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    TAS2R50 taste 2 receptor member 50 [ Homo sapiens (human) ]

    Gene ID: 259296, updated on 27-Nov-2024

    Summary

    Official Symbol
    TAS2R50provided by HGNC
    Official Full Name
    taste 2 receptor member 50provided by HGNC
    Primary source
    HGNC:HGNC:18882
    See related
    Ensembl:ENSG00000212126 MIM:609627; AllianceGenome:HGNC:18882
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    T2R50; T2R51; TAS2R51
    Summary
    TAS2R50 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). See also TAS2R10 (MIM 604791).[supplied by OMIM, Mar 2008]
    Orthologs
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    Genomic context

    See TAS2R50 in Genome Data Viewer
    Location:
    12p13.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (10985913..10986912, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (10858932..10859931, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (11138512..11139511, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene PRH1-PRR4 readthrough Neighboring gene proline rich protein HaeIII subfamily 1 Neighboring gene PRH1-TAS2R14 readthrough Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:11094509-11095708 Neighboring gene taste 2 receptor member 14 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:11127502-11128380 Neighboring gene taste 2 receptor member 15 pseudogene Neighboring gene taste 2 receptor member 20 Neighboring gene taste 2 receptor member 19

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    taste receptor type 2 member 50
    Names
    taste receptor type 2 member 51
    taste receptor, type 2, member 50

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176890.2NP_795371.2  taste receptor type 2 member 50

      See identical proteins and their annotated locations for NP_795371.2

      Status: VALIDATED

      Source sequence(s)
      BC112100
      Consensus CDS
      CCDS8638.1
      UniProtKB/Swiss-Prot
      P59544, P59545, Q2M255, Q645Y0
      UniProtKB/TrEMBL
      Q50KE3, Q50KE4
      Related
      ENSP00000424040.1, ENST00000506868.1
      Conserved Domains (1) summary
      cd15027
      Location:3294
      7tm_TAS2R43-like; mammalian taste receptor 2, subtype 43, and related proteins, member of the seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      10985913..10986912 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003571050.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      184619..185618 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187658.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      184606..185605 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      10858932..10859931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)