Actg2 actin, gamma 2, smooth muscle, enteric [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Actg2provided by MGI
Official Full Name: actin, gamma 2, smooth muscle, entericprovided by MGI
Primary source: MGI:MGI:104589
See related: Ensembl:ENSMUSG00000059430 AllianceGenome:MGI:104589
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Act4; SMGA; ACTA3; Act-4
Summary: Predicted to enable ATP binding activity and hydrolase activity. Predicted to be involved in mesenchyme migration and positive regulation of gene expression. Located in cell periphery. Is expressed in alimentary system; arch of aorta; and genitourinary system. Used to study megacystis-microcolon-intestinal hypoperistalsis syndrome. Human ortholog(s) of this gene implicated in megacystis-microcolon-intestinal hypoperistalsis syndrome. Orthologous to human ACTG2 (actin gamma 2, smooth muscle). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in bladder adult (RPKM 2840.7), colon adult (RPKM 638.4) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 C3; 6 35.94 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (83489891..83513233, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (83512909..83536251, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Heterozygous Actg2[R257C] mice mimic the phenotype of megacystis microcolon intestinal hypoperistalsis syndrome.
Title: Heterozygous Actg2(R257C) mice mimic the phenotype of megacystis microcolon intestinal hypoperistalsis syndrome.
ACTG2 boosts the metastatic potential of hepatocellular carcinoma in a Notch1-dependent manner.
Title: Identification of ACTG2 functions as a promoter gene in hepatocellular carcinoma cells migration and tumor metastasis.
MYOCD can discriminate among several juxtaposed CArG elements, presumably through its novel partnership with NKX3.1, to optimally transactivate the human ACTG2 promoter
Title: Myocardin-dependent activation of the CArG box-rich smooth muscle gamma-actin gene: preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6UmiJ1 (e-PCR), detects polymorphism
- UniSTS:260405

PMC20377P1 (e-PCR)
- UniSTS:271939

PMC23952P1 (e-PCR)
- UniSTS:272216

PMC20960P1 (e-PCR)
- UniSTS:272003

PMC193670P1 (e-PCR)
- UniSTS:271752

PMC22515P2 (e-PCR)
- UniSTS:272118

PMC117352P1 (e-PCR)
- UniSTS:270329

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mesenchyme migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in filopodium	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in myosin filament	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: actin, gamma-enteric smooth muscle

Names: alpha-actin-3; gamma-2-actin; smooth muscle gamma-actin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.