U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    Acaca acetyl-Coenzyme A carboxylase alpha [ Mus musculus (house mouse) ]

    Gene ID: 107476, updated on 27-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Acacaprovided by MGI
    Official Full Name
    acetyl-Coenzyme A carboxylase alphaprovided by MGI
    Primary source
    MGI:MGI:108451
    See related
    Ensembl:ENSMUSG00000020532 AllianceGenome:MGI:108451
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Acac; Acc1; Gm738; A530025K05Rik
    Summary
    Enables acetyl-CoA carboxylase activity. Involved in acetyl-CoA metabolic process; fatty acid biosynthetic process; and protein homotetramerization. Acts upstream of or within several processes, including cellular response to prostaglandin E stimulus; lipid homeostasis; and tissue homeostasis. Located in cytosol. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human ACACA (acetyl-CoA carboxylase alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in mammary gland adult (RPKM 81.6), subcutaneous fat pad adult (RPKM 79.2) and 17 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Acaca in Genome Data Viewer
    Location:
    11 C; 11 51.29 cM
    Exon count:
    60
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (84020461..84292477)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (84129635..84401651)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11769 Neighboring gene synergin, gamma Neighboring gene STARR-positive B cell enhancer mm9_chr11:83845520-83845821 Neighboring gene STARR-seq mESC enhancer starr_30212 Neighboring gene dual specificity phosphatase 14 Neighboring gene transcriptional adaptor 2A Neighboring gene predicted gene 11437 Neighboring gene 60S ribosomal protein L35 pseudogene Neighboring gene STARR-seq mESC enhancer starr_30214 Neighboring gene STARR-positive B cell enhancer mm9_chr11:84077985-84078286 Neighboring gene STARR-seq mESC enhancer starr_30216 Neighboring gene STARR-seq mESC enhancer starr_30218 Neighboring gene STARR-seq mESC enhancer starr_30219 Neighboring gene apoptosis antagonizing transcription factor Neighboring gene STARR-seq mESC enhancer starr_30220 Neighboring gene LIM homeobox protein 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. aP2-Cre-mediated inactivation of acetyl-CoA carboxylase 1 causes growth retardation and reduced lipid accumulation in adipose tissues. Mao J, et al. Proc Natl Acad Sci U S A, 2009 Oct 13. PMID 19805143, Free PMC Article
    2. ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice. Nakajima T, et al. J Exp Med, 2021 Dec 6. PMID 34813654, Free PMC Article
    3. Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass. Cantley J, et al. Diabetologia, 2019 Jan. PMID 30334081, Free PMC Article
    4. Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal. Abu-Elheiga L, et al. Proc Natl Acad Sci U S A, 2005 Aug 23. PMID 16103361, Free PMC Article
    5. Acetyl-CoA carboxylase beta expression mediated by MyoD and muscle regulatory factor 4 is differentially affected by retinoic acid receptor and retinoid X receptor. Kim JY, et al. Exp Mol Med, 2003 Feb 28. PMID 12642900

    See all (126) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ACC1-mediated fatty acid biosynthesis intrinsically controls thymic iNKT cell development.
      Title: ACC1-mediated fatty acid biosynthesis intrinsically controls thymic iNKT cell development.
    2. MiR-24-3p enhances the Treg/Th17 balance to improve cerebral ischemic injury by suppressing acetyl-CoA carboxylase 1 expression.
      Title: MiR-24-3p enhances the Treg/Th17 balance to improve cerebral ischemic injury by suppressing acetyl-CoA carboxylase 1 expression.
    3. ACACA reduces lipid accumulation through dual regulation of lipid metabolism and mitochondrial function via AMPK- PPARalpha- CPT1A axis.
      Title: ACACA reduces lipid accumulation through dual regulation of lipid metabolism and mitochondrial function via AMPK- PPARα- CPT1A axis.
    4. Involvement of ACACA (acetyl-CoA carboxylase alpha) in the lung pre-metastatic niche formation in breast cancer by senescence phenotypic conversion in fibroblasts.
      Title: Involvement of ACACA (acetyl-CoA carboxylase α) in the lung pre-metastatic niche formation in breast cancer by senescence phenotypic conversion in fibroblasts.
    5. Circular RNA ACACA negatively regulated p53-modulated mevalonate pathway to promote colorectal tumorigenesis via regulating miR-193a/b-3p/HDAC3 axis.
      Title: Circular RNA ACACA negatively regulated p53-modulated mevalonate pathway to promote colorectal tumorigenesis via regulating miR-193a/b-3p/HDAC3 axis.
    6. Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion.
      Title: Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion.
    7. ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice.
      Title: ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice.
    8. Stabilization of fatty acid synthesis enzyme acetyl-CoA carboxylase 1 suppresses acute myeloid leukemia development.
      Title: Stabilization of fatty acid synthesis enzyme acetyl-CoA carboxylase 1 suppresses acute myeloid leukemia development.
    9. ACC1 determines memory potential of individual CD4(+) T cells by regulating de novo fatty acid biosynthesis.
      Title: ACC1 determines memory potential of individual CD4(+) T cells by regulating de novo fatty acid biosynthesis.
    10. Inhibition of ACC1 can be a previously unrecognized mechanism that underlies calorie restriction-afforded neuroprotection against cerebral ischemic stroke
      Title: ACC1 (Acetyl Coenzyme A Carboxylase 1) Is a Potential Immune Modulatory Target of Cerebral Ischemic Stroke.
    Submit: New GeneRIF Correction See all GeneRIFs (29)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (8)  1 citation

