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    Grina glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) [ Mus musculus (house mouse) ]

    Gene ID: 66168, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Grinaprovided by MGI
    Official Full Name
    glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)provided by MGI
    Primary source
    MGI:MGI:1913418
    See related
    Ensembl:ENSMUSG00000022564 AllianceGenome:MGI:1913418
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lag; Tmbim3; 1110025J15Rik
    Summary
    Enables transmembrane transporter binding activity. Acts upstream of or within endoplasmic reticulum calcium ion homeostasis and negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Located in Golgi apparatus and endoplasmic reticulum. Is expressed in cerebral cortex; genitourinary system; and heart valve. Orthologous to human GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 447.4), kidney adult (RPKM 386.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Grina in Genome Data Viewer
    Location:
    15 D3; 15 35.59 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76130917..76134109)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76246717..76249909)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene plectin Neighboring gene microRNA 1942 Neighboring gene poly (ADP-ribose) polymerase family, member 10 Neighboring gene microRNA 6953 Neighboring gene spermatogenesis and centriole associated 1 Neighboring gene myocardial infraction associated transcript 2 Neighboring gene microRNA 3079

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. EPO and TMBIM3/GRINA Promote the Activation of the Adaptive Arm and Counteract the Terminal Arm of the Unfolded Protein Response after Murine Transient Cerebral Ischemia. Habib P, et al. Int J Mol Sci, 2019 Oct 31. PMID 31683519, Free PMC Article
    2. Mouse transmembrane BAX inhibitor motif 3 (Tmbim3) encodes a 38 kDa transmembrane protein expressed in the central nervous system. Nielsen JA, et al. Mol Cell Biochem, 2011 Nov. PMID 21614515
    3. EPO regulates neuroprotective Transmembrane BAX Inhibitor-1 Motif-containing (TMBIM) family members GRINA and FAIM2 after cerebral ischemia-reperfusion injury. Habib P, et al. Exp Neurol, 2019 Oct. PMID 31211943
    4. TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis. Rojas-Rivera D, et al. Cell Death Differ, 2012 Jun. PMID 22240901, Free PMC Article
    5. Identification of molecules preferentially expressed beneath the marginal zone in the developing cerebral cortex. Tachikawa K, et al. Neurosci Res, 2008 Feb. PMID 18055048

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GRINA/TMBIM3 plays a crucial role in post-ischemic unfolded protein response (UPR).
      Title: EPO and TMBIM3/GRINA Promote the Activation of the Adaptive Arm and Counteract the Terminal Arm of the Unfolded Protein Response after Murine Transient Cerebral Ischemia.
    2. In this study, the authors show that TMBIM3 is expressed in the brain including high levels in the hippocampus.
      Title: Mouse transmembrane BAX inhibitor motif 3 (Tmbim3) encodes a 38 kDa transmembrane protein expressed in the central nervous system.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within endoplasmic reticulum calcium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein lifeguard 1
    Names
    NMDA receptor glutamate-binding subunit
    glutamate [NMDA] receptor-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023168.3 → NP_075657.1  protein lifeguard 1

      See identical proteins and their annotated locations for NP_075657.1

      Status: PROVISIONAL

      Source sequence(s)
      AC110211
      Consensus CDS
      CCDS27563.1
      UniProtKB/Swiss-Prot
      Q8CI25, Q9ESF4
      Related
      ENSMUSP00000023225.7, ENSMUST00000023225.8
      Conserved Domains (2) summary
      cd10428
      Location:128 → 341
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
      pfam15240
      Location:10 → 114
      Pro-rich; Proline-rich

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76130917..76134109
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248690.1 → XP_030104550.1  protein lifeguard 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8CI25, Q9ESF4
      Conserved Domains (2) summary
      cd10428
      Location:128 → 341
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
      pfam15240
      Location:10 → 114
      Pro-rich; Proline-rich

    2. XM_006521250.4 → XP_006521313.1  protein lifeguard 1 isoform X1

      See identical proteins and their annotated locations for XP_006521313.1

      UniProtKB/Swiss-Prot
      Q8CI25, Q9ESF4
      Conserved Domains (2) summary
      cd10428
      Location:128 → 341
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
      pfam15240
      Location:10 → 114
      Pro-rich; Proline-rich

    3. XM_006521251.4 → XP_006521314.1  protein lifeguard 1 isoform X1

      See identical proteins and their annotated locations for XP_006521314.1

      UniProtKB/Swiss-Prot
      Q8CI25, Q9ESF4
      Conserved Domains (2) summary
      cd10428
      Location:128 → 341
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
      pfam15240
      Location:10 → 114
      Pro-rich; Proline-rich

    4. XM_011245709.3 → XP_011244011.1  protein lifeguard 1 isoform X1

      See identical proteins and their annotated locations for XP_011244011.1

      UniProtKB/Swiss-Prot
      Q8CI25, Q9ESF4
      Conserved Domains (2) summary
      cd10428
      Location:128 → 341
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
      pfam15240
      Location:10 → 114
      Pro-rich; Proline-rich

    5. XM_006521249.4 → XP_006521312.1  protein lifeguard 1 isoform X1

      See identical proteins and their annotated locations for XP_006521312.1

      UniProtKB/Swiss-Prot
      Q8CI25, Q9ESF4
      Conserved Domains (2) summary
      cd10428
      Location:128 → 341
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
      pfam15240
      Location:10 → 114
      Pro-rich; Proline-rich
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ESF4.1 GenPept UniProtKB/Swiss-Prot:Q9ESF4

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