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    Arf2 ARF GTPase 2 [ Mus musculus (house mouse) ]

    Gene ID: 11841, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arf2provided by MGI
    Official Full Name
    ARF GTPase 2provided by MGI
    Primary source
    MGI:MGI:99595
    See related
    Ensembl:ENSMUSG00000062421 AllianceGenome:MGI:99595
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to act upstream of or within protein transport. Located in Golgi apparatus. Is expressed in several structures, including adrenal gland; brain; cranium; genitourinary system; and nasal septum. Orthologous to human ARF2P (ADP ribosylation factor 2, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 36.6), CNS E14 (RPKM 29.3) and 22 other tissues See more
    Orthologs
    all
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    Genomic context

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    See Arf2 in Genome Data Viewer
    Location:
    11 E1; 11 67.64 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (103857551..103876176)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (103966725..103985350)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene N-ethylmaleimide sensitive fusion protein Neighboring gene predicted gene, 35365 Neighboring gene STARR-seq mESC enhancer starr_30866 Neighboring gene CDGSH iron-sulfur domain-containing protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_30868 Neighboring gene STARR-seq mESC enhancer starr_30869 Neighboring gene STARR-positive B cell enhancer ABC_E7072 Neighboring gene STARR-positive B cell enhancer ABC_E69 Neighboring gene STARR-seq mESC enhancer starr_30872 Neighboring gene STARR-positive B cell enhancer ABC_E7073 Neighboring gene STARR-positive B cell enhancer mm9_chr11:103862407-103862708 Neighboring gene predicted gene, 35420 Neighboring gene predicted gene, 51921 Neighboring gene predicted gene, 42092

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular mechanism of membrane recruitment of GGA by ARF in lysosomal protein transport. Shiba T, et al. Nat Struct Biol, 2003 May. PMID 12679809
    2. Expression analysis of type I ARF small GTPases ARF1-3 during mouse brain development. Matsuki T, et al. Mol Biol Rep, 2024 Jan 16. PMID 38227057
    3. Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells. Schürmann A, et al. J Biol Chem, 1994 Jun 3. PMID 8195219
    4. Investigations of the genomic region that contains the clf1 mutation, a causal gene in multifactorial cleft lip and palate in mice. Juriloff DM, et al. Birth Defects Res A Clin Mol Teratol, 2005 Feb. PMID 15690355
    5. Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6). Hosaka M, et al. J Biochem, 1996 Oct. PMID 8947846

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression analysis of type I ARF small GTPases ARF1-3 during mouse brain development.
      Title: Expression analysis of type I ARF small GTPases ARF1-3 during mouse brain development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor 2
    NP_001291503.1
    NP_031503.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304574.1 → NP_001291503.1  ADP-ribosylation factor 2

      See identical proteins and their annotated locations for NP_001291503.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK042977, BY129623, BY683617
      Consensus CDS
      CCDS25525.1
      UniProtKB/Swiss-Prot
      Q3TJ37, Q8BSL7, Q91VR9
      Related
      ENSMUSP00000051814.4, ENSMUST00000057921.10
      Conserved Domains (1) summary
      cl40481
      Location:1 → 180
      YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

    2. NM_007477.5 → NP_031503.1  ADP-ribosylation factor 2

      See identical proteins and their annotated locations for NP_031503.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK053123, BY683617
      Consensus CDS
      CCDS25525.1
      UniProtKB/Swiss-Prot
      Q3TJ37, Q8BSL7, Q91VR9
      Related
      ENSMUSP00000102622.3, ENSMUST00000063347.12
      Conserved Domains (1) summary
      cl40481
      Location:1 → 180
      YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      103857551..103876176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BSL7.2 GenPept UniProtKB/Swiss-Prot:Q8BSL7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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