NCAPG non-SMC condensin I complex subunit G [Homo sapiens (human)] - Gene

Summary

Official Symbol: NCAPGprovided by HGNC
Official Full Name: non-SMC condensin I complex subunit Gprovided by HGNC
Primary source: HGNC:HGNC:24304
See related: Ensembl:ENSG00000109805 MIM:606280; AllianceGenome:HGNC:24304
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CAPG; CHCG; YCG1; NY-MEL-3
Summary: This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Expression: Broad expression in bone marrow (RPKM 7.5), lymph node (RPKM 7.1) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4p15.31

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (17810979..17844865)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (17793327..17827212)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (17812602..17846488)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reduced miR-99a-3p levels in systemic lupus erythematosus may promote B cell proliferation via NCAPG and the PI3K/AKT signaling pathway.
Title: Reduced miR-99a-3p levels in systemic lupus erythematosus may promote B cell proliferation via NCAPG and the PI3K/AKT signaling pathway.
The Diagnostic and Therapeutic Value of NCAPG as a Proposed Biomarker Candidate in Acute Liver Failure.
Title: The Diagnostic and Therapeutic Value of NCAPG as a Proposed Biomarker Candidate in Acute Liver Failure.
Galectin-1-mediated high NCAPG expression correlates with poor prognosis in gastric cancer.
Title: Galectin-1-mediated high NCAPG expression correlates with poor prognosis in gastric cancer.
NCAPG as a novel prognostic biomarker in numerous cancers: a meta-analysis and bioinformatics analysis.
Title: NCAPG as a novel prognostic biomarker in numerous cancers: a meta-analysis and bioinformatics analysis.
The U2AF65/circNCAPG/RREB1 feedback loop promotes malignant phenotypes of glioma stem cells through activating the TGF-beta pathway.
Title: The U2AF65/circNCAPG/RREB1 feedback loop promotes malignant phenotypes of glioma stem cells through activating the TGF-β pathway.
The role of NCAPG in various of tumors.
Title: The role of NCAPG in various of tumors.
NCAPG Promotes Pulmonary Artery Smooth Muscle Cell Proliferation as a Promising Therapeutic Target of Idiopathic Pulmonary Hypertension: Bioinformatics Analysis and Experiment Verification.
Title: NCAPG Promotes Pulmonary Artery Smooth Muscle Cell Proliferation as a Promising Therapeutic Target of Idiopathic Pulmonary Hypertension: Bioinformatics Analysis and Experiment Verification.
Overexpression of NCAPG in ovarian cancer is associated with ovarian cancer proliferation and apoptosis via p38 MAPK signaling pathway.
Title: Overexpression of NCAPG in ovarian cancer is associated with ovarian cancer proliferation and apoptosis via p38 MAPK signaling pathway.
NCAPG promotes tumorigenesis of bladder cancer through NF-kappaB signaling pathway.
Title: NCAPG promotes tumorigenesis of bladder cancer through NF-κB signaling pathway.
NCAPG Promotes the Proliferation of Renal Clear Cell Carcinoma via Mediating with CDK1.
Title: NCAPG Promotes the Proliferation of Renal Clear Cell Carcinoma via Mediating with CDK1.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Many sequence variants affecting diversity of adult human height. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-R67597 (e-PCR)
- UniSTS:27682

RH103028 (e-PCR)
- UniSTS:97362

RH102048 (e-PCR)
- UniSTS:96382

A009L13 (e-PCR)
- UniSTS:82591

SHGC-67761 (e-PCR)
- UniSTS:66492

G32642 (e-PCR)
- UniSTS:117225

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in mitotic chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic chromosome condensation	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic chromosome condensation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of chromosome condensation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chromosome separation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in condensed chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in condensed chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in condensed nuclear chromosome	ISO Inferred from Sequence Orthology more info
part_of condensin complex	IDA Inferred from Direct Assay more info	PubMed
part_of condensin complex	NAS Non-traceable Author Statement more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	HDA more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: condensin complex subunit 3

Names: XCAP-G homolog; chromosome condensation protein G; chromosome-associated protein G; condensin subunit CAP-G; melanoma antigen NY-MEL-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022346.5 → NP_071741.2 condensin complex subunit 3

See identical proteins and their annotated locations for NP_071741.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.

Source sequence(s)

AC005768, AF331796, BG398543, DB451361

Consensus CDS

CCDS3424.1

UniProtKB/Swiss-Prot

Q3MJE0, Q96SV9, Q9BPX3, Q9BUR3, Q9BVY1, Q9H914, Q9H9Z6, Q9HBI9

UniProtKB/TrEMBL

Q6NUR1

Related

ENSP00000251496.2, ENST00000251496.7

Conserved Domains (3) summary

pfam12719
Location:559 → 853

Cnd3; Nuclear condensing complex subunits, C-term domain

pfam13646
Location:103 → 204

HEAT_2; HEAT repeats

sd00044
Location:208 → 234

HEAT; HEAT repeat [structural motif]

RNA

NR_073124.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC005768, BC143383, BG398543, DB451361

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p14 Primary Assembly

Range

17810979..17844865

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017008543.3 → XP_016864032.1 condensin complex subunit 3 isoform X1

UniProtKB/TrEMBL

Q6NUR1
XM_047416072.1 → XP_047272028.1 condensin complex subunit 3 isoform X2
XM_047416073.1 → XP_047272029.1 condensin complex subunit 3 isoform X3