H2-K1 histocompatibility 2, K1, K region [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: H2-K1provided by MGI
Official Full Name: histocompatibility 2, K1, K regionprovided by MGI
Primary source: MGI:MGI:95904
See related: Ensembl:ENSMUSG00000061232 AllianceGenome:MGI:95904
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: K-f; H-2K; H2-K; H2-D1; H-2K(d)
Summary: Enables peptide antigen binding activity. Acts upstream of or within several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I; and positive regulation of T cell mediated cytotoxicity. Located in external side of plasma membrane. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and retina. Used to study myositis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-A (major histocompatibility complex, class I, A); HLA-B (major histocompatibility complex, class I, B); and HLA-C (major histocompatibility complex, class I, C). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in duodenum adult (RPKM 724.0), mammary gland adult (RPKM 712.4) and 17 other tissues See more
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Genomic context

Location:: 17 B1; 17 17.98 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (34214986..34219316, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (33996012..34000619, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Major histocompatibility class I molecules H2-Kb and H2-Db proteins regulate sculpting of local cortical circuits and in their absence, the excess connectivity can function as a substrate for cortical plasticity throughout life.
Title: Developmental Sculpting of Intracortical Circuits by MHC Class I H2-Db and H2-Kb.
H-2Kb in an unfolded form to a post-endoplasmic reticulum compartment from where they can cycle back to the endoplasmic reticulum.
Title: Adopting the rapamycin trapping assay to track the trafficking of murine MHC class I alleles, H-2K(b).
Because all forms of H-2K(b) are internalized but little beta2m-receptive heavy chain is present at the cell surface, it is likely that beta2m dissociation and recognition of the heavy chain for lysosomal degradation take place in an endocytic compartment.
Title: Dissociation of β2-microglobulin determines the surface quality control of major histocompatibility complex class I molecules.
tissue-specific h-2K(d) transgenic mice may be valuable tools for determining the mode of induction of CD8(+) T-cell responses.
Title: Generation of tissue-specific H-2Kd transgenic mice for the study of K(d)-restricted malaria epitope-specific CD8+ T-cell responses in vivo.
Mice lacking conventional class Ia and class II MHC molecules H2-Kb, H-2Db, and CIITA mediate partial but incomplete virus clearance during acute lymphocytic choriomeningitis virus infection. Clearance is incomplete and chronic infection follows.
Title: An MHC class Ib-restricted CD8+ T cell response to lymphocytic choriomeningitis virus.
Analysis of CD8-positive T lymphocytes responsive to an H-2Kb-restricted immunodominant peptide displays T cell-homing patterns that support surveillance of both upper- and lower respiratory tract tissues by clonally related cells.
Title: Clonally related CD8+ T cells responsible for rapid population of both diffuse nasal-associated lymphoid tissue and lung after respiratory virus infection.
Adult mice exposed to a noninherited maternal antigen accepts permanently H2-Kb-positive heart allografts despite the presence of normal levels of anti-K(b) T cell receptor transgenic T cells.
Title: Transplantation tolerance to a single noninherited MHC class I maternal alloantigen studied in a TCR-transgenic mouse model.
Major histocompatibility class Ib-restricted CD8-positive T cells, in addition to H2-M3-restricted T cells, contribute to antilisterial immunity and may contribute to immune responses against other intracellular bacteria.
Title: Nonconventional CD8+ T cell responses to Listeria infection in mice lacking MHC class Ia and H2-M3.
The interaction of SHIP, 2B4 activating receptor, and the major histocompatibility complex influence the regulation of the natural killer (NK) cell receptor repertoire, cytolytic function, and interferon-gamma production.
Title: SHIP influences signals from CD48 and MHC class I ligands that regulate NK cell homeostasis, effector function, and repertoire formation.
Data imply that a cognate linkage between TLR3 and MHC class I is required for efficient CTL priming to HSV-1.
Title: Cutting edge: priming of CD8 T cell immunity to herpes simplex virus type 1 requires cognate TLR3 expression in vivo.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (17) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

H2-K (e-PCR), detects polymorphism
- UniSTS:238121

H2-K (e-PCR), detects polymorphism
- UniSTS:238122

H2-K1 (e-PCR), detects polymorphism
- UniSTS:463411

D17Mit28 (e-PCR), detects polymorphism
- UniSTS:116649

H2-K1 (e-PCR), detects polymorphism
- UniSTS:525227

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	ISO Inferred from Sequence Orthology more info
enables CD8 receptor binding	ISO Inferred from Sequence Orthology more info
enables MHC class I protein binding	ISO Inferred from Sequence Orthology more info
enables T cell receptor binding	ISO Inferred from Sequence Orthology more info
enables TAP binding	ISO Inferred from Sequence Orthology more info
enables TAP complex binding	ISO Inferred from Sequence Orthology more info
enables TAP1 binding	ISO Inferred from Sequence Orthology more info
enables TAP2 binding	ISO Inferred from Sequence Orthology more info
enables beta-2-microglobulin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables natural killer cell lectin-like receptor binding	ISO Inferred from Sequence Orthology more info
enables peptide antigen binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide antigen binding	IDA Inferred from Direct Assay more info	PubMed
enables peptide antigen binding	ISO Inferred from Sequence Orthology more info
enables peptide binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of T cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent	IDA Inferred from Direct Assay more info	PubMed
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IBA Inferred from Biological aspect of Ancestor more info
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class I	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inner ear development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of T cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi medial cisterna	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
part_of MHC class I peptide loading complex	ISO Inferred from Sequence Orthology more info
part_of MHC class I protein complex	IEA Inferred from Electronic Annotation more info
part_of MHC class I protein complex	ISO Inferred from Sequence Orthology more info
part_of MHC class Ib protein complex	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cis-Golgi network membrane	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum exit site	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in lumenal side of endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle membrane	TAS Traceable Author Statement more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: H-2 class I histocompatibility antigen, K-W28 alpha chain

Names: H-2 class I histocompatibility antigen, K-B alpha chain; H-2 class I histocompatibility antigen, K-D alpha chain; H-2 class I histocompatibility antigen, K-K alpha chain; H-2 class I histocompatibility antigen, K-Q alpha chain; H-2K(B); H-2K(K); H-2K(Q); MHC H2-K transplantation antigen; MHC class I H2-K-b-alpha-2 cell surface glycoprotein; MHC class I antigen; MHC class I heavy chain H2-K; MHC class I heavy chain heavy chain; MHC class I heavy chain maturation peptide; MHC class II antigen D; MHC class II antigen K; class I major histocompatibility antigen H-2Kd; histocompatibility 2, K region, promoter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001892.3 → NP_001001892.2 H-2 class I histocompatibility antigen, K-W28 alpha chain isoform 1 precursor

See identical proteins and their annotated locations for NP_001001892.2

Status: VALIDATED

Source sequence(s)

CR974462

Consensus CDS

CCDS50069.1

UniProtKB/Swiss-Prot

P01901

UniProtKB/TrEMBL

Q3TVI9, Q7JJ15

Related

ENSMUSP00000025181.11, ENSMUST00000025181.18

Conserved Domains (3) summary

cd07698
Location:204 → 296

IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

pfam00129
Location:22 → 200

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

pfam06623
Location:335 → 359

MHC_I_C; MHC_I C-terminus
NM_001347346.2 → NP_001334275.1 H-2 class I histocompatibility antigen, K-W28 alpha chain isoform 2 precursor

Status: VALIDATED

Source sequence(s)

CR974462

Consensus CDS

CCDS84295.1

UniProtKB/TrEMBL

Q3TH01, W5XHY0

Related

ENSMUSP00000134004.2, ENSMUST00000172912.8
NM_001403362.1 → NP_001390291.1 H-2 class I histocompatibility antigen, K-W28 alpha chain isoform 3 precursor

Status: VALIDATED

Source sequence(s)

CR974462
NM_001403363.1 → NP_001390292.1 H-2 class I histocompatibility antigen, K-W28 alpha chain isoform 4 precursor

Status: VALIDATED

Source sequence(s)

CR974462

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

34214986..34219316 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030249505.2 → XP_030105365.1 H-2 class I histocompatibility antigen, K-W28 alpha chain isoform X2

Related

ENSMUST00000114311.11

Conserved Domains (2) summary

cd07698
Location:204 → 296

IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

pfam00129
Location:23 → 200

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
XM_006523678.5 → XP_006523741.1 H-2 class I histocompatibility antigen, K-W28 alpha chain isoform X7

See identical proteins and their annotated locations for XP_006523741.1

UniProtKB/TrEMBL

W5XHY0

Conserved Domains (3) summary

cd07698
Location:224 → 316

IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

pfam00129
Location:43 → 220

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

pfam06623
Location:355 → 377

MHC_I_C; MHC_I C-terminus
XM_006523677.5 → XP_006523740.1 H-2 class I histocompatibility antigen, K-W28 alpha chain isoform X6

See identical proteins and their annotated locations for XP_006523740.1

UniProtKB/TrEMBL

W5XHY0

Conserved Domains (3) summary

cd07698
Location:224 → 316

IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

pfam00129
Location:43 → 220

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

pfam06623
Location:360 → 382

MHC_I_C; MHC_I C-terminus
XM_006523674.5 → XP_006523737.1 H-2 class I histocompatibility antigen, K-W28 alpha chain isoform X3

See identical proteins and their annotated locations for XP_006523737.1

UniProtKB/TrEMBL

Q3TVI9

Conserved Domains (3) summary

cd07698
Location:224 → 316

IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

pfam00129
Location:43 → 220

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

pfam06623
Location:360 → 382

MHC_I_C; MHC_I C-terminus
XM_006523673.5 → XP_006523736.1 H-2 class I histocompatibility antigen, K-W28 alpha chain isoform X1

See identical proteins and their annotated locations for XP_006523736.1

Conserved Domains (2) summary

cd07698
Location:224 → 316

IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

pfam00129
Location:43 → 220

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
XM_017317259.3 → XP_017172748.1 H-2 class I histocompatibility antigen, K-W28 alpha chain isoform X9

UniProtKB/TrEMBL

W5XHY0

Conserved Domains (3) summary

cd07698
Location:204 → 296

IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

pfam00129
Location:23 → 200

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

pfam06623
Location:335 → 357

MHC_I_C; MHC_I C-terminus
XM_017317258.3 → XP_017172747.1 H-2 class I histocompatibility antigen, K-W28 alpha chain isoform X4

UniProtKB/TrEMBL

W5XHY0

Conserved Domains (3) summary

cd07698
Location:224 → 316

IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

pfam00129
Location:43 → 220

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

pfam06623
Location:355 → 377

MHC_I_C; MHC_I C-terminus

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P01901.1	GenPept	UniProtKB/Swiss-Prot:P01901
P01902.1	GenPept	UniProtKB/Swiss-Prot:P01902
P03991.2	GenPept	UniProtKB/Swiss-Prot:P03991
P04223.1	GenPept	UniProtKB/Swiss-Prot:P04223
P14428.1	GenPept	UniProtKB/Swiss-Prot:P14428