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    Snx29 sorting nexin 29 [ Mus musculus (house mouse) ]

    Gene ID: 74478, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snx29provided by MGI
    Official Full Name
    sorting nexin 29provided by MGI
    Primary source
    MGI:MGI:1921728
    See related
    Ensembl:ENSMUSG00000071669 AllianceGenome:MGI:1921728
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm930; Gm1737; Gm11170; Rundc2a; 4933437K13Rik
    Summary
    Predicted to enable phosphatidylinositol binding activity. Orthologous to several human genes including SNX29 (sorting nexin 29). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in kidney adult (RPKM 7.8), spleen adult (RPKM 2.1) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Snx29 in Genome Data Viewer
    Location:
    16 A1; 16 6.46 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (11140719..11576959)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (11322861..11759095)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:11254345-11254532 Neighboring gene STARR-seq mESC enhancer starr_40101 Neighboring gene microRNA 1945 Neighboring gene STARR-positive B cell enhancer mm9_chr16:11322815-11323116 Neighboring gene tumor necrosis factor receptor superfamily, member 17 Neighboring gene STARR-positive B cell enhancer mm9_chr16:11385888-11386189 Neighboring gene STARR-positive B cell enhancer ABC_E5524 Neighboring gene STARR-positive B cell enhancer ABC_E1181 Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 15 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40106 Neighboring gene STARR-seq mESC enhancer starr_40107 Neighboring gene tyrosine-protein kinase SgK223 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40108 Neighboring gene predicted gene, 32100 Neighboring gene STARR-seq mESC enhancer starr_40110 Neighboring gene STARR-seq mESC enhancer starr_40111 Neighboring gene RIKEN cDNA 4833415N18 gene Neighboring gene calcineurin-like phosphoesterase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_40112 Neighboring gene predicted gene 9961

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Phox (PX) domain proteins and membrane traffic. Seet LF, et al. Biochim Biophys Acta, 2006 Aug. PMID 16782399
    2. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
    3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-29
    Names
    RUN domain containing 2A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290148.1 → NP_001277077.1  sorting nexin-29 isoform b

      See identical proteins and their annotated locations for NP_001277077.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AK017102, CR521963
      Consensus CDS
      CCDS79422.1
      UniProtKB/Swiss-Prot
      Q9D3S3
      Related
      ENSMUSP00000093993.3, ENSMUST00000096273.9
      Conserved Domains (2) summary
      cd07277
      Location:319 → 436
      PX_RUN; The phosphoinositide binding Phox Homology domain of uncharacterized proteins containing PX and RUN domains
      pfam10211
      Location:123 → 202
      Ax_dynein_light; Axonemal dynein light chain

    2. NM_001403235.1 → NP_001390164.1  sorting nexin-29 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154233, AC154509, AC165252, AC167720

    3. NM_001403236.1 → NP_001390165.1  sorting nexin-29 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154233, AC165252, AC167720

    4. NM_001403237.1 → NP_001390166.1  sorting nexin-29 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC154233, AC165252, AC167720

    5. NM_001403238.1 → NP_001390167.1  sorting nexin-29 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154233, AC165252, AC167720

    6. NM_001403239.1 → NP_001390168.1  sorting nexin-29 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC154233, AC154509, AC165252, AC167720

    7. NM_028964.5 → NP_083240.2  sorting nexin-29 isoform a

      See identical proteins and their annotated locations for NP_083240.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC154233, AC154509, AC165252, AC167720
      Consensus CDS
      CCDS27963.2
      UniProtKB/Swiss-Prot
      Q8K050, Q9D3S3
      Related
      ENSMUSP00000138025.2, ENSMUST00000180792.8
      Conserved Domains (3) summary
      cd07277
      Location:661 → 778
      PX_RUN; The phosphoinositide binding Phox Homology domain of uncharacterized proteins containing PX and RUN domains
      pfam02759
      Location:44 → 179
      RUN; RUN domain
      pfam10211
      Location:465 → 544
      Ax_dynein_light; Axonemal dynein light chain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      11140719..11576959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160170.1 → XP_036016063.1  sorting nexin-29 isoform X6

      Conserved Domains (3) summary
      cd07277
      Location:529 → 646
      PX_RUN; The phosphoinositide binding Phox Homology domain of uncharacterized proteins containing PX and RUN domains
      smart00593
      Location:1 → 45
      RUN; domain involved in Ras-like GTPase signaling
      COG1196
      Location:339 → 501
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_030249318.1 → XP_030105178.1  sorting nexin-29 isoform X2

      Conserved Domains (3) summary
      cd07277
      Location:606 → 723
      PX_RUN; The phosphoinositide binding Phox Homology domain of uncharacterized proteins containing PX and RUN domains
      COG1196
      Location:416 → 578
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam02759
      Location:1 → 121
      RUN; RUN domain

    3. XM_030249320.2 → XP_030105180.1  sorting nexin-29 isoform X9

      Conserved Domains (2) summary
      cd07277
      Location:509 → 626
      PX_RUN; The phosphoinositide binding Phox Homology domain of uncharacterized proteins containing PX and RUN domains
      COG1196
      Location:319 → 481
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    4. XM_036160171.1 → XP_036016064.1  sorting nexin-29 isoform X7

      Conserved Domains (3) summary
      cd07277
      Location:528 → 645
      PX_RUN; The phosphoinositide binding Phox Homology domain of uncharacterized proteins containing PX and RUN domains
      smart00593
      Location:1 → 45
      RUN; domain involved in Ras-like GTPase signaling
      COG1196
      Location:338 → 500
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. XM_030249319.1 → XP_030105179.1  sorting nexin-29 isoform X8

      Conserved Domains (2) summary
      cd07277
      Location:510 → 627
      PX_RUN; The phosphoinositide binding Phox Homology domain of uncharacterized proteins containing PX and RUN domains
      COG1196
      Location:320 → 482
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    6. XM_006522670.5 → XP_006522733.1  sorting nexin-29 isoform X10

      Conserved Domains (2) summary
      cd07277
      Location:320 → 437
      PX_RUN; The phosphoinositide binding Phox Homology domain of uncharacterized proteins containing PX and RUN domains
      COG1196
      Location:130 → 292
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    7. XM_006522672.5 → XP_006522735.1  sorting nexin-29 isoform X11

      See identical proteins and their annotated locations for XP_006522735.1

      Conserved Domains (2) summary
      cd07277
      Location:304 → 421
      PX_RUN; The phosphoinositide binding Phox Homology domain of uncharacterized proteins containing PX and RUN domains
      COG1196
      Location:114 → 276
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001163498.1: Suppressed sequence

      Description
      NM_001163498.1: This RefSeq was permanently suppressed because the CDS was partial.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D3S3.2 GenPept UniProtKB/Swiss-Prot:Q9D3S3

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