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    POLY polyprotein;protein F [ Hepatitis C virus genotype 5 ]

    Gene ID: 11027170, updated on 30-Oct-2023

    Summary

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    Gene symbol
    POLY
    Gene description
    polyprotein;protein F
    Locus tag
    HCV5_gp1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Hepatitis C virus genotype 5 (strain: EUH1480, subtype: 5a, nat-host: Homo sapiens)
    Lineage
    Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes; Amarillovirales; Flaviviridae; Hepacivirus
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    Genomic context

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    Sequence:
    NC_009826.1 (280..9324)

    NC_009826.1Genomic Context describing neighboring genes

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009826.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutational analysis reveals a novel role for hepatitis C virus NS5A domain I in cyclophilin-dependent genome replication. Chen S, et al. J Gen Virol, 2023 Sep. PMID 37672027, Free PMC Article
    2. Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant. Mathiesen CK, et al. J Virol, 2015 Aug. PMID 25995244, Free PMC Article
    3. The complete coding sequence of hepatitis C virus genotype 5a, the predominant genotype in South Africa. Chamberlain RW, et al. Biochem Biophys Res Commun, 1997 Jul 9. PMID 9223423

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutational analysis reveals a novel role for hepatitis C virus NS5A domain I in cyclophilin-dependent genome replication.
      Title: Mutational analysis reveals a novel role for hepatitis C virus NS5A domain I in cyclophilin-dependent genome replication.
    2. Core-NS5B recombination enhanced virus assembly and cell-to-cell transmission.
      Title: Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant.
    Submit: New GeneRIF Correction

    General protein information

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    Preferred Names
    polyprotein;protein F
    Names
    core protein
    E1 protein
    E2 protein
    p7 protein
    NS2 protein
    NS3 protease/helicase
    NS4A protein
    NS4B protein
    NS5A protein
    NS5B RNA-dependent RNA polymerase
    YP_009272646.1
    • -2/+1 frameshift protein F; position predicted based on homology to protein F/predicted ribosomal slippage site in HCV1 RefSeq NC_004102.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_009826.1 Reference assembly

      Range
      280..9324
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_001469633.1 polyprotein [Hepatitis C virus genotype 5]

      See identical proteins and their annotated locations for YP_001469633.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O39928
      UniProtKB/TrEMBL
      A0A068JFK5
      Conserved Domains (15) summary
      pfam01001
      Location:1729 → 1922
      HCV_NS4b; Hepatitis C virus non-structural protein NS4b
      pfam01539
      Location:195 → 382
      HCV_env; Hepatitis C virus envelope glycoprotein E1
      pfam01560
      Location:386 → 730
      HCV_NS1; Hepatitis C virus non-structural protein E2/NS1
      pfam01543
      Location:2 → 115
      HCV_capsid; Hepatitis C virus capsid protein
      pfam08301
      Location:2069 → 2169
      HCV_NS5a_1b; Hepatitis C virus non-structural 5a domain 1b
      pfam01542
      Location:116 → 190
      HCV_core; Hepatitis C virus core protein
      pfam12941
      Location:2180 → 2423
      HCV_NS5a_C; HCV NS5a protein C-terminal region
      cl38915
      Location:1363 → 1484
      DEAD-like_helicase_C; C-terminal helicase domain of the DEAD-like helicases
      pfam00998
      Location:2426 → 2937
      RdRP_3; Viral RNA dependent RNA polymerase
      pfam01006
      Location:1659 → 1712
      HCV_NS4a; Hepatitis C virus non-structural protein NS4a
      pfam01506
      Location:1975 → 1997
      HCV_NS5a; Hepatitis C virus non-structural 5a protein membrane anchor
      pfam01538
      Location:812 → 1006
      HCV_NS2; Hepatitis C virus non-structural protein NS2
      pfam02907
      Location:1057 → 1205
      Peptidase_S29; Hepatitis C virus NS3 protease
      pfam08300
      Location:2007 → 2068
      HCV_NS5a_1a; Hepatitis C virus non-structural 5a zinc finger domain
      cl28899
      Location:1224 → 1367
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    2. YP_009272647.1 core protein

    3. YP_009272648.1 E1 protein

    4. YP_009272649.1 E2 protein

      Conserved Domains (1) summary
      pfam01560
      Location:3 → 347
      HCV_NS1; Hepatitis C virus non-structural protein E2/NS1

    5. YP_009272650.1 p7 protein

    6. YP_009272651.1 NS2 protein

    7. YP_009272652.1 NS3 protease/helicase

    8. YP_009272653.1 NS4A protein

    9. YP_009272654.1 NS4B protein

    10. YP_009272655.1 NS5A protein

    11. YP_009272656.1 NS5B RNA-dependent RNA polymerase

    12. YP_009272646.1 protein F [Hepatitis C virus genotype 5]

      Status: PROVISIONAL

    Protein Accession Links
    GenPept Link UniProtKB Link
    CAA73640.1

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