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    RPS6KC1 ribosomal protein S6 kinase C1 [ Homo sapiens (human) ]

    Gene ID: 26750, updated on 10-Dec-2024

    Summary

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    Official Symbol
    RPS6KC1provided by HGNC
    Official Full Name
    ribosomal protein S6 kinase C1provided by HGNC
    Primary source
    HGNC:HGNC:10439
    See related
    Ensembl:ENSG00000136643 MIM:617517; AllianceGenome:HGNC:10439
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RSKL1; RPK118; S6PKh1; humS6PKh1; S6K-delta-1
    Summary
    Sphingosine kinase catalyzes the formation of sphingosine 1 phosphate, a lipid cellular messenger. The protein encoded by this gene can bind to sphingosine kinase and to phosphatidylinositol 3-phosphate, suggesting a role in sphingosine 1 phophate signaling. The encoded protein can also bind to peroxiredoxin-3 and may help transport it to mitochondria. [provided by RefSeq, Mar 2017]
    Expression
    Ubiquitous expression in testis (RPKM 12.3), brain (RPKM 7.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RPS6KC1 in Genome Data Viewer
    Location:
    1q32.3
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (213051241..213862735)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (212294330..213102289)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (213224583..213448117)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2521 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:213131647-213132304 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:213132964-213133621 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:213133682-213134182 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:213141040-213141685 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2524 Neighboring gene Sharpr-MPRA regulatory region 1741 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2525 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2526 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:213188046-213188634 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:213188635-213189222 Neighboring gene CRISPRi-validated cis-regulatory element chr1.11646 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1809 Neighboring gene vasohibin 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:213231113-213231272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2528 Neighboring gene angel homolog 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:213325631-213326306 Neighboring gene NANOG hESC enhancer GRCh37_chr1:213349583-213350260 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:213393895-213394085 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:213404976-213405900 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2529 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:213454938-213455452 Neighboring gene VISTA enhancer hs1324 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:213545088-213545614 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:213545615-213546139 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:213572574-213573110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:213573111-213573646 Neighboring gene MPRA-validated peak692 silencer Neighboring gene VISTA enhancer hs204 Neighboring gene ribosomal protein L31 pseudogene 13 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:213680906-213681904 Neighboring gene NANOG hESC enhancer GRCh37_chr1:213685550-213686112 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_3904 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:213843687-213844216 Neighboring gene PROX1 antisense RNA 1 Neighboring gene U2 spliceosomal RNA Neighboring gene long intergenic non-protein coding RNA 538

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning, characterization, and chromosome mapping of RPS6KC1, a novel putative member of the ribosome protein S6 kinase family, to chromosome 12q12-q13.1. Zhang H, et al. Genomics, 1999 Nov 1. PMID 10552933
    2. Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein. Hayashi S, et al. J Biol Chem, 2002 Sep 6. PMID 12077123
    3. RPK118, a PX domain-containing protein, interacts with peroxiredoxin-3 through pseudo-kinase domains. Liu L, et al. Mol Cells, 2005 Feb 28. PMID 15750338
    4. Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human. Leparc GG, et al. Nucleic Acids Res, 2007. PMID 17452356, Free PMC Article
    5. The protein kinase complement of the human genome. Manning G, et al. Science, 2002 Dec 6. PMID 12471243

