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    CRAMP1 cramped chromatin regulator homolog 1 [ Homo sapiens (human) ]

    Gene ID: 57585, updated on 10-Dec-2024

    Summary

    Official Symbol
    CRAMP1provided by HGNC
    Official Full Name
    cramped chromatin regulator homolog 1provided by HGNC
    Primary source
    HGNC:HGNC:14122
    See related
    Ensembl:ENSG00000007545 AllianceGenome:HGNC:14122
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HN1L; TCE4; CRAMP1L
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in pattern specification process. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 13.3), skin (RPKM 5.0) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CRAMP1 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (1612360..1677908)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (1628207..1693756)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1662361..1727909)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 140 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1582993-1583696 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1583697-1584400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1592422-1593124 Neighboring gene transmembrane protein 204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1605115-1605614 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:1609654-1609839 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1611806-1612415 Neighboring gene uncharacterized LOC105371046 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10227 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:1662256-1662756 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:1662757-1663257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10230 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:1696049-1696268 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:1701290-1701464 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1728137-1728772 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1739823-1740519 Neighboring gene Sharpr-MPRA regulatory region 11614 Neighboring gene Sharpr-MPRA regulatory region 3989 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1755527-1756391 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6998 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6999 Neighboring gene Jupiter microtubule associated homolog 2 Neighboring gene MAPK8IP3 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10231 Neighboring gene mitogen-activated protein kinase 8 interacting protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: JPT2

    Clone Names

    • MGC176736

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in pattern specification process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein cramped-like
    Names
    Crm, cramped-like
    T-complex expressed gene 4
    hematological and neurological expressed 1-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020825.4NP_065876.3  protein cramped-like

      See identical proteins and their annotated locations for NP_065876.3

      Status: VALIDATED

      Source sequence(s)
      AL031009, AL031708, Z97652
      Consensus CDS
      CCDS10440.2
      UniProtKB/Swiss-Prot
      A8MZL1, B1AJY1, Q8NDN1, Q96RY5, Q9P2C1
      UniProtKB/TrEMBL
      A8MQ73, B2RNX8
      Related
      ENSP00000380559.2, ENST00000397412.8

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      1612360..1677908
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      1628207..1693756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)