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    MOG myelin oligodendrocyte glycoprotein [ Homo sapiens (human) ]

    Gene ID: 4340, updated on 27-Nov-2024

    Summary

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    Official Symbol
    MOGprovided by HGNC
    Official Full Name
    myelin oligodendrocyte glycoproteinprovided by HGNC
    Primary source
    HGNC:HGNC:7197
    See related
    Ensembl:ENSG00000204655 MIM:159465; AllianceGenome:HGNC:7197
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BTN6; BTNL11; MOGIG2; NRCLP7
    Summary
    The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward brain (RPKM 52.4) See more
    Orthologs
    mouse all
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    Genomic context

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    See MOG in Genome Data Viewer
    Location:
    6p22.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (29657092..29672365)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (29531788..29547063)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (29624869..29640142)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type B receptor subunit 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:29589456-29590006 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:29590007-29590556 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:29592149-29592734 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:29596552-29597357 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:29598769-29599270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:29610193-29610692 Neighboring gene SUMO2 pseudogene 1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:29616349-29616969 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:29622853-29623353 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:29627633-29628069 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:29628451-29629365 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:29629366-29630280 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:29630281-29631194 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:29634045-29634654 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:29634655-29635264 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:29647510-29648030 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:29648031-29648552 Neighboring gene ZFP57 zinc finger protein Neighboring gene ReSE screen-validated silencer GRCh37_chr6:29671001-29671115 Neighboring gene zinc finger DHHC-type containing 20 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Transmission disequilibrium study of an oligodendrocyte and myelin glycoprotein gene allele in 431 families with an autistic proband. Martin I, et al. Neurosci Res, 2007 Dec. PMID 17897745
    2. Antibodies to myelin oligodendrocyte glycoprotein in idiopathic optic neuritis. Nakajima H, et al. BMJ Open, 2015 Apr 2. PMID 25838512, Free PMC Article
    3. Immune modulation by a tolerogenic myelin oligodendrocyte glycoprotein (MOG)10-60 containing fusion protein in the marmoset experimental autoimmune encephalomyelitis model. Kap YS, et al. Clin Exp Immunol, 2015 Apr. PMID 25393803, Free PMC Article
    4. The role of myelin oligodendrocyte glycoprotein in autoimmune demyelination: a target for multiple sclerosis therapy? Lee DH, et al. Expert Opin Ther Targets, 2012 May. PMID 22494461
    5. Complement activating antibodies to myelin oligodendrocyte glycoprotein in neuromyelitis optica and related disorders. Mader S, et al. J Neuroinflammation, 2011 Dec 28. PMID 22204662, Free PMC Article

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Differentiated pattern of complement system activation between MOG-IgG-associated disease and AQP4-IgG-positive neuromyelitis optica spectrum disorder.
      Title: Differentiated pattern of complement system activation between MOG-IgG-associated disease and AQP4-IgG-positive neuromyelitis optica spectrum disorder.
    2. Barriers to access and unmet needs to neuromyelitis optica spectrum disorders care in an Argentinean cohort.
      Title: Barriers to access and unmet needs to neuromyelitis optica spectrum disorders care in an Argentinean cohort.
    3. MOG-specific T cell response amplified in para- and post-SAR-CoV-2 infection in myelin oligodendrocyte glycoprotein antibody-associated disease.
      Title: MOG-specific T cell response amplified in para- and post-SAR-CoV-2 infection in myelin oligodendrocyte glycoprotein antibody-associated disease.
    4. White matter volume and myelin oligodendrocyte glycoprotein (MOG) microsatellites in pediatric obsessive-compulsive disorder.
      Title: White matter volume and myelin oligodendrocyte glycoprotein (MOG) microsatellites in pediatric obsessive-compulsive disorder.
    5. Myelin Oligodendrocyte Glycoprotein as an Autoantigen in Inflammatory Demyelinating Diseases of the Central Nervous System.
      Title: Myelin Oligodendrocyte Glycoprotein as an Autoantigen in Inflammatory Demyelinating Diseases of the Central Nervous System.
    6. Imperative role of glycosylation in human MOG-HLA interaction: molecular insights of MOG-Ab associated demyelination.
      Title: Imperative role of glycosylation in human MOG-HLA interaction: molecular insights of MOG-Ab associated demyelination.
    7. Differential Binding of Autoantibodies to MOG Isoforms in Inflammatory Demyelinating Diseases.
      Title: Differential Binding of Autoantibodies to MOG Isoforms in Inflammatory Demyelinating Diseases.
    8. Comparative study of AQP4 antibody-related diseases and MOG antibody-related diseases among the population in Hunan, China.
      Title: Comparative study of AQP4 antibody-related diseases and MOG antibody-related diseases among the population in Hunan, China.
    9. Clinical profile, imaging features and short term visual outcomes of Indian optic neuritis patients with and without seromarkers for myelin oligodendrocyte glycoprotein and neuromyelitis optica.
      Title: Clinical profile, imaging features and short term visual outcomes of Indian optic neuritis patients with and without seromarkers for myelin oligodendrocyte glycoprotein and neuromyelitis optica.
    10. Clinical and laboratory features distinguishing MOG antibody disease from multiple sclerosis and AQP4 antibody-positive neuromyelitis optica.
      Title: Clinical and laboratory features distinguishing MOG antibody disease from multiple sclerosis and AQP4 antibody-positive neuromyelitis optica.
    Submit: New GeneRIF Correction See all GeneRIFs (73)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Narcolepsy 7
    MedGen: C3280266 OMIM: 614250 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
    EBI GWAS Catalog
    Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC26137

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in central nervous system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myelin-oligodendrocyte glycoprotein
    Names
    MOG AluA
    MOG AluB
    MOG Ig-AluB
    MOG alpha-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031873.1 RefSeqGene

      Range
      5112..20385
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001008228.3 → NP_001008229.1  myelin-oligodendrocyte glycoprotein isoform alpha3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha3) has multiple differences in the coding region, compared to variant beta1. Alpha type variants use an alternative splice site at the 3' end, compared to isoform beta1. The resulting isoform (alpha3) is shorter and contains a shorter and distinct C-terminus, compared to isoform beta1.
      Source sequence(s)
      AL119259, DA139582, DA140757, U18843, U64564
      Consensus CDS
      CCDS34369.1
      UniProtKB/TrEMBL
      A0A0G2JHA9
      Related
      ENSP00000379932.3, ENST00000396704.7
      Conserved Domains (2) summary
      cd05713
      Location:46 → 144
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:40 → 144
      IG_like; Immunoglobulin like

    2. NM_001008229.3 → NP_001008230.1  myelin-oligodendrocyte glycoprotein isoform beta2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta2) lacks an in-frame segment of the coding region, compared to variant beta1. It encodes a shorter isoform (beta2), that is missing an internal segment, compared to isoform beta1.
      Source sequence(s)
      AL119259, AY566853, DA139582, DA140757, U64564
      Consensus CDS
      CCDS34368.1
      UniProtKB/TrEMBL
      A0A0G2JI49
      Related
      ENSP00000366088.4, ENST00000376891.8
      Conserved Domains (2) summary
      cd05713
      Location:46 → 144
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:40 → 144
      IG_like; Immunoglobulin like

    3. NM_001170418.2 → NP_001163889.1  myelin-oligodendrocyte glycoprotein isoform alpha6 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha6) lacks an alternate in-frame exon in the 5' coding region and differs in the 3' coding region and 3' UTR, compared to variant beta1. The encoded isoform (alpha6) has a distinct C-terminus and is shorter than isoform beta1.
      Source sequence(s)
      AL119259, AY566847, DA139582, DA140757, U64564
      Consensus CDS
      CCDS54977.1
      UniProtKB/TrEMBL
      E9PG44
      Related
      ENSP00000420350.1, ENST00000490427.5

    4. NM_001363610.2 → NP_001350539.1  myelin-oligodendrocyte glycoprotein isoform 10 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) represents the longest transcript and encodes the longest isoform (10).
      Source sequence(s)
      AL645936, BC035938
      Consensus CDS
      CCDS87379.1
      UniProtKB/TrEMBL
      A0A0G2JHM8
      Related
      ENSP00000366091.4, ENST00000376894.8
      Conserved Domains (1) summary
      cd05713
      Location:46 → 144
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)

    5. NM_002433.5 → NP_002424.3  myelin-oligodendrocyte glycoprotein isoform beta1 precursor

      See identical proteins and their annotated locations for NP_002424.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta1) encodes the beta1 isoform, also known as isoform 1.
      Source sequence(s)
      AL119259, AY566852, DA139582, DA140757, U64564
      Consensus CDS
      CCDS4667.1
      UniProtKB/TrEMBL
      Q5SSB8
      Related
      ENSP00000366095.3, ENST00000376898.7
      Conserved Domains (2) summary
      cd05713
      Location:46 → 144
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:40 → 144
      IG_like; Immunoglobulin like