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identified as a pseudokinase and named RSKL1
      Title: The protein kinase complement of the human genome.
    2. cloning and characterization of RPK118 as a sphingosine kinase-1-binding protein
      Title: Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein.
    3. findings indicate that RPK118 is a PRDX3-binding protein that may be involved in transporting PRDX3 from the cytoplasm to its mitochondrial site of function or to other membrane structures via endosome trafficking.
      Title: RPK118, a PX domain-containing protein, interacts with peroxiredoxin-3 through pseudo-kinase domains.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein S6 kinase delta-1
    Names
    52 kDa ribosomal protein S6 kinase
    SPHK1-binding protein
    ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein
    ribosomal protein S6 kinase, 52kDa, polypeptide 1
    NP_001129610.1
    NP_001274147.1
    NP_001274148.1
    NP_001274149.1
    NP_001274150.1
    NP_001336575.1
    NP_001336576.1
    NP_001336577.1
    NP_001336578.1
    NP_001336579.1
    NP_001336580.1
    NP_001336581.1
    NP_001336582.1
    NP_001336583.1
    NP_001336586.1
    NP_001336587.1
    NP_001336588.1
    NP_001336589.1
    NP_001336590.1
    NP_001336591.1
    NP_001336592.1
    NP_001336593.1
    NP_001336594.1
    NP_001336595.1
    NP_001336596.1
    NP_001336597.1
    NP_001336598.1
    NP_001336599.1
    NP_001336600.1
    NP_001336601.1
    NP_036556.2
    XP_016856513.2
    XP_047273868.1
    XP_047273875.1
    XP_047273889.1
    XP_047273892.1
    XP_047273895.1
    XP_047273896.1
    XP_047273901.1
    XP_047273904.1
    XP_054191956.1
    XP_054191957.1
    XP_054191958.1
    XP_054191959.1
    XP_054191960.1
    XP_054191961.1
    XP_054191962.1
    XP_054191963.1
    XP_054191964.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136138.4 → NP_001129610.1  ribosomal protein S6 kinase delta-1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.
      Source sequence(s)
      AK122921, AL583826, AL645860, DC323473
      Consensus CDS
      CCDS44317.1
      UniProtKB/TrEMBL
      B4DRK0
      Related
      ENSP00000355926.3, ENST00000366959.4
      Conserved Domains (5) summary
      smart00220
      Location:863 → 1044
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd02677
      Location:226 → 300
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:867 → 1044
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl02563
      Location:11 → 116
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl21453
      Location:323 → 409
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001287218.3 → NP_001274147.1  ribosomal protein S6 kinase delta-1 isoform c

      See identical proteins and their annotated locations for NP_001274147.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR, initiates translation at a downstream start codon, and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a. Variants 3, 4, and 15 all encode the same isoform (c).
      Source sequence(s)
      AL583826, AL645860, BC143449, DC323473
      Consensus CDS
      CCDS73029.1
      UniProtKB/TrEMBL
      B4DRK0, F5H7T0
      Related
      ENSP00000483873.1, ENST00000614059.4
      Conserved Domains (3) summary
      cd02677
      Location:57 → 131
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:667 → 844
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl21453
      Location:134 → 209
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001287219.3 → NP_001274148.1  ribosomal protein S6 kinase delta-1 isoform c

      See identical proteins and their annotated locations for NP_001274148.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in its 5' UTR, initiates translation at a downstream start codon, and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a. Variants 3, 4, and 15 all encode the same isoform (c).
      Source sequence(s)
      AK299298, AL512449, AL583826, AL645860, DC323473
      Consensus CDS
      CCDS73029.1
      UniProtKB/TrEMBL
      B4DRK0, F5H7T0
      Related
      ENSP00000442306.1, ENST00000543470.5
      Conserved Domains (3) summary
      cd02677
      Location:57 → 131
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:667 → 844
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl21453
      Location:134 → 209
      PKc_like; Protein Kinases, catalytic domain

    4. NM_001287220.3 → NP_001274149.1  ribosomal protein S6 kinase delta-1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a. Variants 5 and 22-30 all encode the same isoform (d).
      Source sequence(s)
      AL583826, AL645860, BC143473, DC323473
      Consensus CDS
      CCDS73030.1
      UniProtKB/TrEMBL
      A0A087X1U5
      Related
      ENSP00000484471.1, ENST00000615329.4
      Conserved Domains (1) summary
      cd05576
      Location:414 → 591
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    5. NM_001287221.3 → NP_001274150.1  ribosomal protein S6 kinase delta-1 isoform e