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetyl-CoA carboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetyl-CoA carboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetyl-CoA carboxylase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables acetyl-CoA carboxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables acetyl-CoA carboxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables biotin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acetyl-CoA metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to prostaglandin E stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in lipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in malonyl-CoA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within tissue homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    acetyl-CoA carboxylase 1
    Names
    ACC-alpha
    acetyl-CoA carboxylase 265
    NP_579938.2
    XP_006532016.1
    XP_006532017.1
    XP_006532018.1
    XP_006532019.1
    XP_011246968.2
    XP_011246969.1
    XP_030101321.1
    XP_030101322.1
    XP_030101323.1
    XP_036012108.1
    XP_036012109.1
    XP_036012110.1
    XP_036012111.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133360.3 → NP_579938.2  acetyl-CoA carboxylase 1

      See identical proteins and their annotated locations for NP_579938.2

      Status: VALIDATED

      Source sequence(s)
      AL596252, AL596447
      Consensus CDS
      CCDS25185.1
      UniProtKB/Swiss-Prot
      A2A6H4, Q5SWU6, Q5SWU7, Q5SWU8, Q5SWU9, Q6JIZ1, Q6PHL9, Q705X8, Q705X9, Q91VC8, Q925C4, Q925C5
      Conserved Domains (5) summary
      COG0439
      Location:117 → 619
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:670 → 817
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00364
      Location:752 → 817
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1668 → 2216
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:819 → 1568
      ACC_central; Acetyl-CoA carboxylase, central region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      84020461..84292477
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248667.2 → XP_011246969.1  acetyl-CoA carboxylase 1 isoform X4

      See identical proteins and their annotated locations for XP_011246969.1

      UniProtKB/Swiss-Prot
      A2A6H4, Q5SWU6, Q5SWU7, Q5SWU8, Q5SWU9, Q6JIZ1, Q6PHL9, Q705X8, Q705X9, Q91VC8, Q925C4, Q925C5
      Conserved Domains (5) summary
      COG0439
      Location:117 → 619
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:670 → 817
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00364
      Location:752 → 817
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1668 → 2216
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:819 → 1568
      ACC_central; Acetyl-CoA carboxylase, central region

    2. XM_030245463.1 → XP_030101323.1  acetyl-CoA carboxylase 1 isoform X5

      Conserved Domains (5) summary
      COG0439
      Location:1 → 450
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:501 → 648
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00364
      Location:583 → 648
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1499 → 2047
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:650 → 1399
      ACC_central; Acetyl-CoA carboxylase, central region

    3. XM_006531953.3 → XP_006532016.1  acetyl-CoA carboxylase 1 isoform X3

      UniProtKB/Swiss-Prot
      Q5SWU9
      Conserved Domains (5) summary
      COG0439
      Location:155 → 657
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:708 → 855
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00364
      Location:791 → 855
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1706 → 2254
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:857 → 1606
      ACC_central; Acetyl-CoA carboxylase, central region

    4. XM_036156216.1 → XP_036012109.1  acetyl-CoA carboxylase 1 isoform X4

      UniProtKB/Swiss-Prot
      A2A6H4, Q5SWU6, Q5SWU7, Q5SWU8, Q5SWU9, Q6JIZ1, Q6PHL9, Q705X8, Q705X9, Q91VC8, Q925C4, Q925C5
      Conserved Domains (5) summary
      COG0439
      Location:117 → 619
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:670 → 817
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00364
      Location:752 → 817
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1668 → 2216
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:819 → 1568
      ACC_central; Acetyl-CoA carboxylase, central region

