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    CDK11A cyclin dependent kinase 11A [ Homo sapiens (human) ]

    Gene ID: 728642, updated on 10-Dec-2024

    Summary

    Official Symbol
    CDK11Aprovided by HGNC
    Official Full Name
    cyclin dependent kinase 11Aprovided by HGNC
    Primary source
    HGNC:HGNC:1730
    See related
    Ensembl:ENSG00000008128 MIM:116951; AllianceGenome:HGNC:1730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDC2L2; CDC2L3; p58GTA; PITSLRE; CDK11-p46; CDK11-p58; CDK11-p110
    Summary
    This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in bone marrow (RPKM 22.4), small intestine (RPKM 18.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CDK11A in Genome Data Viewer
    Location:
    1p36.33
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1702379..1724357, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (1136811..1158725, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1633818..1655796, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member E2B Neighboring gene ribosomal protein S7 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 31 Neighboring gene Sharpr-MPRA regulatory region 10763 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:1618619-1618776 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1619919-1620419 Neighboring gene Sharpr-MPRA regulatory region 15043 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 88 Neighboring gene matrix metallopeptidase 23A (pseudogene) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 32 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1655889-1656728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1660738-1661238 Neighboring gene solute carrier family 35 member E2A (pseudogene) Neighboring gene ribosomal protein S7 pseudogene Neighboring gene uncharacterized LOC112268218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 89 Neighboring gene NAD kinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ55257, FLJ56415, FLJ56557, MGC131975

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of RNA splicing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cell growth IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in regulation of centrosome cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of mRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cyclin-dependent kinase 11A
    Names
    PITSLRE B
    PITSLRE serine/threonine-protein kinase CDC2L2
    cell division cycle 2-like 2 (PITSLRE proteins)
    cell division cycle 2-like protein kinase 2
    cell division protein kinase 11A
    galactosyltransferase-associated protein kinase p58/GTA
    NP_001300825.1
    NP_001300911.1
    NP_076916.2
    NP_277071.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029414.1 RefSeqGene

      Range
      4996..26974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001313896.2NP_001300825.1  cyclin-dependent kinase 11A isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the central coding region compared to variant 1. The encoded isoform (5) is longer than isoform 1.
      Source sequence(s)
      AF067522, AL031282, BC073855
      Consensus CDS
      CCDS81253.1
      UniProtKB/Swiss-Prot
      O95227, O95228, O96012, Q12821, Q12853, Q12854, Q2TAJ0, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ88, Q9UQ89
      UniProtKB/TrEMBL
      B4E3D9
      Related
      ENSP00000367900.1, ENST00000378633.5
      Conserved Domains (2) summary
      cd07843
      Location:420711
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:423713
      PLN00009; cyclin-dependent kinase A; Provisional
    2. NM_001313982.2NP_001300911.1  cyclin-dependent kinase 11A isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses two alternate splice sites in 5' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AF067520, AL031282, BC073855
      Consensus CDS
      CCDS81254.1
      UniProtKB/TrEMBL
      B4E3D9, Q5QPR3
      Related
      ENSP00000350403.2, ENST00000357760.6
      Conserved Domains (2) summary
      cd07843
      Location:416707
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:419709
      PLN00009; cyclin-dependent kinase A; Provisional
    3. NM_024011.4NP_076916.2  cyclin-dependent kinase 11A isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform (1).
      Source sequence(s)
      AF067519, AL031282, AL043340, BC073855, BC094827, DC388505
      Consensus CDS
      CCDS44042.1
      UniProtKB/TrEMBL
      B4E3D9
      Related
      ENSP00000384442.3, ENST00000404249.8
      Conserved Domains (2) summary
      cd07843
      Location:417708
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:420710
      PLN00009; cyclin-dependent kinase A; Provisional
    4. NM_033529.4NP_277071.2  cyclin-dependent kinase 11A isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AF067521, AL031282, AL043340, BC073855, BC094827, DC388505
      Consensus CDS
      CCDS44043.1
      UniProtKB/TrEMBL
      B4E3D9
      Related
      ENSP00000351629.5, ENST00000358779.9
      Conserved Domains (2) summary
      cd07843
      Location:407698
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:410700
      PLN00009; cyclin-dependent kinase A; Provisional

    RNA

    1. NR_132739.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF067518, AL031282, BC073855
      Related
      ENST00000460465.5
    2. NR_132740.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses two alternate internal splice sites compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF067523, AL031282, BC073855

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      1702379..1724357 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      1136811..1158725 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_033527.1: Suppressed sequence

      Description
      NM_033527.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    2. NM_033532.1: Suppressed sequence

      Description
      NM_033532.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    3. NM_033534.1: Suppressed sequence

      Description
      NM_033534.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.