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    POLG DNA polymerase gamma, catalytic subunit [ Gallus gallus (chicken) ]

    Gene ID: 404292, updated on 17-Aug-2024

    Summary

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    Symbol
    POLGprovided by CGNC
    Full Name
    DNA polymerase gamma, catalytic subunitprovided by CGNC
    Primary source
    CGNC:49871
    See related
    Ensembl:ENSGALG00010016150
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See POLG in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 10 NC_052541.1 (12956099..12966120)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 10 NC_052582.1 (12833974..12843992)

    Chromosome 10 - NC_052541.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107054204 Neighboring gene microRNA mir-9b-1 Neighboring gene microRNA mir-9-3 Neighboring gene transfer RNA arginine (anticodon UCG) Neighboring gene Fanconi anemia complementation group I Neighboring gene retinaldehyde binding protein 1 Neighboring gene abhydrolase domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of the human mitochondrial DNA polymerase, DNA polymerase gamma. Ropp PA, et al. Genomics, 1996 Sep 15. PMID 8884268
    2. The base substitution fidelity of eucaryotic DNA polymerases. Mispairing frequencies, site preferences, insertion preferences, and base substitution by dislocation. Kunkel TA, et al. J Biol Chem, 1986 Jan 5. PMID 3941068
    3. The mutational specificity of DNA polymerases-alpha and -gamma during in vitro DNA synthesis. Kunkel TA. J Biol Chem, 1985 Oct 15. PMID 3930505
    4. An expressed sequence tag database of T-cell-enriched activated chicken splenocytes: sequence analysis of 5251 clones. Tirunagaru VG, et al. Genomics, 2000 Jun 1. PMID 10860659
    5. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mismatch repair rates and error analysis for chick DNA pol alpha, beta & gamma
      Title: The base substitution fidelity of eucaryotic DNA polymerases. Mispairing frequencies, site preferences, insertion preferences, and base substitution by dislocation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 3'-5' exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of gamma DNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA polymerase subunit gamma-1
    Names
    mitochondrial DNA polymerase catalytic subunit
    polymerase (DNA directed), gamma
    polymerase (DNA) gamma, catalytic subunit
    NP_001383407.1
    XP_040535808.1
    XP_040562901.1
    XP_046754902.1
    XP_046780574.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001396478.1 → NP_001383407.1  DNA polymerase subunit gamma-1

      Status: VALIDATED

      Source sequence(s)
      AI980182, BU225407, DY453652, HAEK01125976, JAENSK010000245, U60297
      UniProtKB/TrEMBL
      A0A8V0Z1D7
      Related
      ENSGALP00010022444.1, ENSGALT00010038822.1
      Conserved Domains (3) summary
      cd08641
      Location:743 → 1160
      DNA_pol_gammaA; Pol gammaA is a family A polymerase that is responsible for DNA replication and repair in mitochondria
      cl02626
      Location:399 → 441
      DNA_pol_A; Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication
      cl10012
      Location:230 → 265
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      12956099..12966120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046898946.1 → XP_046754902.1  DNA polymerase subunit gamma-1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0Z1D7

    2. XM_040706967.2 → XP_040562901.1  DNA polymerase subunit gamma-1 isoform X2

      Conserved Domains (2) summary
      cl02626
      Location:743 → 1118
      DNA_pol_A; Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication
      cl10012
      Location:230 → 265
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

    RNA

    1. XR_003077115.3 RNA Sequence

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      12833974..12843992
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046924618.1 → XP_046780574.1  DNA polymerase subunit gamma-1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0Z1D7

    2. XM_040679874.2 → XP_040535808.1  DNA polymerase subunit gamma-1 isoform X2

      Conserved Domains (2) summary
      cl02626
      Location:743 → 1118
      DNA_pol_A; Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication
      cl10012
      Location:230 → 265
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

    RNA

    1. XR_005852884.2 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q92076.1 GenPept UniProtKB/Swiss-Prot:Q92076

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    Research Materials