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    Dnah8 dynein, axonemal, heavy chain 8 [ Mus musculus (house mouse) ]

    Gene ID: 13417, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dnah8provided by MGI
    Official Full Name
    dynein, axonemal, heavy chain 8provided by MGI
    Primary source
    MGI:MGI:107714
    See related
    Ensembl:ENSMUSG00000033826 AllianceGenome:MGI:107714
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ATPase; Dnahc8; Hst6.7b; P1-Loop
    Summary
    Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement involved in cell motility and outer dynein arm assembly. Predicted to be located in axoneme. Predicted to be part of outer dynein arm. Predicted to be active in sperm flagellum. Is expressed in brain and thymus primordium. Used to study spermatogenic failure 46. Human ortholog(s) of this gene implicated in spermatogenic failure 46. Orthologous to human DNAH8 (dynein axonemal heavy chain 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 24.8) and thymus adult (RPKM 3.7) See more
    Orthologs
    human all
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    Genomic context

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    See Dnah8 in Genome Data Viewer
    Location:
    17 A3.3; 17 15.71 cM
    Exon count:
    94
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (30845909..31094736)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (30626935..30875762)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8666 Neighboring gene RIKEN cDNA 1700097N02 gene Neighboring gene 40S ribosomal protein S13 pseudogene Neighboring gene glyoxalase 1 Neighboring gene predicted gene, 24661 Neighboring gene predicted gene, 41561 Neighboring gene STARR-seq mESC enhancer starr_42315 Neighboring gene glucagon-like peptide 1 receptor Neighboring gene predicted gene, 41562

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Copper Efflux System Required in Murine Lung Infection by Haemophilus influenzae Composed of a Canonical ATPase Gene and Tandem Chaperone Gene Copies. Wong SM, et al. Infect Immun, 2023 May 16. PMID 37014212, Free PMC Article
    2. Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility. Liu C, et al. Am J Hum Genet, 2020 Aug 6. PMID 32619401, Free PMC Article
    3. Whole-exome sequencing study of hypospadias. Chen Z, et al. iScience, 2023 May 19. PMID 37168556, Free PMC Article
    4. The T complex distorter 2 candidate gene, Dnahc8, encodes at least two testis-specific axonemal dynein heavy chains that differ extensively at their amino and carboxyl termini. Samant SA, et al. Dev Biol, 2002 Oct 1. PMID 12297094
    5. [Effects of cocaine on activities of ATPase, LDH and SDH in mouse splenocytes]. Sun WP, et al. Fa Yi Xue Za Zhi, 2010 Apr. PMID 20653129

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Copper Efflux System Required in Murine Lung Infection by Haemophilus influenzae Composed of a Canonical ATPase Gene and Tandem Chaperone Gene Copies.
      Title: Copper Efflux System Required in Murine Lung Infection by Haemophilus influenzae Composed of a Canonical ATPase Gene and Tandem Chaperone Gene Copies.
    2. Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility.
      Title: Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility.
    3. Cocaine could inhibit the activities of ATPase, LDH and SDH in cultured splenocytes.
      Title: [Effects of cocaine on activities of ATPase, LDH and SDH in mouse splenocytes].
    4. The interactions of MAP1B with LIS1 in hippocampal neurons, and the association of LIS1 with dynein are reported.
      Title: Binding of microtubule-associated protein 1B to LIS1 affects the interaction between dynein and LIS1.
    5. major isoform of DNAHC8 is copiously expressed, carries an extended N-terminus and full-length C-terminus, and is stable and equally abundant in both testis and sperm from +/+ and t/t animals
      Title: The mouse t complex distorter/sterility candidate, Dnahc8, expresses a gamma-type axonemal dynein heavy chain isoform confined to the principal piece of the sperm tail.
    6. Lis1 does not interact with all dynein complexes found in the brain.
      Title: Regulation of cytoplasmic dynein ATPase by Lis1.
    7. T complex distorter 2 candidate gene, Dnahc8, encodes at least two testis-specific axonemal dynein heavy chains that differ extensively at their amino and carboxyl termini
      Title: The T complex distorter 2 candidate gene, Dnahc8, encodes at least two testis-specific axonemal dynein heavy chains that differ extensively at their amino and carboxyl termini.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables minus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables minus-end-directed microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in outer dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axoneme ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of outer dynein arm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of outer dynein arm ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in sperm flagellum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    dynein axonemal heavy chain 8
    Names
    axonemal beta dynein heavy chain 8
    axonemal dynein heavy chain 8 Dnahc8
    ciliary dynein heavy chain 8
    dynein heavy chain 8, axonemal
    dynein, axon, heavy chain 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013811.4 → NP_038839.2  dynein axonemal heavy chain 8

      See identical proteins and their annotated locations for NP_038839.2

      Status: VALIDATED

      Source sequence(s)
      AC165951, AC165962, AC166166, AC174471
      Consensus CDS
      CCDS37541.1
      UniProtKB/Swiss-Prot
      E9Q010, O08830, Q3V0D2, Q91V63, Q91XP8, Q91XP9, Q91XQ0, Q99MH8, Q9QY72
      Related
      ENSMUSP00000157469.2, ENSMUST00000236140.2
      Conserved Domains (6) summary
      COG5245
      Location:1358 → 4379
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:382 → 936
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1509 → 1914
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:2049 → 2376
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:3031 → 3293
      AAA_8; P-loop containing dynein motor region D4
      pfam18199
      Location:4433 → 4728
      Dynein_C; Dynein heavy chain C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      30845909..31094736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160293.1 → XP_036016186.1  dynein axonemal heavy chain 8 isoform X1

      Conserved Domains (4) summary
      COG5245
      Location:1391 → 4412
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:382 → 969
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam12774
      Location:2082 → 2409
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:4466 → 4761
      Dynein_C; Dynein heavy chain C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91XQ0.2 GenPept UniProtKB/Swiss-Prot:Q91XQ0

    Gene LinkOut

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