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    Zfhx2 zinc finger homeobox 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305888, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfhx2provided by RGD
    Official Full Name
    zinc finger homeobox 2provided by RGD
    Primary source
    RGD:735143
    See related
    EnsemblRapid:ENSRNOG00000025634 AllianceGenome:RGD:735143
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ZFH
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of neuron differentiation; regulation of sensory perception of pain; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within adult behavior. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Marsili syndrome. Orthologous to human ZFHX2 (zinc finger homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 29.6), Spleen (RPKM 12.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfhx2 in Genome Data Viewer
    Location:
    15p13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (32501755..32541720, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (28533155..28565667, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (33719313..33752665, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene neuroguidin Neighboring gene uncharacterized LOC134482119 Neighboring gene thiamine triphosphatase Neighboring gene adaptor related protein complex 1 subunit gamma 2 Neighboring gene junctophilin 4 Neighboring gene dehydrogenase/reductase member 2 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel human pain insensitivity disorder caused by a point mutation in ZFHX2. Habib AM, et al. Brain, 2018 Feb 1. PMID 29253101, Free PMC Article
    2. Behavioral abnormalities observed in Zfhx2-deficient mice. Komine Y, et al. PLoS One, 2012. PMID 23300874, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adult behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger homeobox protein 2
    Names
    retina zinc finger homeodomain protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098803.1 → NP_001092273.1  zinc finger homeobox protein 2

      See identical proteins and their annotated locations for NP_001092273.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      D3ZF41
      Related
      ENSRNOP00000029097.5, ENSRNOT00000034102.7
      Conserved Domains (5) summary
      PHA03247
      Location:2183 → 2296
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:1189 → 1211
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:2439 → 2482
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:2059 → 2112
      Homeobox; Homeobox domain
      pfam13909
      Location:501 → 525
      zf-H2C2_5; C2H2-type zinc-finger domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      32501755..32541720 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274250.1 → XP_063130320.1  zinc finger homeobox protein 2 isoform X1

      UniProtKB/TrEMBL
      D3ZF41

    2. XM_039093294.2 → XP_038949222.1  zinc finger homeobox protein 2 isoform X2

      UniProtKB/TrEMBL
      D3ZF41
      Related
      ENSRNOP00000110051.1, ENSRNOT00000173672.1
      Conserved Domains (5) summary
      PHA03247
      Location:2158 → 2271
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:1164 → 1186
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:2414 → 2457
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:2034 → 2087
      Homeobox; Homeobox domain
      pfam13909
      Location:501 → 525
      zf-H2C2_5; C2H2-type zinc-finger domain

    3. XM_039093293.2 → XP_038949221.1  zinc finger homeobox protein 2 isoform X1

      UniProtKB/TrEMBL
      D3ZF41
      Conserved Domains (5) summary
      PHA03247
      Location:2183 → 2296
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:1189 → 1211
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:2439 → 2482
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:2059 → 2112
      Homeobox; Homeobox domain
      pfam13909
      Location:501 → 525
      zf-H2C2_5; C2H2-type zinc-finger domain

    4. XM_039093295.2 → XP_038949223.1  zinc finger homeobox protein 2 isoform X3

      Conserved Domains (5) summary
      PHA03247
      Location:1384 → 1497
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:390 → 412
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1640 → 1683
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:1260 → 1313
      Homeobox; Homeobox domain
      pfam00096
      Location:959 → 981
      zf-C2H2; Zinc finger, C2H2 type

    5. XM_039093296.2 → XP_038949224.1  zinc finger homeobox protein 2 isoform X4

      Conserved Domains (5) summary
      PHA03247
      Location:1074 → 1187
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:80 → 102
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1330 → 1373
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:950 → 1003
      Homeobox; Homeobox domain
      pfam00096
      Location:649 → 671
      zf-C2H2; Zinc finger, C2H2 type

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_199492.1: Suppressed sequence

      Description
      NM_199492.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Nucleotide Protein Strain
    Heading Accession and Version

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