      See identical proteins and their annotated locations for NP_001274150.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (e) has a shorter N-terminus, compared to isoform a. Variants 6 and 9-14 all encode the same isoform (e).
      Source sequence(s)
      AL583826, BC143474, DC323473
      Consensus CDS
      CCDS73028.1
      UniProtKB/TrEMBL
      B4DRK0, F6RJM5
      Related
      ENSP00000439282.2, ENST00000543354.5
      Conserved Domains (3) summary
      cd02677
      Location:57 → 131
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:698 → 875
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl21453
      Location:154 → 240
      PKc_like; Protein Kinases, catalytic domain

    6. NM_001349646.2 → NP_001336575.1  ribosomal protein S6 kinase delta-1 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) encodes isoform f.
      Source sequence(s)
      AL512449, AL583826, AL645860
      UniProtKB/TrEMBL
      B4DRK0
      Conserved Domains (4) summary
      cd07287
      Location:11 → 128
      PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins
      cd02677
      Location:238 → 312
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:848 → 1025
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl21453
      Location:315 → 390
      PKc_like; Protein Kinases, catalytic domain

    7. NM_001349647.2 → NP_001336576.1  ribosomal protein S6 kinase delta-1 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) encodes isoform g.
      Source sequence(s)
      AL512449, AL583826, AL645860
      UniProtKB/TrEMBL
      B4DRK0
      Conserved Domains (4) summary
      cd07287
      Location:11 → 128
      PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins
      cd05576
      Location:758 → 935
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl00299
      Location:158 → 191
      MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
      cl21453
      Location:214 → 300
      PKc_like; Protein Kinases, catalytic domain

    8. NM_001349648.2 → NP_001336577.1  ribosomal protein S6 kinase delta-1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 6 and 10-14, encodes isoform e.
      Source sequence(s)
      AL512449, AL583826, AL645860
      Consensus CDS
      CCDS73028.1
      UniProtKB/TrEMBL
      B4DRK0, F6RJM5
      Conserved Domains (3) summary
      cd02677
      Location:57 → 131
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:698 → 875
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl21453
      Location:154 → 240
      PKc_like; Protein Kinases, catalytic domain

    9. NM_001349649.2 → NP_001336578.1  ribosomal protein S6 kinase delta-1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 6, 9, and 11-14, encodes isoform e.
      Source sequence(s)
      AL512449, AL583826, AL645860
      Consensus CDS
      CCDS73028.1
      UniProtKB/TrEMBL
      B4DRK0, F6RJM5
      Conserved Domains (3) summary
      cd02677
      Location:57 → 131
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:698 → 875
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl21453
      Location:154 → 240
      PKc_like; Protein Kinases, catalytic domain

    10. NM_001349650.2 → NP_001336579.1  ribosomal protein S6 kinase delta-1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 6, 9, 10, and 12-14, encodes isoform e.
      Source sequence(s)
      AL512449, AL583826, AL645860
      Consensus CDS
      CCDS73028.1
      UniProtKB/TrEMBL
      B4DRK0, F6RJM5
      Conserved Domains (3) summary
      cd02677
      Location:57 → 131
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:698 → 875
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl21453
      Location:154 → 240
      PKc_like; Protein Kinases, catalytic domain

    11. NM_001349651.2 → NP_001336580.1  ribosomal protein S6 kinase delta-1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 6, 9-11, 13, and 14, encodes isoform e.
      Source sequence(s)
      AL512449, AL583826, AL645860
      Consensus CDS
      CCDS73028.1
      UniProtKB/TrEMBL
      B4DRK0, F6RJM5
      Conserved Domains (3) summary
      cd02677
      Location:57 → 131
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:698 → 875
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl21453
      Location:154 → 240
      PKc_like; Protein Kinases, catalytic domain

    12. NM_001349652.2 → NP_001336581.1  ribosomal protein S6 kinase delta-1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 6, 9-12, and 14, encodes isoform e.
      Source sequence(s)
      AL512449, AL583826, AL645860
      Consensus CDS
      CCDS73028.1
      UniProtKB/TrEMBL
      B4DRK0, F6RJM5
      Conserved Domains (3) summary
      cd02677
      Location:57 → 131
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:698 → 875
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl21453
      Location:154 → 240
      PKc_like; Protein Kinases, catalytic domain

