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    JPT2 Jupiter microtubule associated homolog 2 [ Homo sapiens (human) ]

    Gene ID: 90861, updated on 27-Nov-2024

    Summary

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    Official Symbol
    JPT2provided by HGNC
    Official Full Name
    Jupiter microtubule associated homolog 2provided by HGNC
    Primary source
    HGNC:HGNC:14137
    See related
    Ensembl:ENSG00000206053 MIM:619241; AllianceGenome:HGNC:14137
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L11; HN1L; C16orf34
    Summary
    Involved in endocytosis involved in viral entry into host cell and regulation of calcium-mediated signaling. Located in cytosol; nucleus; and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in prostate (RPKM 16.7), placenta (RPKM 16.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See JPT2 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (1678279..1702086)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (1694127..1717934)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1728280..1752087)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 140 Neighboring gene uncharacterized LOC105371046 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10227 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:1662256-1662756 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:1662757-1663257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10230 Neighboring gene cramped chromatin regulator homolog 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:1696049-1696268 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:1701290-1701464 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1728137-1728772 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1739823-1740519 Neighboring gene Sharpr-MPRA regulatory region 11614 Neighboring gene Sharpr-MPRA regulatory region 3989 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1755527-1756391 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6998 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6999 Neighboring gene MAPK8IP3 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10231 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10232 Neighboring gene mitogen-activated protein kinase 8 interacting protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10233 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10234 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1784965-1785466 Neighboring gene microRNA 3177

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. JPT2 Affects Trophoblast Functions and Macrophage Polarization and Metabolism, and Acts as a Potential Therapeutic Target for Recurrent Spontaneous Abortion. Chen X, et al. Adv Sci (Weinh), 2024 Apr. PMID 38417123, Free PMC Article
    2. Overexpression of HN1L promotes cell malignant proliferation in non-small cell lung cancer. Li L, et al. Cancer Biol Ther, 2017 Nov 2. PMID 29053395, Free PMC Article
    3. HN1L-mediated transcriptional axis AP-2γ/METTL13/TCF3-ZEB1 drives tumor growth and metastasis in hepatocellular carcinoma. Li L, et al. Cell Death Differ, 2019 Nov. PMID 30778199, Free PMC Article
    4. HN1L promotes invasion and metastasis of the esophagogastric junction adenocarcinoma. Wang ZY, et al. Thorac Cancer, 2021 Mar. PMID 33471419, Free PMC Article
    5. Essential requirement for JPT2 in NAADP-evoked Ca(2+) signaling. Gunaratne GS, et al. Sci Signal, 2021 Mar 23. PMID 33758061, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. JPT2 Affects Trophoblast Functions and Macrophage Polarization and Metabolism, and Acts as a Potential Therapeutic Target for Recurrent Spontaneous Abortion.
      Title: JPT2 Affects Trophoblast Functions and Macrophage Polarization and Metabolism, and Acts as a Potential Therapeutic Target for Recurrent Spontaneous Abortion.
    2. Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12.
      Title: Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12.
    3. HN1L/AP-2gamma/PLK1 signaling drives tumor progression and chemotherapy resistance in esophageal squamous cell carcinoma.
      Title: HN1L/AP-2γ/PLK1 signaling drives tumor progression and chemotherapy resistance in esophageal squamous cell carcinoma.
    4. HN1L promotes stem cell-like properties by regulating TGF-beta signaling pathway through targeting FOXP2 in prostate cancer.
      Title: HN1L promotes stem cell-like properties by regulating TGF-β signaling pathway through targeting FOXP2 in prostate cancer.
    5. HN1L/JPT2: A signaling protein that connects NAADP generation to Ca(2+) microdomain formation.
      Title: HN1L/JPT2: A signaling protein that connects NAADP generation to Ca(2+) microdomain formation.
    6. HN1L promotes invasion and metastasis of the esophagogastric junction adenocarcinoma.
      Title: HN1L promotes invasion and metastasis of the esophagogastric junction adenocarcinoma.
    7. HN1L promotes migration and invasion of breast cancer by up-regulating the expression of HMGB1.
      Title: HN1L promotes migration and invasion of breast cancer by up-regulating the expression of HMGB1.
    8. Essential requirement for JPT2 in NAADP-evoked Ca(2+) signaling.
      Title: Essential requirement for JPT2 in NAADP-evoked Ca(2+) signaling.
    9. HN1L-mediated transcriptional axis AP-2gamma/METTL13/TCF3-ZEB1 drives tumor growth and metastasis in hepatocellular carcinoma.
      Title: HN1L-mediated transcriptional axis AP-2γ/METTL13/TCF3-ZEB1 drives tumor growth and metastasis in hepatocellular carcinoma.
    10. reveal that breast cancer stem cell (BCSC) in triple-negative breast cancer depend on the transcription regulator HN1L for the sustained activation of the LEPR-STAT3 pathway, which makes it a potentially important target for both prognosis and BCSC therapy.
      Title: HN1L Promotes Triple-Negative Breast Cancer Stem Cells through LEPR-STAT3 Pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: CRAMP1

    Homology

    Clone Names

    • FLJ13092, KIAA1426

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis involved in viral entry into host cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    jupiter microtubule associated homolog 2
    Names
    CRAMP_1 like
    HN1 like
    HN1-like protein
    hematological and neurological expressed 1 like
    hematological and neurological expressed 1-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001434664.1 → NP_001421593.1  jupiter microtubule associated homolog 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL031009, AL031710

    2. NM_001434665.1 → NP_001421594.1  jupiter microtubule associated homolog 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL031009, AL031710

    3. NM_001434666.1 → NP_001421595.1  jupiter microtubule associated homolog 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL031009, AL031710

    4. NM_001434667.1 → NP_001421596.1  jupiter microtubule associated homolog 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL031009, AL031710

    5. NM_001434668.1 → NP_001421597.1  jupiter microtubule associated homolog 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL031009, AL031710

    6. NM_144570.3 → NP_653171.1  jupiter microtubule associated homolog 2 isoform 4

      See identical proteins and their annotated locations for NP_653171.1

      Status: VALIDATED

      Source sequence(s)
      AK023154, AL031710, BC060853, BM474060, BM837125
      Consensus CDS
      CCDS10441.1
      UniProtKB/Swiss-Prot
      B1AJY2, B4DLH4, Q6EIC7, Q9H910
      UniProtKB/TrEMBL
      A6NGP5, B4E1X8
      Related
      ENSP00000248098.3, ENST00000248098.8
      Conserved Domains (1) summary
      pfam17054
      Location:10 → 48
      JUPITER; Microtubule-Associated protein Jupiter

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      1678279..1702086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      1694127..1717934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H910.1 GenPept UniProtKB/Swiss-Prot:Q9H910

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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