    6. NM_206809.4 → NP_996532.2  myelin-oligodendrocyte glycoprotein isoform alpha1 precursor

      See identical proteins and their annotated locations for NP_996532.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha1) contains an additional segment in the coding region compared to variant beta1. Alpha type variants use an alternative splice site at the 3' end, compared to variant beta1. The resulting isoform (alpha1), also known as isoform 2, contains a shorter and distinct C-terminus compared to isoform beta1.
      Source sequence(s)
      AL119259, DA139582, DA140757, U64564, X74511
      Consensus CDS
      CCDS34370.1
      UniProtKB/Swiss-Prot
      A6NDR4, A6NNJ9, A8MY31, B0UZR9, E9PGF0, F8W9D5, O00713, O00714, O00715, Q13054, Q13055, Q14855, Q16653, Q29ZN8, Q56UY0, Q5JNX7, Q5JNY1, Q5JNY2, Q5JNY4, Q5SSB5, Q5SSB6, Q5STL9, Q5STM0, Q5STM1, Q5STM2, Q5STM5, Q5SUK5, Q5SUK7, Q5SUK8, Q5SUK9, Q5SUL0, Q5SUL1, Q8IYG5, Q92891, Q92892, Q92893, Q92894, Q92895, Q93053, Q96KU9, Q96KV0, Q96KV1, Q99605
      UniProtKB/TrEMBL
      Q5SSB8
      Related
      ENSP00000366115.3, ENST00000376917.8
      Conserved Domains (2) summary
      cd05713
      Location:46 → 144
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:40 → 144
      IG_like; Immunoglobulin like

    7. NM_206810.4 → NP_996533.2  myelin-oligodendrocyte glycoprotein isoform beta5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta5) lacks an in-frame segment of the coding region, compared to variant beta1. It encodes a shorter isoform (beta5), also known as isoform 3, that is missing an internal segment, compared to isoform beta1.
      Source sequence(s)
      AL119259, DA139582, DA140757, U18803, U64564
      Consensus CDS
      CCDS34367.1
      UniProtKB/TrEMBL
      A0A0G2JIU9
      Related
      ENSP00000379929.2, ENST00000396701.6
      Conserved Domains (2) summary
      cd05713
      Location:46 → 144
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:40 → 144
      IG_like; Immunoglobulin like

    8. NM_206811.4 → NP_996534.2  myelin-oligodendrocyte glycoprotein isoform beta3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta3) has multiple differences in the coding region, compared to variant beta1. The resulting isoform (beta3), also known as isoform 4, is shorter, compared to isoform beta1.
      Source sequence(s)
      AL119259, DA139582, DA140757, U18840, U64564
      Consensus CDS
      CCDS34366.1
      UniProtKB/TrEMBL
      A0A0G2JKI0
      Related
      ENSP00000417405.1, ENST00000494692.5
      Conserved Domains (2) summary
      cd05713
      Location:46 → 144
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:40 → 144
      IG_like; Immunoglobulin like

    9. NM_206812.4 → NP_996535.2  myelin-oligodendrocyte glycoprotein isoform alpha2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha2) has multiple differences in the coding region, compared to variant beta1. Alpha type variants use an alternative splice site at the 3' end, compared to isoform beta1. The resulting isoform (alpha2), also known as isoform 5, is shorter and contains a shorter and distinct C-terminus, compared to isoform beta1.
      Source sequence(s)
      AL119259, DA139582, DA140757, U18799, U64564
      Consensus CDS
      CCDS47394.1
      UniProtKB/TrEMBL
      A0A0G2JI49
      Related
      ENSP00000410866.2, ENST00000431798.6
      Conserved Domains (2) summary
      cd05713
      Location:46 → 144
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:40 → 144
      IG_like; Immunoglobulin like

    10. NM_206814.6 → NP_996537.3  myelin-oligodendrocyte glycoprotein isoform alpha5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha5) lacks an alternate in-frame exon in the 5' coding region and differs in the 3' coding region and 3' UTR, compared to variant beta1. The encoded isoform (alpha5) has a distinct C-terminus and is shorter than isoform beta1.
      Source sequence(s)
      AK308949, AL119259, DA139582, DA140757, U64564
      Consensus CDS
      CCDS47395.2
      UniProtKB/TrEMBL
      A0A0G2JHB7
      Related
      ENSP00000366085.2, ENST00000376888.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      29657092..29672365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      922801..938073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      1143564..1158838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

      Range
      922637..937911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

      Range
      922209..937479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

      Range
      922473..937739
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

      Range
      922592..937866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

      Range
      966127..981397
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      29531788..29547063
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_206813.4: Suppressed sequence

      Description
      NM_206813.4: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q16653.2 GenPept UniProtKB/Swiss-Prot:Q16653

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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