    13. NM_001349653.2 → NP_001336582.1  ribosomal protein S6 kinase delta-1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 6 and 9-13, encodes isoform e.
      Source sequence(s)
      AL512449, AL583826, AL645860
      Consensus CDS
      CCDS73028.1
      UniProtKB/TrEMBL
      B4DRK0, F6RJM5
      Conserved Domains (3) summary
      cd02677
      Location:57 → 131
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:698 → 875
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl21453
      Location:154 → 240
      PKc_like; Protein Kinases, catalytic domain

    14. NM_001349654.2 → NP_001336583.1  ribosomal protein S6 kinase delta-1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variants 3 and 4, encodes isoform c.
      Source sequence(s)
      AL512449, AL583826, AL645860
      Consensus CDS
      CCDS73029.1
      UniProtKB/TrEMBL
      B4DRK0, F5H7T0
      Conserved Domains (3) summary
      cd02677
      Location:57 → 131
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:667 → 844
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl21453
      Location:134 → 209
      PKc_like; Protein Kinases, catalytic domain

    15. NM_001349657.2 → NP_001336586.1  ribosomal protein S6 kinase delta-1 isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variant 17, encodes isoform h.
      Source sequence(s)
      AL512449, AL583826, AL645860
      UniProtKB/TrEMBL
      B4DRK0
      Conserved Domains (2) summary
      cd05576
      Location:582 → 759
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl21453
      Location:38 → 124
      PKc_like; Protein Kinases, catalytic domain

    16. NM_001349658.2 → NP_001336587.1  ribosomal protein S6 kinase delta-1 isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variant 16, encodes isoform h.
      Source sequence(s)
      AL512449, AL583826, AL645860
      UniProtKB/TrEMBL
      B4DRK0
      Conserved Domains (2) summary
      cd05576
      Location:582 → 759
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl21453
      Location:38 → 124
      PKc_like; Protein Kinases, catalytic domain

    17. NM_001349659.2 → NP_001336588.1  ribosomal protein S6 kinase delta-1 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variants 19-21, encodes isoform i.
      Source sequence(s)
      AL512449, AL583826, AL645860
      UniProtKB/TrEMBL
      B4DRK0
      Conserved Domains (2) summary
      cd05576
      Location:527 → 704
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl21453
      Location:1 → 69
      PKc_like; Protein Kinases, catalytic domain

    18. NM_001349660.2 → NP_001336589.1  ribosomal protein S6 kinase delta-1 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variants 18, 20, and 21, encodes isoform i.
      Source sequence(s)
      AL512449, AL583826, AL645860
      UniProtKB/TrEMBL
      B4DRK0
      Conserved Domains (2) summary
      cd05576
      Location:527 → 704
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl21453
      Location:1 → 69
      PKc_like; Protein Kinases, catalytic domain

    19. NM_001349661.2 → NP_001336590.1  ribosomal protein S6 kinase delta-1 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), as well as variants 18, 19, and 21, encodes isoform i.
      Source sequence(s)
      AL512449, AL583826, AL645860
      UniProtKB/TrEMBL
      B4DRK0
      Conserved Domains (2) summary
      cd05576
      Location:527 → 704
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl21453
      Location:1 → 69
      PKc_like; Protein Kinases, catalytic domain

    20. NM_001349662.2 → NP_001336591.1  ribosomal protein S6 kinase delta-1 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), as well as variants 18-20, encodes isoform i.
      Source sequence(s)
      AL512449, AL583826, AL645860
      UniProtKB/TrEMBL
      B4DRK0
      Conserved Domains (2) summary
      cd05576
      Location:527 → 704
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl21453
      Location:1 → 69
      PKc_like; Protein Kinases, catalytic domain

    21. NM_001349663.2 → NP_001336592.1  ribosomal protein S6 kinase delta-1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22), as well as variants 5 and 23-30, encodes isoform d.
      Source sequence(s)
      AL512449, AL583826, AL645860
      Consensus CDS
      CCDS73030.1
      UniProtKB/TrEMBL
      A0A087X1U5
      Conserved Domains (1) summary
      cd05576
      Location:414 → 591
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    22. NM_001349664.2 → NP_001336593.1  ribosomal protein S6 kinase delta-1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23), as well as variants 5, 22, and 24-30, encodes isoform d.
      Source sequence(s)
      AL512449, AL583826, AL645860
      Consensus CDS
      CCDS73030.1
      UniProtKB/TrEMBL
      A0A087X1U5
      Conserved Domains (1) summary
      cd05576
      Location:414 → 591
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    23. NM_001349665.2 → NP_001336594.1  ribosomal protein S6 kinase delta-1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24), as well as variants 5, 23, and 25-30, encodes isoform d.
      Source sequence(s)
      AL512449, AL583826, AL645860
      Consensus CDS
      CCDS73030.1
      UniProtKB/TrEMBL
      A0A087X1U5
      Conserved Domains (1) summary
      cd05576
      Location:414 → 591
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    24. NM_001349666.2 → NP_001336595.1  ribosomal protein S6 kinase delta-1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25), as well as variants 5, 23, 24, and 26-30, encodes isoform d.
      Source sequence(s)
      AL512449, AL583826, AL645860
      Consensus CDS
      CCDS73030.1
      UniProtKB/TrEMBL
      A0A087X1U5
      Conserved Domains (1) summary
      cd05576
      Location:414 → 591
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    25. NM_001349667.2 → NP_001336596.1  ribosomal protein S6 kinase delta-1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (26), as well as variants 5, 23-25, and 27-30, encodes isoform d.
      Source sequence(s)
      AL512449, AL583826, AL645860
      Consensus CDS
      CCDS73030.1
      UniProtKB/TrEMBL
      A0A087X1U5
      Conserved Domains (1) summary
      cd05576
      Location:414 → 591
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    26. NM_001349668.2 → NP_001336597.1  ribosomal protein S6 kinase delta-1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (27), as well as variants 5, 23-26, and 28-30, encodes isoform d.
      Source sequence(s)
      AL512449, AL583826, AL645860
      Consensus CDS
      CCDS73030.1
      UniProtKB/TrEMBL
      A0A087X1U5
      Conserved Domains (1) summary
      cd05576
      Location:414 → 591
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    27. NM_001349669.2 → NP_001336598.1  ribosomal protein S6 kinase delta-1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (28), as well as variants 5, 23-27, 29, and 30, encodes isoform d.
      Source sequence(s)
      AL512449, AL583826, AL645860
      Consensus CDS
      CCDS73030.1
      UniProtKB/TrEMBL
      A0A087X1U5
      Conserved Domains (1) summary
      cd05576
      Location:414 → 591
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    28. NM_001349670.2 → NP_001336599.1  ribosomal protein S6 kinase delta-1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (29), as well as variants 5, 23-28, and 30, encodes isoform d.
      Source sequence(s)
      AL512449, AL583826, AL645860
      Consensus CDS
      CCDS73030.1
      UniProtKB/TrEMBL
      A0A087X1U5
      Conserved Domains (1) summary
      cd05576
      Location:414 → 591
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    29. NM_001349671.2 → NP_001336600.1  ribosomal protein S6 kinase delta-1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (30), as well as variants 5 and 23-29, encodes isoform d.
      Source sequence(s)
      AL512449, AL583826, AL645860
      Consensus CDS
      CCDS73030.1
      UniProtKB/TrEMBL
      A0A087X1U5
      Conserved Domains (1) summary
      cd05576
      Location:414 → 591
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    30. NM_001349672.2 → NP_001336601.1  ribosomal protein S6 kinase delta-1 isoform j

      Status: REVIEWED

      Description
      Transcript Variant: This variant (31) encodes isoform j.
      Source sequence(s)
      AL512449, AL583826, AL645860
      Conserved Domains (1) summary
      cl21453
      Location:414 → 561
      PKc_like; Protein Kinases, catalytic domain

