    Official Symbol
    SENP2provided by HGNC
    Official Full Name
    SUMO specific peptidase 2provided by HGNC
    Primary source
    HGNC:HGNC:23116
    See related
    Ensembl:ENSG00000163904 MIM:608261; AllianceGenome:HGNC:23116
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AXAM2; SMT3IP2
    Summary
    SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004]
    Expression
    Broad expression in testis (RPKM 37.1), brain (RPKM 13.4) and 24 other tissues See more
    Orthologs
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    Genomic context

    See SENP2 in Genome Data Viewer
    Location:
    3q27.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (185586295..185633551)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (188402099..188449380)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (185304083..185351339)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374254 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14975 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20925 Neighboring gene lipase H Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20926 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:185272617-185273292 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:185280735-185281348 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:185281349-185281962 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185300277-185301176 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:185302322-185302941 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:185302942-185303560 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:185303561-185304179 Neighboring gene ribosomal protein L34 pseudogene 10 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:185359885-185360103 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185363553-185364440 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:185369908-185370106 Neighboring gene insulin like growth factor 2 mRNA binding protein 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:185406257-185407456 Neighboring gene IGF2BP2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:185442702-185443202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185445539-185446390 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185446391-185447242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:185449611-185450110 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14976 Neighboring gene uncharacterized LOC124906313 Neighboring gene Sharpr-MPRA regulatory region 9603 Neighboring gene Sharpr-MPRA regulatory region 5696

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1331, DKFZp762A2316

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SUMO-specific endopeptidase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables SUMO-specific endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables deSUMOylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein destabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein desumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein desumoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein desumoylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein sumoylation TAS
    Traceable Author Statement
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of Wnt signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with PML body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    sentrin-specific protease 2
    Names
    SMT3-specific isopeptidase 2
    SUMO1/sentrin/SMT3 specific peptidase 2
    SUMO1/sentrin/SMT3 specific protease 2
    sentrin (SUMO1) specific peptidase 2
    sentrin/SUMO-specific protease SENP2
    NP_067640.2
    XP_005247747.2
    XP_005247748.1
    XP_054203397.1
    XP_054203398.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021627.3NP_067640.2  sentrin-specific protease 2

      See identical proteins and their annotated locations for NP_067640.2

      Status: VALIDATED

      Source sequence(s)
      AC016961, AF151697, AL834380, BC018020, BC040609
      Consensus CDS
      CCDS33902.1
      UniProtKB/Swiss-Prot
      B4DQ42, Q8IW97, Q96SR2, Q9HC62, Q9P2L5
      UniProtKB/TrEMBL
      B4E2S4
      Related
      ENSP00000296257.5, ENST00000296257.10
      Conserved Domains (1) summary
      COG5160
      Location:384589
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      185586295..185633551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005247690.4XP_005247747.2  sentrin-specific protease 2 isoform X1

      UniProtKB/TrEMBL
      B4E2S4
      Conserved Domains (1) summary
      cl23802
      Location:370540
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    2. XM_005247691.4XP_005247748.1  sentrin-specific protease 2 isoform X2

      UniProtKB/TrEMBL
      B4DKY9
      Conserved Domains (1) summary
      cl23802
      Location:221469
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      188402099..188449380
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347422.1XP_054203397.1  sentrin-specific protease 2 isoform X1

      UniProtKB/TrEMBL
      B4E2S4
    2. XM_054347423.1XP_054203398.1  sentrin-specific protease 2 isoform X2

      UniProtKB/TrEMBL
      B4DKY9