    5. XM_036156215.1 → XP_036012108.1  acetyl-CoA carboxylase 1 isoform X4

      UniProtKB/Swiss-Prot
      A2A6H4, Q5SWU6, Q5SWU7, Q5SWU8, Q5SWU9, Q6JIZ1, Q6PHL9, Q705X8, Q705X9, Q91VC8, Q925C4, Q925C5
      Conserved Domains (5) summary
      COG0439
      Location:117 → 619
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:670 → 817
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00364
      Location:752 → 817
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1668 → 2216
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:819 → 1568
      ACC_central; Acetyl-CoA carboxylase, central region

    6. XM_006531954.3 → XP_006532017.1  acetyl-CoA carboxylase 1 isoform X4

      See identical proteins and their annotated locations for XP_006532017.1

      UniProtKB/Swiss-Prot
      A2A6H4, Q5SWU6, Q5SWU7, Q5SWU8, Q5SWU9, Q6JIZ1, Q6PHL9, Q705X8, Q705X9, Q91VC8, Q925C4, Q925C5
      Related
      ENSMUSP00000099490.2, ENSMUST00000103201.8
      Conserved Domains (5) summary
      COG0439
      Location:117 → 619
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:670 → 817
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00364
      Location:752 → 817
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1668 → 2216
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:819 → 1568
      ACC_central; Acetyl-CoA carboxylase, central region

    7. XM_006531956.3 → XP_006532019.1  acetyl-CoA carboxylase 1 isoform X4

      See identical proteins and their annotated locations for XP_006532019.1

      UniProtKB/Swiss-Prot
      A2A6H4, Q5SWU6, Q5SWU7, Q5SWU8, Q5SWU9, Q6JIZ1, Q6PHL9, Q705X8, Q705X9, Q91VC8, Q925C4, Q925C5
      Related
      ENSMUSP00000020843.7, ENSMUST00000020843.13
      Conserved Domains (5) summary
      COG0439
      Location:117 → 619
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:670 → 817
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00364
      Location:752 → 817
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1668 → 2216
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:819 → 1568
      ACC_central; Acetyl-CoA carboxylase, central region

    8. XM_036156217.1 → XP_036012110.1  acetyl-CoA carboxylase 1 isoform X5

      Conserved Domains (5) summary
      COG0439
      Location:1 → 450
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:501 → 648
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00364
      Location:583 → 648
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1499 → 2047
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:650 → 1399
      ACC_central; Acetyl-CoA carboxylase, central region

    9. XM_030245461.2 → XP_030101321.1  acetyl-CoA carboxylase 1 isoform X1

      Conserved Domains (5) summary
      COG0439
      Location:195 → 697
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:748 → 895
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00364
      Location:831 → 895
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1746 → 2294
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:897 → 1646
      ACC_central; Acetyl-CoA carboxylase, central region

    10. XM_011248666.3 → XP_011246968.2  acetyl-CoA carboxylase 1 isoform X2

      Conserved Domains (5) summary
      COG0439
      Location:195 → 697
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:748 → 895
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00364
      Location:831 → 895
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1738 → 2286
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:897 → 1638
      ACC_central; Acetyl-CoA carboxylase, central region

    11. XM_006531955.3 → XP_006532018.1  acetyl-CoA carboxylase 1 isoform X4

      See identical proteins and their annotated locations for XP_006532018.1

      UniProtKB/Swiss-Prot
      A2A6H4, Q5SWU6, Q5SWU7, Q5SWU8, Q5SWU9, Q6JIZ1, Q6PHL9, Q705X8, Q705X9, Q91VC8, Q925C4, Q925C5
      Conserved Domains (5) summary
      COG0439
      Location:117 → 619
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:670 → 817
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00364
      Location:752 → 817
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1668 → 2216
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:819 → 1568
      ACC_central; Acetyl-CoA carboxylase, central region

    12. XM_036156218.1 → XP_036012111.1  acetyl-CoA carboxylase 1 isoform X5

      Conserved Domains (5) summary
      COG0439
      Location:1 → 450
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:501 → 648
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00364
      Location:583 → 648
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1499 → 2047
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:650 → 1399
      ACC_central; Acetyl-CoA carboxylase, central region

    13. XM_030245462.2 → XP_030101322.1  acetyl-CoA carboxylase 1 isoform X4

      UniProtKB/Swiss-Prot
      A2A6H4, Q5SWU6, Q5SWU7, Q5SWU8, Q5SWU9, Q6JIZ1, Q6PHL9, Q705X8, Q705X9, Q91VC8, Q925C4, Q925C5
      Conserved Domains (5) summary
      COG0439
      Location:117 → 619
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:670 → 817
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00364
      Location:752 → 817
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1668 → 2216
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:819 → 1568
      ACC_central; Acetyl-CoA carboxylase, central region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SWU9.1 GenPept UniProtKB/Swiss-Prot:Q5SWU9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous