Sarm1 sterile alpha and TIR motif containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sarm1provided by RGD
Official Full Name: sterile alpha and TIR motif containing 1provided by RGD
Primary source: RGD:1310078
See related: EnsemblRapid:ENSRNOG00000010244 AllianceGenome:RGD:1310078
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable NAD+ nucleosidase activity; NAD+ nucleotidase, cyclic ADP-ribose generating; and identical protein binding activity. Involved in modification of postsynaptic structure. Is active in glutamatergic synapse. Is extrinsic component of synaptic membrane. Orthologous to human SARM1 (sterile alpha and TIR motif containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 38.3), Adrenal (RPKM 9.9) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q25

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (63867503..63890872, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (63369456..63393016, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (65742343..65766050, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Synergistic Protection of Retinal Ganglion Cells (RGCs) by SARM1 Inactivation with CNTF in a Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy.
Title: Synergistic Protection of Retinal Ganglion Cells (RGCs) by SARM1 Inactivation with CNTF in a Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy.
A SARM1-mitochondrial feedback loop drives neuropathogenesis in a Charcot-Marie-Tooth disease type 2A rat model.
Title: A SARM1-mitochondrial feedback loop drives neuropathogenesis in a Charcot-Marie-Tooth disease type 2A rat model.
Phosphorylation at S548 as a Functional Switch of Sterile Alpha and TIR Motif-Containing 1 in Cerebral Ischemia/Reperfusion Injury in Rats.
Title: Phosphorylation at S548 as a Functional Switch of Sterile Alpha and TIR Motif-Containing 1 in Cerebral Ischemia/Reperfusion Injury in Rats.
Cisplatin induced neurotoxicity is mediated by Sarm1 and calpain activation.
Title: Cisplatin induced neurotoxicity is mediated by Sarm1 and calpain activation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137897 (e-PCR)
- UniSTS:219984

d10rat68 (e-PCR)
- UniSTS:120725

D11Seg31 (e-PCR), detects polymorphism
- UniSTS:141806

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD+ nucleosidase activity	IEA Inferred from Electronic Annotation more info
enables NAD+ nucleosidase activity	ISO Inferred from Sequence Orthology more info
enables NAD+ nucleotidase, cyclic ADP-ribose generating	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NAD catabolic process	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in modification of postsynaptic structure	IDA Inferred from Direct Assay more info	PubMed
involved_in modification of postsynaptic structure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of MyD88-independent toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in nervous system process	ISO Inferred from Sequence Orthology more info
involved_in protein localization to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse pruning	ISO Inferred from Sequence Orthology more info
involved_in response to axon injury	IEA Inferred from Electronic Annotation more info
involved_in response to axon injury	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to glucose	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
is_active_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in extrinsic component of synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NAD(+) hydrolase SARM1

Names: NADP(+) hydrolase SARM1; NADase SARM1; sterile alpha and TIR motif-containing protein 1

NP_001099287.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105817.1 → NP_001099287.1 NAD(+) hydrolase SARM1

See identical proteins and their annotated locations for NP_001099287.1

Status: PROVISIONAL

Source sequence(s)

CH473948

UniProtKB/Swiss-Prot

D3ZUM2

UniProtKB/TrEMBL

A0A8I5Y295

Related

ENSRNOP00000013639.5, ENSRNOT00000013639.7

Conserved Domains (3) summary

cd09501
Location:409 → 477

SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1

cd09502
Location:479 → 547

SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2

smart00255
Location:561 → 702

TIR; Toll - interleukin 1 - resistance