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    Adam4 a disintegrin and metallopeptidase domain 4 [ Mus musculus (house mouse) ]

    Gene ID: 11498, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Adam4provided by MGI
    Official Full Name
    a disintegrin and metallopeptidase domain 4provided by MGI
    Primary source
    MGI:MGI:104731
    See related
    Ensembl:ENSMUSG00000072972 AllianceGenome:MGI:104731
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    tMDCV
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in male gonad development and proteolysis. Located in external side of plasma membrane and sperm head plasma membrane. Is expressed in glossopharyngeal ganglion and trigeminal ganglion. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See Adam4 in Genome Data Viewer
    Location:
    12 D1; 12 37.66 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (81466217..81468813, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (81419443..81422039, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene synaptojanin 2 binding protein Cox16 readthrough Neighboring gene cytochrome c oxidase assembly protein 16 Neighboring gene predicted gene 4787 Neighboring gene heat shock protein 1 (chaperonin 10), pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_32671 Neighboring gene STARR-seq mESC enhancer starr_32672 Neighboring gene STARR-seq mESC enhancer starr_32673 Neighboring gene STARR-positive B cell enhancer ABC_E9388 Neighboring gene STARR-positive B cell enhancer ABC_E7157 Neighboring gene STARR-seq mESC enhancer starr_32674 Neighboring gene synaptojanin 2 binding protein Neighboring gene a disintegrin and metallopeptidase domain 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of mouse extracellular-signal-regulated protein kinase 3 as a unique gene product of 100 kDa. Turgeon B, et al. Biochem J, 2000 Feb 15. PMID 10657254, Free PMC Article
    2. Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloprotease genes independent of TGF-beta. Ballock RT, et al. J Cell Physiol, 1994 May. PMID 8163572
    3. ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain. Wolfsberg TG, et al. Dev Biol, 1995 May. PMID 7750654
    4. Characterization and comparative genomic analysis of intronless Adams with testicular gene expression. Choi I, et al. Genomics, 2004 Apr. PMID 15028286
    5. Impaired motor coordination in mice that lack punc. Yang W, et al. Mol Cell Biol, 2001 Sep. PMID 11486040, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in male gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sperm head plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm head plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    a disintegrin and metallopeptidase domain 4
    Names
    a disintegrin and metalloprotease domain (ADAM) 4
    a disintegrin and metalloprotease domain 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009620.2 → NP_033750.1  a disintegrin and metallopeptidase domain 4 precursor

      See identical proteins and their annotated locations for NP_033750.1

      Status: VALIDATED

      Source sequence(s)
      AC132391, AV264697, AV274654, BC150481, BE956537, BF458290
      Consensus CDS
      CCDS26019.1
      UniProtKB/TrEMBL
      Q8CGQ2
      Related
      ENSMUSP00000082427.4, ENSMUST00000085319.4
      Conserved Domains (5) summary
      smart00050
      Location:429 → 503
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:505 → 648
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:213 → 406
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:213 → 405
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:60 → 163
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      81466217..81468813 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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