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    IRF2BP1 interferon regulatory factor 2 binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 26145, updated on 10-Dec-2024

    Summary

    Official Symbol
    IRF2BP1provided by HGNC
    Official Full Name
    interferon regulatory factor 2 binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:21728
    See related
    Ensembl:ENSG00000170604 MIM:615331; AllianceGenome:HGNC:21728
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables transcription corepressor activity and ubiquitin protein ligase activity. Involved in protein polyubiquitination. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See IRF2BP1 in Genome Data Viewer
    Location:
    19q13.32
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (45883608..45886141, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (48711051..48713583, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46386866..46389399, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14823 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10800 Neighboring gene symplekin scaffold protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46329961-46330728 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46365430-46366068 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14824 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10801 Neighboring gene HNF4 motif-containing MPRA enhancer 173 Neighboring gene forkhead box A3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46385156-46385708 Neighboring gene HNF1 motif-containing MPRA enhancer 100 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46386261-46386812 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46386813-46387364 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10802 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10803 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14826 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14827 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14828 Neighboring gene Myb related transcription factor, partner of profilin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14829 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14830 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10805 Neighboring gene nanos C2HC-type zinc finger 2

    Genomic regions, transcripts, and products

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    interferon regulatory factor 2-binding protein 1
    Names
    IRF-2-binding protein 1
    probable E3 ubiquitin-protein ligase IRF2BP1
    probable RING-type E3 ubiquitin transferase IRF2BP1
    NP_056464.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015649.3NP_056464.1  interferon regulatory factor 2-binding protein 1

      See identical proteins and their annotated locations for NP_056464.1

      Status: VALIDATED

      Source sequence(s)
      AY278022, DA791039
      Consensus CDS
      CCDS12678.1
      UniProtKB/Swiss-Prot
      Q53EL7, Q6DC95, Q8IU81, Q9BRZ9, Q9Y4P4
      UniProtKB/TrEMBL
      B2RCD8
      Related
      ENSP00000307265.3, ENST00000302165.5
      Conserved Domains (3) summary
      cd16715
      Location:501556
      vRING-HC_IRF2BP1; variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein 1 (IRF-2BP1)
      pfam11261
      Location:859
      IRF-2BP1_2; Interferon regulatory factor 2-binding protein zinc finger
      NF033930
      Location:330422
      pneumo_PspA; pneumococcal surface protein A

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      45883608..45886141 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      48711051..48713583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)