irx4.L iroquois homeobox 4 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: irx4.L
Official Full Name: iroquois homeobox 4 L homeolog
Primary source: Xenbase:XB-GENE-865388
Locus tag: XELAEV_18031334mg
See related: EnsemblRapid:ENSXLAG00005032574 AllianceGenome:Xenbase:XB-GENE-865388
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: irx4; Xiro4; irxa3; irx4-a; irx4-b; iroquois-4
Summary: Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within brain development; dorsal/ventral pattern formation; and proximal/distal pattern formation. Predicted to be located in nucleus. Is expressed in cardiovascular system; ectoderm; nervous system; and pharyngeal arch. Orthologous to human IRX4 (iroquois homeobox 4). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 6L

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	6L	NC_054381.1 (70807645..70817160, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	6L	NC_030734.1 (65041248..65050835, complement)

Chromosome 6L - NC_054381.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dorsal/ventral pattern formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
NOT acts_upstream_of_or_within pronephros development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proximal/distal pattern formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proximal/distal pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: iroquois-class homeodomain protein irx-4-A

Names: Iroquois homeobox protein 4-A; iroquois-4 homeobox transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001096735.1 → NP_001090204.1 iroquois-class homeodomain protein irx-4-A

See identical proteins and their annotated locations for NP_001090204.1

Status: PROVISIONAL

Source sequence(s)

AF338157

UniProtKB/Swiss-Prot

Q90XW6

UniProtKB/TrEMBL

A0A974CP08

Related

ENSXLAP00005097591.1, ENSXLAT00005099383.1

Conserved Domains (2) summary

smart00548
Location:357 → 370

IRO; Motif in Iroquois-class homeodomain proteins (only). Unknown function

pfam05920
Location:159 → 198

Homeobox_KN; Homeobox KN domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054381.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

70807645..70817160 complement

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GenBank, FASTA, Sequence Viewer (Graphics)