Chordc1 cysteine and histidine rich domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Chordc1provided by MGI
Official Full Name: cysteine and histidine rich domain containing 1provided by MGI
Primary source: MGI:MGI:1914167
See related: Ensembl:ENSMUSG00000001774 AllianceGenome:MGI:1914167
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Chp-1; morgana; 1110001O09Rik
Summary: Enables ADP binding activity; ATP binding activity; and zinc ion binding activity. Involved in several processes, including chaperone-mediated protein folding; negative regulation of Rho-dependent protein serine/threonine kinase activity; and regulation of centrosome duplication. Is expressed in brain; olfactory epithelium; trigeminal ganglion; and vomeronasal organ. Used to study chronic myeloid leukemia. Orthologous to human CHORDC1 (cysteine and histidine rich domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 22.5), placenta adult (RPKM 16.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A2; 9 7.01 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (18203563..18225296)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (18292267..18314000)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Morgana silencing blocks metastasis formation in breast cancer mouse models and this phenotype is reverted by IkappaBalpha downregulation.
Title: The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis.
Loss of Morgana expression is associated with drug resistance and chronic myeloid leukemia.
Title: Morgana acts as an oncosuppressor in chronic myeloid leukemia.
morgana causes PTEN destabilization, by inhibiting ROCK activity
Title: Morgana acts as a proto-oncogene through inhibition of a ROCK-PTEN pathway.
Chp-1 and melusin can interact with cochaperones PP5 and Sgt1 and with each other in an ATP-dependent manner
Title: Dynamic nucleotide-dependent interactions of cysteine- and histidine-rich domain (CHORD)-containing Hsp90 cochaperones Chp-1 and melusin with cochaperones PP5 and Sgt1.
Overexpression of morgana/CHP-1 in NIH3T3 cells leads to the increased stress resistance of the cells.
Title: Morgana/CHP-1 is a novel chaperone able to protect cells from stress.
Morgana/chp-1 downregulation promotes the interaction between ROCK II and nucleophosmin, leading to an increased ROCK II kinase activity, which results in centrosome amplification.
Title: Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis.
Full length sequence, gene structure and expression of Chp-1.
Title: Chp-1 and melusin, two CHORD containing proteins in vertebrates.
results suggest that Chordc1 mRNA is under complex and widespread transcriptional regulation during development and implicate Chordc1 in circadian and/or homeostatic mechanisms in mammalian brain.
Title: The zinc-binding protein chordc1 undergoes complex diurnal changes in mRNA expression during mouse brain development.
The first biochemical evidence demonstrating that mammalian Chp-1 is a novel Hsp90-interacting protein.
Title: Mammalian CHORD-containing protein 1 is a novel heat shock protein 90-interacting protein.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ADP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables Hsp90 protein binding	IEA Inferred from Electronic Annotation more info
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
NOT enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in centrosome duplication	IBA Inferred from Biological aspect of Ancestor more info
involved_in chaperone-mediated protein folding	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of Rho-dependent protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cellular response to heat	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of centrosome duplication	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: cysteine and histidine-rich domain-containing protein 1

Names: CHORD domain-containing protein 1; CHORD-containing protein 1; cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1; protein morgana

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025844.2 → NP_080120.1 cysteine and histidine-rich domain-containing protein 1

See identical proteins and their annotated locations for NP_080120.1

Status: PROVISIONAL

Source sequence(s)

AK003259

Consensus CDS

CCDS22842.1

UniProtKB/Swiss-Prot

Q9CSI5, Q9D1P4

Related

ENSMUSP00000001825.8, ENSMUST00000001825.9

Conserved Domains (2) summary

cd06488
Location:230 → 316

p23_melusin_like; p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related proteins. Melusin's tail domain interacts with the cytoplasmic domain of beta1-A and beta1-D isoforms of beta1 integrin, it does not bind other integrin beta ...

pfam04968
Location:3 → 64

CHORD; CHORD