    31. NM_012424.6 → NP_036556.2  ribosomal protein S6 kinase delta-1 isoform a

      See identical proteins and their annotated locations for NP_036556.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK122989, AL512449, AL583826, AL645860, DC323473
      Consensus CDS
      CCDS1513.1
      UniProtKB/Swiss-Prot
      B1APS8, B3KVM4, D3DTA4, Q8TDD3, Q96S38, Q9NSF4, Q9UL66
      UniProtKB/TrEMBL
      B4DRK0
      Related
      ENSP00000355927.3, ENST00000366960.8
      Conserved Domains (5) summary
      cd07287
      Location:11 → 128
      PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins
      smart00220
      Location:875 → 1056
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd02677
      Location:238 → 312
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:879 → 1056
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl21453
      Location:335 → 421
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. NR_146207.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL512449, AL583826, AL645860

    2. NR_146208.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL512449, AL583826, AL645860

    3. NR_146209.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL512449, AL583826, AL645860

    4. NR_146210.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL512449, AL583826, AL645860

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      213051241..213862735
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417936.1 → XP_047273892.1  ribosomal protein S6 kinase delta-1 isoform X5

      UniProtKB/TrEMBL
      B4DRK0

    2. XM_047417948.1 → XP_047273904.1  ribosomal protein S6 kinase delta-1 isoform X9

      UniProtKB/TrEMBL
      B4DRK0, F6RJM5

    3. XM_047417940.1 → XP_047273896.1  ribosomal protein S6 kinase delta-1 isoform X7

      UniProtKB/TrEMBL
      B4DRK0

    4. XM_047417933.1 → XP_047273889.1  ribosomal protein S6 kinase delta-1 isoform X4

      UniProtKB/TrEMBL
      B4DRK0

    5. XM_047417939.1 → XP_047273895.1  ribosomal protein S6 kinase delta-1 isoform X6

      UniProtKB/TrEMBL
      B4DRK0

    6. XM_047417945.1 → XP_047273901.1  ribosomal protein S6 kinase delta-1 isoform X8

      UniProtKB/TrEMBL
      B4DRK0

    7. XM_017001024.2 → XP_016856513.2  ribosomal protein S6 kinase delta-1 isoform X3

    8. XM_047417912.1 → XP_047273868.1  ribosomal protein S6 kinase delta-1 isoform X1

    9. XM_047417919.1 → XP_047273875.1  ribosomal protein S6 kinase delta-1 isoform X2

      UniProtKB/TrEMBL
      B4DRK0

    RNA

    1. XR_007058661.1 RNA Sequence

    2. XR_007058662.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      212294330..213102289
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335985.1 → XP_054191960.1  ribosomal protein S6 kinase delta-1 isoform X5

      UniProtKB/TrEMBL
      B4DRK0

    2. XM_054335989.1 → XP_054191964.1  ribosomal protein S6 kinase delta-1 isoform X9

      UniProtKB/TrEMBL
      B4DRK0, F6RJM5

    3. XM_054335987.1 → XP_054191962.1  ribosomal protein S6 kinase delta-1 isoform X7

      UniProtKB/TrEMBL
      B4DRK0

    4. XM_054335984.1 → XP_054191959.1  ribosomal protein S6 kinase delta-1 isoform X4

      UniProtKB/TrEMBL
      B4DRK0

    5. XM_054335986.1 → XP_054191961.1  ribosomal protein S6 kinase delta-1 isoform X6

      UniProtKB/TrEMBL
      B4DRK0

    6. XM_054335988.1 → XP_054191963.1  ribosomal protein S6 kinase delta-1 isoform X8

      UniProtKB/TrEMBL
      B4DRK0

    7. XM_054335983.1 → XP_054191958.1  ribosomal protein S6 kinase delta-1 isoform X3

    8. XM_054335981.1 → XP_054191956.1  ribosomal protein S6 kinase delta-1 isoform X1

    9. XM_054335982.1 → XP_054191957.1  ribosomal protein S6 kinase delta-1 isoform X2

      UniProtKB/TrEMBL
      B4DRK0

    RNA

    1. XR_008485992.1 RNA Sequence

    2. XR_008485993.1 RNA Sequence

    3. XR_008485994.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96S38.2 GenPept UniProtKB/Swiss-Prot:Q96S38

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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