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    Slc35c1 solute carrier family 35 member C1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311204, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc35c1provided by RGD
    Official Full Name
    solute carrier family 35 member C1provided by RGD
    Primary source
    RGD:1309463
    See related
    EnsemblRapid:ENSRNOG00000007732 AllianceGenome:RGD:1309463
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GDP-fucose transmembrane transporter activity and antiporter activity. Predicted to be involved in GDP-fucose import into Golgi lumen and protein O-linked fucosylation. Predicted to act upstream of or within lipid glycosylation and negative regulation of Notch signaling pathway. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIc. Orthologous to human SLC35C1 (solute carrier family 35 member C1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 45.2), Kidney (RPKM 43.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc35c1 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (98877413..98887411, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (78421925..78429603, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (81361080..81369010, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 8 interacting protein 1 Neighboring gene Frey regulator of sperm-oocyte fusion 1 Neighboring gene cryptochrome circadian regulator 2 Neighboring gene uncharacterized LOC102546693 Neighboring gene uncharacterized LOC120101599 Neighboring gene uncharacterized LOC108350417

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency. Lübke T, et al. Nat Genet, 2001 May. PMID 11326280
    2. Slc35c2 promotes Notch1 fucosylation and is required for optimal Notch signaling in mammalian cells. Lu L, et al. J Biol Chem, 2010 Nov 12. PMID 20837470, Free PMC Article
    3. Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3. Rabionet M, et al. J Biol Chem, 2008 May 9. PMID 18308723, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GDP-fucose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP-fucose transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' GDP-L-fucose biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GDP-L-fucose salvage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GDP-fucose import into Golgi lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GDP-fucose import into Golgi lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within lipid glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GDP-fucose transporter 1
    Names
    solute carrier family 35 (GDP-fucose transporter), member C1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107748.1 → NP_001101218.1  GDP-fucose transporter 1

      See identical proteins and their annotated locations for NP_001101218.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473949
      UniProtKB/TrEMBL
      A6HNH7, D3ZWW0
      Related
      ENSRNOP00000059968.1, ENSRNOT00000067509.3
      Conserved Domains (1) summary
      pfam03151
      Location:38 → 302
      TPT; Triose-phosphate Transporter family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      98877413..98887411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234568.4 → XP_006234630.1  GDP-fucose transporter 1 isoform X1

      See identical proteins and their annotated locations for XP_006234630.1

      UniProtKB/TrEMBL
      A6HNH8
      Conserved Domains (1) summary
      cl26744
      Location:25 → 289
      TPT; Triose-phosphate Transporter family

    2. XM_008762026.3 → XP_008760248.1  GDP-fucose transporter 1 isoform X1

      See identical proteins and their annotated locations for XP_008760248.1

      UniProtKB/TrEMBL
      A6HNH8
      Conserved Domains (1) summary
      cl26744
      Location:25 → 289
      TPT; Triose-phosphate Transporter family

    3. XM_039104908.2 → XP_038960836.1  GDP-fucose transporter 1 isoform X1

      UniProtKB/TrEMBL
      A6HNH8
      Conserved Domains (1) summary
      cl26744
      Location:25 → 289
      TPT; Triose-phosphate Transporter family
    Nucleotide Protein Strain
    Heading Accession and Version

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