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    mapkapk3.S MAPK activated protein kinase 3 S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 779225, updated on 20-Nov-2024

    Summary

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    Official Symbol
    mapkapk3.S
    Official Full Name
    MAPK activated protein kinase 3 S homeolog
    Primary source
    Xenbase:XB-GENE-866582
    Locus tag
    XELAEV_18025792mg
    See related
    EnsemblRapid:ENSXLAG00005017615 AllianceGenome:Xenbase:XB-GENE-866582
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    mapkapk3; mapkapk3.L
    Summary
    Predicted to enable several functions, including ATP binding activity; calmodulin binding activity; and protein serine/threonine kinase activity. Predicted to act upstream of or within several processes, including intracellular signal transduction; protein phosphorylation; and toll-like receptor signaling pathway. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in patterned macular dystrophy 3. Orthologous to human MAPKAPK3 (MAPK activated protein kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See mapkapk3.S in Genome Data Viewer
    Location:
    chromosome: 4S
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4S NC_054378.1 (106555232..106589502, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4S NC_030731.1 (100136536..100171586, complement)

    Chromosome 4S - NC_054378.1Genomic Context describing neighboring genes Neighboring gene dedicator of cytokinesis 3 S homeolog Neighboring gene speedy protein 1-B-like Neighboring gene uncharacterized LOC121393357 Neighboring gene posterior protein-like Neighboring gene cytokine inducible SH2 containing protein S homeolog Neighboring gene uncharacterized protein C3orf18 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC154360

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MAPK activated protein kinase 3 S homeolog
    Names
    mitogen-activated protein kinase-activated protein kinase 3 L homeolog
    mitogen-activated protein kinase-activated protein kinase 3 S homeolog
    NP_001090316.1
    XP_018115270.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001096847.1 → NP_001090316.1  MAPK activated protein kinase 3 S homeolog

      See identical proteins and their annotated locations for NP_001090316.1

      Status: PROVISIONAL

      Source sequence(s)
      BC123161
      UniProtKB/TrEMBL
      A0A974D2N4, Q0IHG8
      Conserved Domains (1) summary
      cd14172
      Location:31 → 297
      STKc_MAPKAPK3; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 3

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054378.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      106555232..106589502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018259781.2 → XP_018115270.1  MAPK activated protein kinase 3 S homeolog isoform X1

      UniProtKB/TrEMBL
      A0A1L8GHD7, A0A974HMF4
      Related
      ENSXLAP00005051998.1, ENSXLAT00005053160.1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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